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Author Details

Carsten Skarke
University of Pennsylvania.
1995
61
25
PMIDPaper TitleJournal TitlePublished Year
36824952Diurnal rhythmicity of wearable device-measured wrist temperature predicts future disease incidence in the UK Biobank.Res Sq2023
37808824Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.bioRxiv2023
37620332Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank.Nat Commun2023
37689782Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms.Nat Commun2023
37105582Modulation of the Immune Response to Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination by Nonsteroidal Anti-Inflammatory Drugs.J Pharmacol Exp Ther2023
37205602Prognostic utility of rhythmic components in 24-hour ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity.medRxiv2023
34724846Nitecap: An Exploratory Circadian Analysis Web Application.J Biol Rhythms2022
35332134No increase in inflammation in late-life major depression screened to exclude physical illness.Transl Psychiatry2022
33342316Guidelines for the design and conduct of human clinical trials on ingestion-time differences - chronopharmacology and chronotherapy - of hypertension medications.Chronobiol Int2021
34976917Considerations for the Safe Operation of Schools During the Coronavirus Pandemic.Front Public Health2021
32812805Diet-Epigenome Axis.Circ Genom Precis Med2020
29290411CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.EBioMedicine2018
29215023A Pilot Characterization of the Human Chronobiome.Sci Rep2017
29107287Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.Mol Metab2017
26180051Bioactive products formed in humans from fish oils.J Lipid Res2015
26332979Molecular clocks and the human condition: approaching their characterization in human physiology and disease.Diabetes Obes Metab2015
25450471Selective COX-2 inhibitors suppress prostacyclin.Clin Ther2014
23092618Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.Fitoterapia2013
27121942GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose-Exposure Relationships to Define Clinical Development Strategies.Clin Pharmacol Drug Dev2013
23775505Non-invasive combined surrogates of remifentanil blood concentrations with relevance to analgesia.Naunyn Schmiedebergs Arch Pharmacol2013
22167571Increased bioavailability of 11-keto-β-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: modeling and simulation considerations for evaluating drug exposures.J Clin Pharmacol2012
23150076Myrtucommulone from Myrtus communis: metabolism, permeability, and systemic exposure in rats.Planta Med2012
22278334Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649.Clin Pharmacol Ther2012
20375362Training translators for smart drug discovery.Sci Transl Med2010
19374837On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance.Eur J Pharmacol2009
19648270Identification of human cathepsin G as a functional target of boswellic acids from the anti-inflammatory remedy frankincense.J Immunol2009
18085997Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.Pharmacogenomics2007
17916229Effects of selective COX-2 inhibition on prostanoids and platelet physiology in young healthy volunteers.J Thromb Haemost2007
16515396Rapid identification of three functionally relevant polymorphisms in the OATP1B1 transporter gene using Pyrosequencing.Pharmacogenomics2006
17178263The cyclooxygenase 2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production.Clin Pharmacol Ther2006
16413243Modulation of the central nervous effects of levomethadone by genetic polymorphisms potentially affecting its metabolism, distribution, and drug action.Clin Pharmacol Ther2006
16413240Evidence for morphine-independent central nervous opioid effects after administration of codeine: contribution of other codeine metabolites.Clin Pharmacol Ther2006
15704610Comparison of two screening methods for in-house genotyping in clinical pharmacology units.Int J Clin Pharmacol Ther2005
16153398The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression.Clin Pharmacol Ther2005
16307269Rapid genotyping for relevant CYP1A2 alleles by pyrosequencing.Eur J Clin Pharmacol2005
15830250[Fundamental principles of clinical trials].Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz2005
15982815Is morphine-3-glucuronide of therapeutic relevance?Pain2005
15049432Single-step identification of all length polymorphisms in the UGT1A1 gene promoter.Int J Clin Pharmacol Ther2004
15530129Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives.Clin Pharmacokinet2004
15564947Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans.Anesthesiology2004
14981031Comprehensive mu-opioid-receptor genotyping by pyrosequencing.Clin Chem2004
12545149Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers.Clin Pharmacol Ther2003
12895198Pharmacokinetics of morphine are not altered in subjects with Gilbert's syndrome.Br J Clin Pharmacol2003
14559207Simultaneous screening for three mutations in the ABCB1 gene.Genomics2003
14594747Olfactory function in mild cognitive impairment and Alzheimer's disease: an investigation using psychophysical and electrophysiological techniques.Am J Psychiatry2003
14534517Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine.Clin Pharmacol Ther2003
14583678Effects of ABCB1 (multidrug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers.Pharmacogenetics2003
11773859The polymorphism A118G of the human mu-opioid receptor gene decreases the pupil constrictory effect of morphine-6-glucuronide but not that of morphine.Pharmacogenetics2002
12189362Pharmacokinetic modeling to predict morphine and morphine-6-glucuronide plasma concentrations in healthy young volunteers.Clin Pharmacol Ther2002
12357145Does the A118G polymorphism at the mu-opioid receptor gene protect against morphine-6-glucuronide toxicity?Anesthesiology2002
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Collaborators

Perelman School of Medicine, University of Pennsylvania
Co-authored papers 15
Perelman School of Medicine, University of Pennsylvania Philadelphia
Co-authored papers 7
University of Pennsylvania.
Co-authored papers 6
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 3
Co-authored papers 2
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Dartmouth College Geisel School of Medicine, Princeton University, University of Colorado Anschutz Medical Campus, University of Pennsylvania Perelman School of Medicine
Co-authored papers 2
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Children's Hospital of Philadelphia
Co-authored papers 2
Vagelos College of Physicians and Surgeons, Columbia University
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Center for Spatial and Functional Genomics, Children's Hospital of Philadelphia
Co-authored papers 1
National Institute of Diabetes and Digestive and Kidney Diseases
Co-authored papers 1
Mayo Clinic
Co-authored papers 1
Food Research Center (FoRC)
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
at the University of Pennsylvania Perelman School of Medicine
Co-authored papers 1
Children's Hospital of Philadelphia
Co-authored papers 1
China National Center for Biotechnology Development
Co-authored papers 1
Advanced Institute for Medical Sciences, Dalian Medical University
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Columbia University
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Vanderbilt University Medical Center
Co-authored papers 1
Cincinnati Children's Hospital
Co-authored papers 1
Center for Systems Genomics, Pennsylvania State University, University Park
Co-authored papers 1
and of Biochemistry and Pharmacy, University of Tuebingen
Co-authored papers 1
School of Clinical Medicine, Shanghai University of Medicine and Health Sciences
Co-authored papers 1