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Author Details

Martin Kampmann
Institute for Neurodegenerative Diseases, University of California san francisco
2003
91
39
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36790927Genomic profiling of HIV-1 integration in microglia cells links viral integration to the topologically associated domains.Cell Rep2023
37745431Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.bioRxiv2023
37550454DELE1 oligomerization promotes integrated stress response activation.Nat Struct Mol Biol2023
37693477Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes.bioRxiv2023
37494933Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.Dev Cell2023
36945568A molecular glue approach to control the half-life of CRISPR-based technologies.bioRxiv2023
37398301Scalable, cell type-selective, AAV-based <i>in vivo</i> CRISPR screening in the mouse brain.bioRxiv2023
37398204CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis.bioRxiv2023
37164963Viral subversion of selective autophagy is critical for biogenesis of virus replication organelles.Nat Commun2023
37163077CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions.bioRxiv2023
37027294Neurons require glucose uptake and glycolysis in vivo.Cell Rep2023
36638793An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes.Cell2023
36798226MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state.medRxiv2023
35108506Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer.Cell Chem Biol2022
35522480Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model.ACS Chem Neurosci2022
36401300Towards elucidating disease-relevant states of neurons and glia by CRISPR-based functional genomics.Genome Med2022
36576240Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.Elife2022
36459969A reference human induced pluripotent stem cell line for large-scale collaborative studies.Cell Stem Cell2022
36303069CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.Nat Neurosci2022
35953545A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.Nat Neurosci2022
36323693Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin.Nat Commun2022
36116133Reduced endosomal microautophagy activity in aging associates with enhanced exocyst-mediated protein secretion.Aging Cell2022
35188214Conversations with LGBT+ scientists about visibility, leadership and climbing the career ladder.J Cell Sci2022
35063133NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems.Mol Cell2022
35027731BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.Nat Cell Biol2022
35171471CRISPR-Based Screening for Stress Response Factors in Mammalian Cells.Methods Mol Biol2022
33432193Molecular characterization of selectively vulnerable neurons in Alzheimer's disease.Nat Neurosci2021
33547632Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability.Cell Stress Chaperones2021
33677647Patterns of neuronal Rhes as a novel hallmark of tauopathies.Acta Neuropathol2021
33838111Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.Cell2021
33501440BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.bioRxiv2021
34034859Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.Elife2021
34031600Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis.Nat Neurosci2021
32132707Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.Nature2020
32076268Gene expression and cell identity controlled by anaphase-promoting complex.Nature2020
33052901A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling.PLoS Genet2020
32859923Defining the ATPome reveals cross-optimization of metabolic pathways.Nat Commun2020
32619469Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.Mol Cell2020
32589729CRISPR-based screens uncover determinants of immunotherapy response in multiple myeloma.Blood Adv2020
32786289Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.ACS Chem Biol2020
32641861CRISPR-based functional genomics for neurological disease.Nat Rev Neurol2020
32152544Deep mutational scanning reveals the structural basis for α-synuclein activity.Nat Chem Biol2020
32296178LRP1 is a master regulator of tau uptake and spread.Nature2020
30846318Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.Mol Cell2019
31578281Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.J Biol Chem2019
31422865CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.Neuron2019
31149896Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.Elife2019
30733284Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia.Proc Natl Acad Sci U S A2019
30765536Heterochromatin anomalies and double-stranded RNA accumulation underlie <i>C9orf72</i> poly(PR) toxicity.Science2019
29334369Dual gene activation and knockout screen reveals directional dependencies in genetic networks.Nat Biotechnol2018
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Collaborators

Jonathan S Weissman
Whitehead Institute for Biomedical Research
Co-authored papers 25
Michael C Bassik
Stanford University Medical Center
Co-authored papers 14
Max A Horlbeck
Broad Institute of MIT and Harvard
Co-authored papers 10
Luke A Gilbert
Arc Institute
Co-authored papers 10
Avi J Samelson
Institute for Neurodegenerative Diseases, University of California san francisco
Co-authored papers 6
Michael E Ward
National Institute of Neurological, National Institutes of Health (NIH)
Co-authored papers 6
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 4
Mike A Nalls
Center for Alzheimer's and Related Dementias, National Institutes of Health
Co-authored papers 4
Peter Walter
University of California san francisco
Co-authored papers 4
Stephanie K See
University of California san francisco
Co-authored papers 4
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 4
Claire E Atkinson
The University of British Columbia
Co-authored papers 3
G??nter Blobel
Howard Hughes Medical Institute, The Rockefeller University
Co-authored papers 3
Sue-Ann Mok
University of Alberta
Co-authored papers 3
Michael T McManus
Co-authored papers 3
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 3
Jacqueline E Villalta
University of California san francisco
Co-authored papers 3
James A Wells
Department of Pharmaceutical Chemistry, University of California San Francisco
Co-authored papers 3
Bruce R Conklin
Gladstone Institutes
Co-authored papers 3
Andrew B Singleton
National Institute on Aging
Co-authored papers 2
Jennifer Oki
Synthego Corporation
Co-authored papers 2
Jared Carlson-Stevermer
Synthego Corporation
Co-authored papers 2
Irene Lui
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
William W Seeley
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 2
Jordan C Tsai
University of California san francisco
Co-authored papers 2
Jack Taunton
University of California san francisco
Co-authored papers 2
Travis J Maures
University of Michigan Medical School ann arbor
Co-authored papers 2
Erik Verschueren
University of California San Francisco
Co-authored papers 2
Marco Vignuzzi
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
Mark von Zastrow
University of California san francisco
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