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Author Details

Michael E Ward
National Institute of Neurological, National Institutes of Health (NIH)
2011
52
26
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36778383DLK-dependent axonal mitochondrial fission drives degeneration following axotomy.bioRxiv2024
36865171Multi-modal Proteomic Characterization of Lysosomal Function and Proteostasis in Progranulin-Deficient Neurons.bioRxiv2023
37545108Cognitive determinants of decisional capacity in neurodegenerative disorders.Ann Clin Transl Neurol2023
37974165Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.Mol Neurodegener2023
36993242ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes.bioRxiv2023
37409055Application of Aligned-UMAP to longitudinal biomedical studies.Patterns (N Y)2023
37168844Variant biomarker discovery using mass spectrometry-based proteogenomics.Front Aging2023
36922834The era of cryptic exons: implications for ALS-FTD.Mol Neurodegener2023
36747793Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.bioRxiv2023
36869920Correction: LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size.Cell Mol Life Sci2023
36707427LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size.Cell Mol Life Sci2023
35139144Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids.J Cell Biol2022
35395199Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.Mol Cell2022
36576240Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.Elife2022
36459969A reference human induced pluripotent stem cell line for large-scale collaborative studies.Cell Stem Cell2022
35953545A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.Nat Neurosci2022
35063084Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.Cell2022
35145299The threat of programmed DNA damage to neuronal genome integrity and plasticity.Nat Genet2022
35197628TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.Nature2022
33940617miR-936 is Increased in Schizophrenia and Inhibits Neural Development and AMPA Receptor-Mediated Synaptic Transmission.Schizophr Bull2021
33767446Neuronal enhancers are hotspots for DNA single-strand break repair.Nature2021
33510479RNA transport and local translation in neurodevelopmental and neurodegenerative disease.Nat Neurosci2021
33831364Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH.Neuron2021
34824257Axonal TDP-43 condensates drive neuromuscular junction disruption through inhibition of local synthesis of nuclear encoded mitochondrial proteins.Nat Commun2021
34403849Bioengineered optogenetic model of human neuromuscular junction.Biomaterials2021
34804862Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function.Int J Ophthalmol2021
34680045Deficiency of the Lysosomal Protein CLN5 Alters Lysosomal Function and Movement.Biomolecules2021
34592985A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1.BMC Biol2021
31603614ToolBox: Live Imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons.Traffic2020
31968264Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells.Cell Rep2020
31719114Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover.J Cell Biol2020
33207181Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain.Mol Cell2020
33201688Development and Comparative Evaluation of Endolysosomal Proximity Labeling-Based Proteomic Methods in Human iPSC-Derived Neurons.Anal Chem2020
32790644Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia.J Clin Invest2020
30765536Heterochromatin anomalies and double-stranded RNA accumulation underlie <i>C9orf72</i> poly(PR) toxicity.Science2019
31704179Lysosomal Dysfunction at the Centre of Parkinson's Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.Trends Neurosci2019
31422865CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.Neuron2019
29400714Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.Nat Med2018
30053424The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.Cell2018
29924488Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.Curr Protoc Cell Biol2018
29518257Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment.Ann Neurol2018
28068565Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults.Neurobiol Aging2017
28438992Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.Proc Natl Acad Sci U S A2017
28404863Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.Sci Transl Med2017
28966121Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.Stem Cell Reports2017
29198827Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.Stem Cell Reports2017
25589773SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.J Neurosci2015
25155018Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.J Exp Med2014
25261995Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.Nat Med2014
23775919Glaucoma and dementia: more than meets the eye?Ann Neurol2013
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Collaborators

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Co-authored papers 10
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Dokkyo Medical University
Co-authored papers 6
Martin Kampmann
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Co-authored papers 6
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Co-authored papers 5
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Leonard Petrucelli
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University of Antwerp
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May Christine V Malicdan
National Human Genome Research Institute, National Institutes of Health
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Richard J Youle
Co-authored papers 2
Tejal A Desai
University of California San Francisco
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William W Seeley
UCSF Weill Institute for Neurosciences, University of California san francisco
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Anna L Brown
Adelaide Medical School, University of Adelaide
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Ruth H??ttenhain
Quantitative Biosciences Institute (QBI), University of California san francisco
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Bruce R Conklin
Gladstone Institutes
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Xu Chen
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Yaqiao Li
Harvard Medical School
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Giovanni Coppola
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Tania F Gendron
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Release 1.2