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Author Details

Paul N Span
Radboud University Medical Center
1993
244
57
PMIDPaper TitleJournal TitlePublished Year
36755288Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer.Cancer Metab2023
37479706Obesity-associated changes in molecular biology of primary breast cancer.Nat Commun2023
37837609Hormonal control during infancy and testicular adrenal rest tumor development in males with congenital adrenal hyperplasia: a retrospective multicenter cohort study.Eur J Endocrinol2023
37935047Evaluation of Ex Vivo Adrenocorticotropic Hormone Responsiveness of Human Fetal Testis.Endocrinology2023
37190094Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase.Cells2023
36478188Clinical Implications of APOBEC3-Mediated Mutagenesis in Breast Cancer.Clin Cancer Res2023
36882391Quantitative Imaging of Hypoxic CAIX-Positive Tumor Areas with Low Immune Cell Infiltration in Syngeneic Mouse Tumor Models.Mol Pharm2023
34390337Production of 11-Oxygenated Androgens by Testicular Adrenal Rest Tumors.J Clin Endocrinol Metab2022
36578966Challenges in treatment of patients with non-classic congenital adrenal hyperplasia.Front Endocrinol (Lausanne)2022
35896617Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer.Oncogene2022
35150157Diurnal salivary androstenedione and 17-hydroxyprogesterone levels in healthy volunteers for monitoring treatment efficacy of patients with congenital adrenal hyperplasia.Clin Endocrinol (Oxf)2022
34788830Optimizing the Timing of Highest Hydrocortisone Dose in Children and Adolescents With 21-Hydroxylase Deficiency.J Clin Endocrinol Metab2022
33419779Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy.Clin Cancer Res2021
33592541Radiotherapy and cGAS/STING signaling: Impact on MDSCs in the tumor microenvironment.Cell Immunol2021
33815285Quality of Life in Men With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency.Front Endocrinol (Lausanne)2021
33707312Letter to the editor: Hypoxia kinetics and histology in combined radiotherapy and oxidative phosphorylation inhibition effects on antitumor immunity.J Immunother Cancer2021
33918832Improving Breast Cancer Treatment Specificity Using Aptamers Obtained by 3D Cell-SELEX.Pharmaceuticals (Basel)2021
33802339Genotyping and Characterization of HPV Status, Hypoxia, and Radiosensitivity in 22 Head and Neck Cancer Cell Lines.Cancers (Basel)2021
31046897Changes in DNA Damage Repair Gene Expression and Cell Cycle Gene Expression Do Not Explain Radioresistance in Tamoxifen-Resistant Breast Cancer.Oncol Res2020
33511022Tunable Hybrid Matrices Drive Epithelial Morphogenesis and YAP Translocation.Adv Sci (Weinh)2020
32777015Collective invasion induced by an autocrine purinergic loop through connexin-43 hemichannels.J Cell Biol2020
32999851Polyisocyanide Hydrogels as a Tunable Platform for Mammary Gland Organoid Formation.Adv Sci (Weinh)2020
32985974Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B.Elife2020
32477955Editorial: Advances in Biological Understanding of Tumor Radiation Resistance.Front Oncol2020
32337377The tumor microenvironment and radiotherapy response; a central role for cancer-associated fibroblasts.Clin Transl Radiat Oncol2020
32361013AKT inhibition as a strategy for targeting hypoxic HPV-positive HNSCC.Radiother Oncol2020
32394054Prognostic significance of VEGF and components of the plasminogen activator system in endometrial cancer.J Cancer Res Clin Oncol2020
31369816P120 and E-cadherin: Double-edged swords in tumor metastasis.Semin Cancer Biol2020
29493265HPV, hypoxia and radiation response in head and neck cancer.Br J Radiol2019
31817870ACLY (ATP Citrate Lyase) Mediates Radioresistance in Head and Neck Squamous Cell Carcinomas and is a Novel Predictive Radiotherapy Biomarker.Cancers (Basel)2019
31668020Glucose and glutamine metabolism in relation to mutational status in NSCLC histological subtypes.Thorac Cancer2019
31676589BRAF<sup>V600E</sup> Inhibitor Radiosensitizes Thyroid Cancer-Letter.Clin Cancer Res2019
30001166Isocitrate dehydrogenase 1-mutated human gliomas depend on lactate and glutamate to alleviate metabolic stress.FASEB J2019
