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Author Details

Allan B Okey
University of Toronto
1968
118
49
PMIDPaper TitleJournal TitlePublished Year
31511937Comparative toxicoproteogenomics of mouse and rat liver identifies TCDD-resistance genes.Arch Toxicol2019
271368982,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity.Arch Toxicol2017
28086803Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems.BMC Genomics2017
25529477Transcriptional profiling of rat hypothalamus response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin.Toxicology2015
26232522Transcriptional profiling of rat white adipose tissue response to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin.Toxicol Appl Pharmacol2015
24355419TCDD dysregulation of 13 AHR-target genes in rat liver.Toxicol Appl Pharmacol2014
25467400Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity.BMC Genomics2014
23169800Systematic evaluation of medium-throughput mRNA abundance platforms.RNA2013
22342509Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).Toxicol Appl Pharmacol2012
21215274Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity.Toxicol Appl Pharmacol2011
21760882mRNA levels in control rat liver display strain-specific, hereditary, and AHR-dependent components.PLoS One2011
20420666Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities.BMC Genomics2010
20570689Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver.Toxicol Appl Pharmacol2010
18394668Genome-wide effects of acute progressive feed restriction in liver and white adipose tissue.Toxicol Appl Pharmacol2008
18765683Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver.Drug Metab Dispos2008
18796159Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse.BMC Genomics2008
18990750Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.Cancer Epidemiol Biomarkers Prev2008
18465118Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats.Arch Toxicol2008
17698510microRNAs in adult rodent liver are refractory to dioxin treatment.Toxicol Sci2007
17569696An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI.Toxicol Sci2007
17636048Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transactivational activity.Mol Pharmacol2007
16214954Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries.Mol Pharmacol2006
17116718Dietary phytoestrogen intake is associated with reduced colorectal cancer risk.J Nutr2006
17013924Microarray analysis of the developing cortex.J Neurobiol2006
16794816Advances in analytical techniques for polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and dioxin-like PCBs.Anal Bioanal Chem2006
16488401Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor.Biochem Pharmacol2006
16466705Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats.Chem Biol Interact2006
16497791Differential expression profiling of the hepatic proteome in a rat model of dioxin resistance: correlation with genomic and transcriptomic analyses.Mol Cell Proteomics2006
15993909Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor.Toxicol Appl Pharmacol2005
16420732Unsupervised pattern recognition: an introduction to the whys and wherefores of clustering microarray data.Brief Bioinform2005
15900209Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes.Pharmacogenet Genomics2005
16097792Gene expression profiling in a model of D-penicillamine-induced autoimmunity in the Brown Norway rat: predictive value of early signs of danger.Chem Res Toxicol2005
15028720Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.J Biol Chem2004
15358164Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting.Biochem Biophys Res Commun2004
15047159AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells.Biochem Biophys Res Commun2004
15073008PUNS: transcriptomic- and genomic-in silico PCR for enhanced primer design.Bioinformatics2004
12213390Polymorphisms in the human AH receptor.Chem Biol Interact2002
12185560Modeling of human hepatic CYP3A4 enzyme kinetics, protein, and mRNA indicates deviation from log-normal distribution in CYP3A4 gene expression.Eur J Clin Pharmacol2002
11509025Persistent, low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effect on aryl hydrocarbon receptor expression in a dioxin-resistance model.Toxicol Appl Pharmacol2001
11207035Ethnic variability in the allelic distribution of human aryl hydrocarbon receptor codon 554 and assessment of variant receptor function in vitro.Pharmacogenetics2001
11755109In vivo up-regulation of aryl hydrocarbon receptor expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a dioxin-resistant rat model.Biochem Pharmacol2001
11689007Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.Biochem Biophys Res Commun2001
11763009Treatment-resistance to clozapine in association with ultrarapid CYP1A2 activity and the C-->A polymorphism in intron 1 of the CYP1A2 gene: effect of grapefruit juice and low-dose fluvoxamine.J Clin Psychopharmacol2001
10860547Comparative induction of CYP1A1 expression by pyridine and its metabolites.Arch Biochem Biophys2000
10036221Physicochemical differences in the AH receptors of the most TCDD-susceptible and the most TCDD-resistant rat strains.Toxicol Appl Pharmacol1999
9783729Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.Biochem Pharmacol1998
9658193Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain.Mol Pharmacol1998
9514084Prolonged depletion of AH receptor without alteration of receptor mRNA levels after treatment of cells in culture with 2,3,7,8-tetrachlorodibenzo-p-dioxin.Biochem Pharmacol1998
9134685Binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin to AH receptor in placentas from normal versus abnormal pregnancy outcomes.Chemosphere1997
7600448Aromatic hydrocarbon receptor in cultured fetal cells from C57BL/6J and DBA/2J mice: similarity in molecular mass to receptors in adult livers.Can J Physiol Pharmacol1995
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Collaborators

University of Toronto.
Co-authored papers 28
University of California los angeles
Co-authored papers 27
Department of Food Hygiene and Environmental Health, University of Helsinki
Co-authored papers 27
University of Toronto
Co-authored papers 17
University Health Network
Co-authored papers 10
Ontario Institute for Cancer Research
Co-authored papers 8
Biomedicine Discovery Institute, Monash University
Co-authored papers 8
University of Helsinki
Co-authored papers 7
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University of Toronto
Co-authored papers 6
College of Veterinary Medicine, Kansas State University
Co-authored papers 5
Ontario Institute for Cancer Research
Co-authored papers 4
University of Jyvaskyla
Co-authored papers 4
Children's Hospital
Co-authored papers 4
Ontario Institute for Cancer Research, University of Toronto
Co-authored papers 4
University of California los angeles
Co-authored papers 4
University of British Columbia
Co-authored papers 3
Ontario Institute for Cancer Research
Co-authored papers 3
The Hospital for Sick Children
Co-authored papers 3
Ontario Institute for Cancer Research, University Avenue
Co-authored papers 3
University Avenue
Co-authored papers 3
University of Toronto
Co-authored papers 3
Big Data Institute, University of Oxford
Co-authored papers 2
Western University
Co-authored papers 2
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
Co-authored papers 2
Institute of Basic Medical Sciences, University of Oslo
Co-authored papers 2
School of Pharmacy (Toxicology), University of Eastern Finland
Co-authored papers 2
Finnish Institute for Health and Welfare (THL)
Co-authored papers 2
University of Toronto
Co-authored papers 1
IRCCS-Istituto di Ricerche Farmacologiche Mario Negri
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