Author details

Full Name

Karen L Mohlke

Affiliation

ORCID

Career Start Year

1993

Papers

250

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
36125445	Mediation analysis of multiple mediators with incomplete omics data.	Genetic Epidemiology	2023
37647564	Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits.	Diabetes	2023
37961277	Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.	bioRxiv	2023
36493769	Genome-wide analysis of copy-number variation in humans with cleft lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as clefting genes.	Am J Hum Genet	2023
36693378	Loci for insulin processing and secretion provide insight into type 2 diabetes risk.	Am J Hum Genet	2023
36798360	Wnt activity reveals context-specific genetic effects on gene regulation in neural progenitors.		2023
37494057	Genetic Variants Associated With Hidradenitis Suppurativa.	JAMA Dermatol	2023
34995504	Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits.	Am J Hum Genet	2022
35589964	ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19.	Int J Obes (Lond)	2022
35393509	Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.	Commun Biol	2022
35513483	Author Correction: Identification of genetic effects underlying type 2 diabetes in South Asian and European populations.	Commun Biol	2022
36099032	3D chromatin structure in chondrocytes identifies putative osteoarthritis risk genes.	Genetics	2022
35697829	Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.	Commun Biol	2022
35746833	Long-range chromosomal interactions increase and mark repressed gene expression during adipogenesis.	Epigenetics	2022
35551307	Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.	Nat Genet	2022
36055244	Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.	Am J Hum Genet	2022
36477530	Genetic diversity fuels gene discovery for tobacco and alcohol use.	Nature	2022
34703007	Integration of DNA sequencing with population pharmacokinetics to improve the prediction of irinotecan exposure in cancer patients.	Br J Cancer	2022
34699533	Chromatin accessibility and gene expression during adipocyte differentiation identify context-dependent effects at cardiometabolic GWAS loci.	PLoS Genet	2021
34108472	Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.	Nat Commun	2021
33727701	Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.	Nat Genet	2021
34038741	Genetic effects on liver chromatin accessibility identify disease regulatory variants.	Am J Hum Genet	2021
33924653	Identification of Novel Candidate Genes and Variants for Hearing Loss and Temporal Bone Anomalies.	Genes	2021
34340684	Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.	Genome Med	2021
33152101	Assessment of familial risk in patients with hidradenitis suppurativa.	British Journal of Dermatology	2021
32709676	Otitis media susceptibility and shifts in the head and neck microbiome due to <i>SPINK5</i> variants.	J Med Genet	2021
34461981	Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.	Genome Med	2021
34706549	Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults.	Circ Genom Precis Med	2021
32888493	Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.	Cell	2020
32127796	Inferring Regulatory Networks From Mixed Observational Data Using Directed Acyclic Graphs.	Front Genet	2020
31883642	Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts.	Am J Hum Genet	2020
31868224	A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes.	Clin Pharmacol Ther	2020
32383070	Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood.	Eur J Epidemiol	2020
32817962	ACE2 expression in adipose tissue is associated with COVID-19 cardio-metabolic risk factors and cell type composition.	medRxiv	2020
32925908	The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.	PLoS Genet	2020
32915782	Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences.	PLoS Genet	2020
32511796	Assessing exposure effects on gene expression.	Genet Epidemiol	2020
33230300	Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.	Nat Genet	2020
32999275	Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.	Nat Commun	2020
32888494	The Polygenic and Monogenic Basis of Blood Traits and Diseases.	Cell	2020
31358974	New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.	Nat Hum Behav	2019
31564431	Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits.	Am J Hum Genet	2019
30445632	Enhancer deletion and allelic effects define a regulatory molecular mechanism at the VLDLR cholesterol GWAS locus.	Human Molecular Genetics	2019
31186305	Open Chromatin Profiling in Adipose Tissue Marks Genomic Regions with Functional Roles in Cardiometabolic Traits.	G3 (Bethesda)	2019
31539074	Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study.	JAMA Netw Open	2019
31538139	Reverse gene-environment interaction approach to identify variants influencing body-mass index in humans.	Nat Metab	2019
31491410	Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.	Am J Hum Genet	2019
31070104	Genetic Determinants of Circulating Glycine Levels and Risk of Coronary Artery Disease.	J Am Heart Assoc	2019
31160809	Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2019