31615071The Role of Hypoxia and the Immune System in Tumor Radioresistance.Cancers (Basel)2019
31271827Inhibition of CDK4/CDK6 Enhances Radiosensitivity of HPV Negative Head and Neck Squamous Cell Carcinomas.Int J Radiat Oncol Biol Phys2019
31406196HER2, chromosome 17 polysomy and DNA ploidy status in breast cancer; a translational study.Sci Rep2019
31317787Downregulation of matrix Gla protein is a biomarker for tamoxifen-resistant and radioresistant breast cancer.Biomark Med2019
31569498P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis.Cancers (Basel)2019
31090904Glucocorticoid Activity of Adrenal Steroid Precursors in Untreated Patients With Congenital Adrenal Hyperplasia.J Clin Endocrinol Metab2019
30882882Testicular Adrenal Rest Tumors: Current Insights on Prevalence, Characteristics, Origin, and Treatment.Endocr Rev2019
31139406<i>Isocitrate dehydrogenase 1</i>-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate.Cancer Metab2019
30723127Polyomavirus T Antigen Induces <i>APOBEC3B</i> Expression Using an LXCXE-Dependent and TP53-Independent Mechanism.mBio2019
30643202Differential expression of p120-catenin 1 and 3 isoforms in epithelial tissues.Sci Rep2019
29339528Gonadal function in adult male patients with congenital adrenal hyperplasia.Eur J Endocrinol2018
30002742Predicting and Understanding Cancer Response to Treatment.Dis Markers2018
30252041Mutational mechanisms of amplifications revealed by analysis of clustered rearrangements in breast cancers.Ann Oncol2018
30527190Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer.Lung Cancer2018
29661777Interferon-Stimulated Genes Are Involved in Cross-resistance to Radiotherapy in Tamoxifen-Resistant Breast Cancer.Clin Cancer Res2018
27993570Radiation oncology enters the era of individualised medicine.Lancet Oncol2017
28329761Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.Nature2017
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Collaborators

Fred C G J Sweep
Radboud University Medical Centre
Co-authored papers 139
Johan Bussink
Radboud University, Nijmegen Medical Centre
Co-authored papers 71
Johannes H A M Kaanders
Radboud University Medical Center
Co-authored papers 38
John W M Martens
Erasmus Medical Center (MC) Cancer Institute
Co-authored papers 29
Hanneke W M van Laarhoven
Cancer Center Amsterdam
Co-authored papers 15
Albert J van der Kogel
University of Wisconsin School of Medicine and Public Health
Co-authored papers 13
Serena Nik-Zainal
Early Cancer Institute, University of Cambridge
Co-authored papers 10
Sunil R Lakhani
University of Queensland
Co-authored papers 9
Andrea L Richardson
Co-authored papers 9
Anne-Lise B??rresen-Dale
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 8
Carlos Caldas
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 7
Laura J Van't Veer
University of California San Francisco
Co-authored papers 7
Peter J Campbell
Wellcome Sanger Institute
Co-authored papers 7
Manasa Ramakrishna
Co-authored papers 7
Christos Sotiriou
Co-authored papers 6
Gilles Thomas
Co-authored papers 6
Michael R Stratton
Wellcome Sanger Institute
Co-authored papers 6
Peter Bult
Radboud University Medical Center
Co-authored papers 5
Reuben S Harris
University of Texas Health San Antonio
Co-authored papers 5
Bradly G Wouters
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
Co-authored papers 5
Peter T Simpson
UQ Centre for Clinical Research, The University of Queensland
Co-authored papers 5
Moritz Gerstung
German Cancer Research Centre DKFZ
Co-authored papers 5
Ludmil B Alexandrov
Moores Cancer Center, university of california san diego
Co-authored papers 4
Ewan Birney
European Bioinformatics Institute
Co-authored papers 4
Carolien H M van Deurzen
Erasmus MC Cancer Institute
Co-authored papers 4
Samuel Aparicio
University of British Columbia
Co-authored papers 4
Dominik Glodzik
Co-authored papers 4
Adam Butler
Wellcome Sanger Institute
Co-authored papers 4
Sarah O'Meara
Clinical Research Facility, Mercy University Hospital
Co-authored papers 3
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