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Author Details

Martin W Brechbiel
National Institutes of Health
1985
344
72
PMIDPaper TitleJournal TitlePublished Year
35981897Cure of Micrometastatic B-Cell Lymphoma in a SCID Mouse Model Using <sup>213</sup>Bi-Anti-CD20 Monoclonal Antibody.J Nucl Med2023
36809052Immunotherapy for Cancer: Something Old, Something New.Cancer Biother Radiopharm2023
33277392Agent Optimization: Absorption, Distribution, Metabolism, Excretion, Dose, and Decay.J Nucl Med2021
31253744Preclinical Evaluation of <sup>203/212</sup>Pb-Labeled Low-Molecular-Weight Compounds for Targeted Radiopharmaceutical Therapy of Prostate Cancer.J Nucl Med2020
32944719Reply to the 'Comment on "Investigation of Zr(iv) and <sup>89</sup>Zr(iv) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging"' by A. Bianchi and M. Savastano, Chem. Commun., 2020, 56, D0CC01189D.Chem Commun (Camb)2020
32503377Targeted α-Therapy.Cancer Biother Radiopharm2020
32275165<sup>90</sup>Y-Daclizumab (Anti-CD25), High-Dose Carmustine, Etoposide, Cytarabine, and Melphalan Chemotherapy and Autologous Hematopoietic Stem Cell Transplant Yielded Sustained Complete Remissions in 4 Patients with Recurrent Hodgkin's Lymphoma.Cancer Biother Radiopharm2020
31211593"Controls? Controls?? We Don't Need No Stinkin' Controls!"Cancer Biother Radiopharm2019
29466033A New Era of Cancer Biotherapy and Radiopharmaceuticals.Cancer Biother Radiopharm2018
29916748Exploration of a F(ab')<sub>2</sub> Fragment as the Targeting Agent of α-Radiation Therapy: A Comparison of the Therapeutic Benefit of Intraperitoneal and Intravenous Administered Radioimmunotherapy.Cancer Biother Radiopharm2018
29916746On Reviewing.Cancer Biother Radiopharm2018
30199276Two Days at the Hunter College Symposium on Radiometals in New York City.Cancer Biother Radiopharm2018
29641254More Thoughts on Standards and Reproducibility.Cancer Biother Radiopharm2018
28577439Targeted α-Particle Radiation Therapy of HER1-Positive Disseminated Intraperitoneal Disease: An Investigation of the Human Anti-EGFR Monoclonal Antibody, Panitumumab.Transl Oncol2017
28338136Investigation of the complexation of <sup>nat</sup>Zr(iv) and <sup>89</sup>Zr(iv) by hydroxypyridinones for the development of chelators for PET imaging applications.Dalton Trans2017
28964629Bifunctional aryliodonium salts for highly efficient radioiodination and astatination of antibodies.Bioorg Med Chem2017
28675216Comparative studies on the therapeutic benefit of targeted α-particle radiation therapy for the treatment of disseminated intraperitoneal disease.Dalton Trans2017
27030023Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor.MAbs2016
27305065Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts.Chemistry2016
27230930(2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy.J Nucl Med2016
27196891Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from (177)Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts.Int J Mol Sci2016
27192116The IDO1 selective inhibitor epacadostat enhances dendritic cell immunogenicity and lytic ability of tumor antigen-specific T cells.Oncotarget2016
27467592Cell Killing Mechanisms and Impact on Gene Expression by Gemcitabine and 212Pb-Trastuzumab Treatment in a Disseminated i.p. Tumor Model.PLoS One2016
26983636Engineering anti-Lewis-Y hu3S193 antibodies with improved therapeutic ratio for radioimmunotherapy of epithelial cancers.EJNMMI Res2016
25587678Evaluation of cetuximab as a candidate for targeted α-particle radiation therapy of HER1-positive disseminated intraperitoneal disease.MAbs2015
2643886690Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma.Proc Natl Acad Sci U S A2015
26858987Application of <sup>212</sup>Pb for Targeted α-particle Therapy (TAT): Pre-clinical and Mechanistic Understanding through to Clinical Translation.AIMS Med Sci2015
26124477Phase I Imaging and Pharmacodynamic Trial of CS-1008 in Patients With Metastatic Colorectal Cancer.J Clin Oncol2015
26230702Bench to Bedside: Stability Studies of GMP Produced Trastuzumab-TCMC in Support of a Clinical Trial.Pharmaceuticals (Basel)2015
26213947Toxicological Studies of 212Pb Intravenously or Intraperitoneally Injected into Mice for a Phase 1 Trial.Pharmaceuticals (Basel)2015
25870133Synthesis and characterization of gadolinium-Peptidomimetic complex as an αvβ3 integrin targeted MR contrast agent.Bioorg Med Chem Lett2015
