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Author Details

Raj Chari
The National Institutes of Health
2006
83
34
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36717694Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness.Nat Genet2023
37662356Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR.bioRxiv2023
37706203Combined inhibition of topoisomerase I and poly(ADP-ribose) polymerase: A synergistic therapeutic strategy for glioblastoma with phosphatase and tensin homolog deficiency.Neurooncol Adv2023
37985687AGO2 silences mobile transposons in the nucleus of quiescent cells.Nat Struct Mol Biol2023
37645932EWSR1's visual modalities are defined by its association with nucleic acids and RNA polymerase II.bioRxiv2023
37354974An engineered cell line with a hRpn1-attached handle to isolate proteasomes.J Biol Chem2023
37059104Phenotypic plasticity and reduced tissue retention of exhausted tumor-infiltrating T cells following neoadjuvant immunotherapy in head and neck cancer.Cancer Cell2023
37129573The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability.J Cell Sci2023
37463106SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck.Cell Rep2023
36924503Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B.Cell Rep2023
36787739Targeted long-read sequencing of the Ewing sarcoma 6p25.1 susceptibility locus identifies germline-somatic interactions with EWSR1-FLI1 binding.Am J Hum Genet2023
35274990An Evolutionarily Conserved AU-Rich Element in the 3' Untranslated Region of a Transcript Misannotated as a Long Noncoding RNA Regulates RNA Stability.Mol Cell Biol2022
35586249<i>Mycobacterium tuberculosis</i> Induces <i>Irg1</i> in Murine Macrophages by a Pathway Involving Both TLR-2 and STING/IFNAR Signaling and Requiring Bacterial Phagocytosis.Front Cell Infect Microbiol2022
35404385CPAP insufficiency leads to incomplete centrioles that duplicate but fragment.J Cell Biol2022
36423637Massively parallel reporter assays and variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity.Am J Hum Genet2022
36454826Active DNA demethylation promotes cell fate specification and the DNA damage response.Science2022
36342127Context-Dependent Function of Long Noncoding RNA <i>PURPL</i> in Transcriptome Regulation during p53 Activation.Mol Cell Biol2022
35285626Protonation-Dependent Sequencing of 5-Formylcytidine in RNA.Biochemistry2022
33051688dbGuide: a database of functionally validated guide RNAs for genome editing in human and mouse cells.Nucleic Acids Res2021
33837043Small-Molecule Natural Product Physachenolide C Potentiates Immunotherapy Efficacy by Targeting BET Proteins.Cancer Res2021
33857404The dystonia gene THAP1 controls DNA double-strand break repair choice.Mol Cell2021
34916494Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.Nat Commun2021
34879065A structurally conserved site in AUP1 binds the E2 enzyme UBE2G2 and is essential for ER-associated degradation.PLoS Biol2021
34960191Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells.Vaccines (Basel)2021
34343493A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.Am J Hum Genet2021
34193462Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response.Cancer Immunol Res2021
32157086Structure of E3 ligase E6AP with a proteasome-binding site provided by substrate receptor hRpn10.Nat Commun2020
32004714Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression.J Thorac Oncol2020
33112233A small protein encoded by a putative lncRNA regulates apoptosis and tumorigenicity in human colorectal cancer cells.Elife2020
33101674Metabolic plasticity of IDH1<i>-mutant</i> glioma cell lines is responsible for low sensitivity to glutaminase inhibition.Cancer Metab2020
32631902Impact of Losing hRpn13 Pru or UCHL5 on Proteasome Clearance of Ubiquitinated Proteins and RA190 Cytotoxicity.Mol Cell Biol2020
32483191Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.Nat Commun2020
31780666Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma.Nat Commun2019
28852223Beyond editing to writing large genomes.Nat Rev Genet2017
28146356sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity.ACS Synth Biol2017
27214048Comparison of Cas9 activators in multiple species.Nat Methods2016
26167643Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach.Nat Methods2015
26481611Neutralizing antibodies against West Nile virus identified directly from human B cells by single-cell analysis and next generation sequencing.Integr Biol (Camb)2015
26344044Cas9 gRNA engineering for genome editing, activation and repression.Nat Methods2015
26714111A general strategy to construct small molecule biosensors in eukaryotes.Elife2015
24096489EYA4 is inactivated biallelically at a high frequency in sporadic lung cancer and is associated with familial lung cancer risk.Oncogene2014
25425480Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.Nat Commun2014
24639495High-resolution antibody dynamics of vaccine-induced immune responses.Proc Natl Acad Sci U S A2014
24298892DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways.Am J Respir Cell Mol Biol2014
23785438Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor.PLoS One2013
24170126YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway.Cancer Res2013
22412972Lung adenocarcinoma of never smokers and smokers harbor differential regions of genetic alteration and exhibit different levels of genomic instability.PLoS One2012
22740649Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers.Nucleic Acids Res2012
22629454Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.PLoS One2012
22301133Translating cancer 'omics' to improved outcomes.Genome Res2012
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Collaborators

Wan L Lam
British Columbia Cancer Research Institute
Co-authored papers 41
George M Church
Harvard Medical School
Co-authored papers 10
Ming-Sound Tsao
University Health Network, University of Toronto
Co-authored papers 8
Larissa A Pikor
Ottawa Hospital Research Institute
Co-authored papers 6
John D Minna
University of Texas Southwestern Medical Center at Dallas
Co-authored papers 5
Kylie J Walters
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 5
Stephen J Chanock
National Cancer Institute, National Institutes of Health
Co-authored papers 4
Mirit I Aladjem
National Cancer Institute, Center for Cancer Research
Co-authored papers 3
Alejandro Chavez
Co-authored papers 3
Myriam Gorospe
National Institute on Aging (NIA), National Institutes of Health (NIH)
Co-authored papers 3
Wei Zhang
Montefiore Medical Center
Co-authored papers 2
Mitchell J Machiela
National Cancer Institute
Co-authored papers 2
Chad A Malloff
BC Cancer Research Centre
Co-authored papers 2
Xavier Rios
Texas Children's Hospital, Baylor College of Medicine
Co-authored papers 2
Maria Teresa Landi
National Cancer Institute
Co-authored papers 2
Yves Pommier
Center for Cancer Research, National Cancer Institute
Co-authored papers 2
Adrian W Briggs
Harvard University
Co-authored papers 2
Luhan Yang
College of Resources and Environment, Southwest University
Co-authored papers 2
Marco A Marra
University of British Columbia
Co-authored papers 2
Natasha J Caplen
Co-authored papers 2
Prashant Mali (CM4AI)
University of California San Diego
Co-authored papers 2
Chang-Qi Zhu
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Martin Hirst
University of British Columbia
Co-authored papers 1
Frank B Furnari
University of California San Diego
Co-authored papers 1
Mohammad R Ebrahimkhani
Co-authored papers 1
Christine E Seidman
Brigham and Women's Hospital (Y.K.
Co-authored papers 1
Didier Surdez
Balgrist University Hospital, University of Zurich (UZH)
Co-authored papers 1
William R Diver
Co-authored papers 1
Erez Lieberman Aiden
Co-authored papers 1
Margaret A Tucker
National Cancer Institute
Co-authored papers 1
Release 1.2