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Author Details

Ronen Marmorstein
Perelman School of Medicine, University of Pennsylvania
1987
221
74
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36638802Molecular role of NAA38 in thermostability and catalytic activity of the human NatC N-terminal acetyltransferase.Structure2023
37024283Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia.Genes Dev2023
37319422Semi-Synthetic CoA-α-Synuclein Constructs Trap N-Terminal Acetyltransferase NatB for Binding Mechanism Studies.J Am Chem Soc2023
37076498Allosteric role of the citrate synthase homology domain of ATP citrate lyase.Nat Commun2023
37130971Expanding the phenotypic spectrum of NAA10-related neurodevelopmental syndrome and NAA15-related neurodevelopmental syndrome.Eur J Hum Genet2023
37066334Semi-synthetic CoA-α-Synuclein Constructs Trap N-terminal Acetyltransferase NatB for Binding Mechanism Studies.bioRxiv2023
36063997The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity.J Biol Chem2022
35858355Allosteric role of a structural NADP<sup>+</sup> molecule in glucose-6-phosphate dehydrogenase activity.Proc Natl Acad Sci U S A2022
32912665Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation.Trends Biochem Sci2021
33509943Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.Cancer Res2021
33631370Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.Bioorg Med Chem Lett2021
34408321DAXX represents a new type of protein-folding enabler.Nature2021
34732320N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate.J Biol Chem2021
34423187Unfolding Mechanisms and Conformational Stability of the Dimeric Endophilin N-BAR Domain.ACS Omega2021
34715128The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation.J Biol Chem2021
34019809Molecular mechanism of N-terminal acetylation by the ternary NatC complex.Structure2021
34294921Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.Nat Struct Mol Biol2021
34110812Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D.J Med Chem2021
34355692<i>Naa12</i> compensates for <i>Naa10</i> in mice in the amino-terminal acetylation pathway.Elife2021
33139506The MEK/ERK Network as a Therapeutic Target in Human Cancer.Mol Cancer Res2021
32242119Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase.Nat Struct Mol Biol2020
34141066Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.ACS Med Chem Lett2020
31873304Molecular basis for acetyl-CoA production by ATP-citrate lyase.Nat Struct Mol Biol2020
32027362Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15.Hum Mol Genet2020
31742863Rap1-mediated nucleosome displacement can regulate gene expression in senescent cells without impacting the pace of senescence.Aging Cell2020
32042062Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK.Nat Commun2020
32885784Molecular basis for N-terminal alpha-synuclein acetylation by human NatB.Elife2020
30442709PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer.Cancer Discov2019
31606079Biochemical and structural analysis of N-terminal acetyltransferases.Methods Enzymol2019
31155310Structure and Mechanism of Acetylation by the N-Terminal Dual Enzyme NatA/Naa50 Complex.Structure2019
31040182The HIRA histone chaperone complex subunit UBN1 harbors H3/H4- and DNA-binding activity.J Biol Chem2019
30877197ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis.J Biol Chem2019
30350439Molecular basis for chromatin assembly and modification by multiprotein complexes.Protein Sci2019
29409905CTCF-Induced Circular DNA Complexes Observed by Atomic Force Microscopy.J Mol Biol2018
30082790Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit.Nat Commun2018
29992710Mechanism of BRAF Activation through Biochemical Characterization of the Recombinant Full-Length Protein.Chembiochem2018
30099988Structural Basis for MARK1 Kinase Autoinhibition by Its KA1 Domain.Structure2018
30084538Actin's N-terminal acetyltransferase uncovered.Cytoskeleton (Hoboken)2018
29754825Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.Structure2018
29727562N-(7-Cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide (TAK632) Promotes Inhibition of BRAF through the Induction of Inhibited Dimers.J Med Chem2018
29581307Structural determinants and cellular environment define processed actin as the sole substrate of the N-terminal acetyltransferase NAA80.Proc Natl Acad Sci U S A2018
29382722The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate.J Biol Chem2018
29769713Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.Nature2018
27871933A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function.J Mol Biol2017
28953875Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.Nature2017
29070843Characterization of histone acylations links chromatin modifications with metabolism.Nat Commun2017
29348807Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases.ACS Med Chem Lett2017
28972186Intramolecular autoinhibition of checkpoint kinase 1 is mediated by conserved basic motifs of the C-terminal kinase-associated 1 domain.J Biol Chem2017
29016658Probing the interaction between NatA and the ribosome for co-translational protein acetylation.PLoS One2017
28899863A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.Cancer Discov2017
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Collaborators

Shelley L Berger
Penn Epigenetics Institute, Perelman School of Medicine
Co-authored papers 16
Philip A Cole
Brigham and Women's Hospital, Blavatnik Institute, Harvard Medical School
Co-authored papers 14
David W Speicher
Co-authored papers 10
Peter D Adams
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 7
Meenhard Herlyn
Ellen and Ronald Caplan Cancer Center, The Wistar Institute
Co-authored papers 6
C David Allis
The Rockefeller University
Co-authored papers 4
Keqin Li
Institute of Animal Genetics and Breeding, Sichuan Agricultural University
Co-authored papers 4
Gholson J Lyon
NYS Institute for Basic Research in Developmental Disabilities .
Co-authored papers 4
Kenneth D Bromberg
Co-authored papers 4
Hualiang Jiang
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Co-authored papers 3
Andrzej Joachimiak
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 3
Lorraine Pillus
University of California San Diego
Co-authored papers 2
James Shorter
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 2
Melanie Ott
Gladstone Institute of Virology
Co-authored papers 2
Stefan Knapp
Institute of Pharmaceutical Chemistry, Goethe University
Co-authored papers 2
Anastasia Wyce
Collegeville
Co-authored papers 2
Ramana V Davuluri
The Wistar Institute
Co-authored papers 2
Gao Zhang
Co-authored papers 2
Chunaram Choudhary
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Co-authored papers 2
Virginia M-Y Lee
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 2
Jacques C??t??
Centre Hospitalier Universitaire (CHU) de Quebec-Universite Laval Research Center
Co-authored papers 2
Catherine Dargemont
Institute of Human Genetics, UMR 9002 CNRS - University of Montpellier
Co-authored papers 2
Tamar Uziel
AbbVie Inc.
Co-authored papers 2
Karl W Henry
The Wistar Institute
Co-authored papers 1
Kevan M Shokat
University of California San Francisco
Co-authored papers 1
Robert J Cotter
Co-authored papers 1
Linda Z Penn
University of Toronto
Co-authored papers 1
William A Weiss
University of California san francisco
Co-authored papers 1
Joshua D Rabinowitz
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Release 1.2