25945808First-In-Human Study Demonstrating Tumor-Angiogenesis by PET/CT Imaging with (68)Ga-NODAGA-THERANOST, a High-Affinity Peptidomimetic for αvβ3 Integrin Receptor Targeting.Cancer Biother Radiopharm2015
25722448Preclinical evaluation of 86Y-labeled inhibitors of prostate-specific membrane antigen for dosimetry estimates.J Nucl Med2015
24761300Wide-field in vivo background free imaging by selective magnetic modulation of nanodiamond fluorescence.Biomed Opt Express2014
25243604In vitro and in vivo analysis of indocyanine green-labeled panitumumab for optical imaging-a cautionary tale.Bioconjug Chem2014
25268703Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel.PLoS One2014
24740517Rational design, synthesis, and evaluation of tetrahydroxamic acid chelators for stable complexation of zirconium(IV).Chemistry2014
23075373Production of [(211)At]-astatinated radiopharmaceuticals and applications in targeted α-particle therapy.Cancer Biother Radiopharm2013
24403230Gene expression profiling upon (212) Pb-TCMC-trastuzumab treatment in the LS-174T i.p. xenograft model.Cancer Med2013
24045184Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008.Clin Cancer Res2013
23632482212Pb-radioimmunotherapy potentiates paclitaxel-induced cell killing efficacy by perturbing the mitotic spindle checkpoint.Br J Cancer2013
23602604Methodology for labeling proteins and peptides with lead-212 (212Pb).Nucl Med Biol2013
23657262Surface-engineered nanomaterials as X-ray absorbing adjuvant agents for Auger-mediated chemo-radiation.Nanoscale2013
23758610Evaluation of platinum chemotherapy in combination with HER2-targeted α-particle radiation.Cancer Biother Radiopharm2013
23581827Silica encapsulation of fluorescent nanodiamonds for colloidal stability and facile surface functionalization.J Am Chem Soc2013
23541026Preclinical evaluation of NETA-based bifunctional ligand for radioimmunotherapy applications using 212Bi and 213Bi: radiolabeling, serum stability, and biodistribution and tumor uptake studies.Nucl Med Biol2013
23230321Molecular pathways: targeted α-particle radiation therapy.Clin Cancer Res2013
23200172Sensitization of tumor to ²¹²Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51.Int J Radiat Oncol Biol Phys2013
23250287Investigation of Zr(IV) and 89Zr(IV) complexation with hydroxamates: progress towards designing a better chelator than desferrioxamine B for immuno-PET imaging.Chem Commun (Camb)2013
23329660Orthotopic pleural mesothelioma in mice: SPECT/CT and MR imaging with HER1- and HER2-targeted radiolabeled antibodies.Radiology2013
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Collaborators

Center for Cancer Research
Co-authored papers 46
National Cancer Institute, National Institutes of Health
Co-authored papers 26
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 22
Center for Interventional Oncology, National Institutes of Health
Co-authored papers 16
National Cancer Institute, National Institutes of Health
Co-authored papers 10
Ludwig Institute for Cancer Research
Co-authored papers 8
National Institutes of Health
Co-authored papers 4
Olivia Newton-John Cancer Research Institute
Co-authored papers 4
National Cancer Institute
Co-authored papers 3
Telethon Kids Institute
Co-authored papers 3
Monash University
Co-authored papers 3
Johns Hopkins Bloomberg School of Public Health
Co-authored papers 2
Co-authored papers 2
The University of Kansas Medical Center
Co-authored papers 2
Co-authored papers 2
National Cancer Institute
Co-authored papers 2
National Cancer Institute, National Institutes of Health
Co-authored papers 2
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 2
College of Science, RMIT University
Co-authored papers 2
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Health Services and Systems Research, Duke-NUS Medical School
Co-authored papers 2
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Co-authored papers 1
Allegheny General Hospital
Co-authored papers 1
Biomedicine Discovery Institute, Monash University
Co-authored papers 1
Boston Children's Hospital and Harvard Medical School
Co-authored papers 1
Columbia University Medical Center Kreitchman PET Center
Co-authored papers 1
First Hospital of Shanxi Medical University, Shanxi Medical University
Co-authored papers 1
University of Fukui.
Co-authored papers 1
National Cancer Institute, National Institutes of Health
Co-authored papers 1