Author details

Full Name

Arvin C Dar

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37537299	WNTinib is a multi-kinase inhibitor with specificity against Î²-catenin mutant hepatocellular carcinoma.	Nat Cancer	2023
37919548	Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.		2023
35244677	Understanding and drugging RAS: 40â¿¿years to break the tip of the iceberg.	DMM Disease Models and Mechanisms	2022
35525547	Conformational control and regulation of the pseudokinase KSR via small molecule binding interactions.	Methods in Enzymology	2022
35697804	Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR.	Nat Biotechnol	2022
35726064	Targeting drug-resistant mutations in ALK.	Nature Cancer	2022
36400004	RASopathy mutations open new insights into the mechanism of BRAF activation.	Molecular Cell	2022
33440120	Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADÎ±.	Biochemistry	2021
32679092	Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance.	Cell Chemical Biology	2020
32927473	Structural basis for the action of the drug trametinib at KSR-bound MEK.	Nature	2020
31196969	Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability.	Mol Cell Proteomics	2019
31026276	Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.	PLoS Comput Biol	2019
31213506	Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology.	Mol Cancer Ther	2019
29355849	A whole-animal platform to advance a clinical kinase inhibitor into new disease space.	Nat Chem Biol	2018
28718326	CNS Anticancer Drug Discovery and Development: 2016 conference insights.	CNS Oncol	2017
27556948	Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.	Nature	2016
25986605	Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic.	Elife	2015
26403167	CNS Anticancer Drug Discovery and Development Conference White Paper.	Neuro Oncol	2015
25403145	Hepatitis C virus genetics affects miR-122 requirements and response to miR-122 inhibitors.	Nat Commun	2014
23841803	Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology.	ACS Chem Biol	2013
23863168	A pickup in pseudokinase activity.	Biochemical Society Transactions	2013
22678283	Chemical genetic discovery of targets and anti-targets for cancer polypharmacology.	Nature	2012
21548788	The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.	Annu Rev Biochem	2011
21441910	A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.	Nature	2011
23836541	Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry.	Curr Protoc Chem Biol	2010
18940662	Small molecule recognition of c-Src via the Imatinib-binding conformation.	Chem Biol	2008
18971339	Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.	Proceedings of the National Academy of Sciences of the United States of America	2008
16179258	Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.	Cell	2005
15798194	PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha.	Molecular and Cellular Biology	2005
16179259	Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.	Cell	2005
14561409	Formin leaky cap allows elongation in the presence of tight capping proteins.	Curr Biol	2003
12191475	X-ray crystal structure and functional analysis of vaccinia virus K3L reveals molecular determinants for PKR subversion and substrate recognition.	Molecular Cell	2002
12384601	Slipped-strand DNAs formed by long (CAG)*(CTG) repeats: slipped-out repeats and slip-out junctions.	Nucleic Acids Research	2002