Author details

Full Name

Philippe Froguel

Affiliation

ORCID

Career Start Year

1987

Papers

709

H Index

144

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36980190	High-Throughput Quantitative Screening of Glucose-Stimulated Insulin Secretion and Insulin Content Using Automated MALDI-TOF Mass Spectrometry.		2023
38028628	Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.	Front Genet	2023
37659411	High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor.		2023
37730687	Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide.	Nat Commun	2023
37638789	Identification of myokines susceptible to improve glucose homeostasis after bariatric surgery.		2023
37978231	Genetic variants of interferon-response factor 5 are associated with the incidence of chronic kidney disease: the D.E.S.I.R. study.		2023
37709961	Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.	Nat Metab	2023
38051360	Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas.		2023
37216637	Î²-Cell-Specific E2f1 Deficiency Impairs Glucose Homeostasis, Î²-Cell Identity, and Insulin Secretion.		2023
37092539	Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use.		2023
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
37083980	Biallelic Mutations in P4HTM Cause Syndromic Obesity.		2023
36894549	Monogenic diabetes.		2023
36822744	Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study.		2023
37137910	Identification of biomarkers for glycaemic deterioration in type 2 diabetes.	Nat Commun	2023
36922513	A rare human variant that disrupts GPR10 signalling causes weight gain in mice.		2023
37039251	Control of human pancreatic beta cell kinome by glucagon-like peptide-1 receptor biased agonism.		2023
37502937	Multiple genetic variants at the locus affect local super-enhancer activity and influence pancreatic Î²-cell survival and function.		2023
37496675	Pharmacological HDAC inhibition impairs pancreatic Î²-cell function through an epigenome-wide reprogramming.		2023
37494602	Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes.		2023
37161092	Abdominal obesity is a more important causal risk factor for pancreatic cancer than overall obesity.		2023
36980212	Knocking Down in 3D hiPSC-Derived Brown Adipose Progenitors Potentiates Differentiation, Oxidative Metabolism and Browning Process.		2023
35053407	Glucose Regulates mA Methylation of RNA in Pancreatic Islets.	Cells	2022
35846981	Structural Elements Directing G Proteins and Î²-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.	ACS Pharmacol Transl Sci	2022
35947949	The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic Î² cells.	Cell Reports	2022
35806330	Epigenetic and Transcriptomic Programming of HSC Quiescence Signaling in Large for Gestational Age Neonates.	International Journal of Molecular Sciences	2022
35624321	Management of pregnancy in a patient with congenital hyperinsulinism treated with association of diazoxide/calcium channel blocker.	Acta Diabetologica	2022
35427775	Epigenetic changes associated with hyperglycaemia exposure in the longitudinal D.E.S.I.R. cohort.		2022
35551307	Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.	Nat Genet	2022
36050321	Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.	Nat Commun	2022
36536131	The discovery of human agouti-induced obesity and its implication for genetic diagnosis.		2022
35227307	Compound genetic etiology in a patient with a syndrome including diabetes, intellectual deficiency and distichiasis.	Orphanet Journal of Rare Diseases	2022
34718610	Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia.	J Clin Endocrinol Metab	2022
35148896	How has the future investment program stimulated research and innovation in health?	Therapies	2022
35115415	Dominant negative mutation in oxalate transporter associated with enteric hyperoxaluria and nephrolithiasis.	Journal of Medical Genetics	2022
35106505	Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study.	Cell Rep Med	2022
35104326	Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies.	Diabetes Care	2022
35061034	Rare Variant Analysis of Obesity-Associated Genes in Young Adults With Severe Obesity From a Consanguineous Population of Pakistan.		2022
35220425	Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes.	Hum Mol Genet	2022
34661078	Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.	ACS Pharmacol Transl Sci	2021
32189007	The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development.	Cellular and Molecular Life Sciences	2021
33910978	SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations.	Science Translational Medicine	2021
34116986	Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.	Diabetes Care	2021
33737653	Triangulating evidence from longitudinal and Mendelian randomization studies of metabolomic biomarkers for type 2 diabetes.	Sci Rep	2021
33526906	Clustering for a better prediction of type 2 diabetes mellitus.	Nature Reviews Endocrinology	2021
33730570	Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion.	Cell Reports	2021
34196129	Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle.	J Cachexia Sarcopenia Muscle	2021
33558525	Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.	Nat Commun	2021
33242514	Monogenic diabetes characteristics in a transnational multicenter study from Mediterranean countries.	Diabetes Research and Clinical Practice	2021
33402679	Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.	Nat Commun	2021