Author details

Full Name

Edward M Scolnick

Affiliation

ORCID

Career Start Year

1962

Papers

274

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
35022400	Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues.	Nat Commun	2022
35396579	Rare coding variants in ten genes confer substantial risk for schizophrenia.	Nature	2022
35505090	Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility.	Mol Psychiatry	2022
35260802	The schizophrenia-associated variant in SLC39A8 alters protein glycosylation in the mouse brain.	Mol Psychiatry	2022
33409479	Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.	iScience	2020
32434848	Selective inhibition of glycogen synthase kinase 3Î± corrects pathophysiology in a mouse model of fragile X syndrome.	Sci Transl Med	2020
32377000	Glycobiology and schizophrenia: a biological hypothesis emerging from genomic research.	Mol Psychiatry	2020
32404945	Aberrant glycosylation in schizophrenia: a review of 25 years of post-mortem brain studies.	Mol Psychiatry	2020
32753748	The schizophrenia risk locus in SLC39A8 alters brain metal transport and plasma glycosylation.	Sci Rep	2020
29515000	Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia.	Sci Transl Med	2018
29945886	Molecular mechanisms of the preventable causes of cancer in the United States.	Genes Dev	2018
29485852	Functionally Biased D2R Antagonists: Targeting the Î²-Arrestin Pathway to Improve Antipsychotic Treatment.	ACS Chemical Biology	2018
29484180	A vaccine to prevent cervical cancer: academic and industrial collaboration and a Lasker award.	Clinical and Translational Immunology	2018
27869829	Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.	Nat Genet	2017
28360375	The Path to New Therapies for Schizophrenia and Bipolar Illness.	FASEB Journal	2017
27457813	Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.	Mol Psychiatry	2017
28194006	Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.	Mol Psychiatry	2017
26503763	Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder.	Mol Psychiatry	2016
27128528	Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.	ACS Chem Biol	2016
26196440	Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.	Transl Psychiatry	2015
25642316	Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers.	Chem Sci	2015
24776740	Copy number variation in schizophrenia in Sweden.	Mol Psychiatry	2014
24474471	An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis.	Hum Mol Genet	2014
24463508	A polygenic burden of rare disruptive mutations in schizophrenia.	Nature	2014
24463507	De novo mutations in schizophrenia implicate synaptic networks.	Nature	2014
23933821	Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.	Nat Genet	2013
23868113	Validating therapeutic targets through human genetics.	Nat Rev Drug Discov	2013
23974872	Genome-wide association analysis identifies 13 new risk loci for schizophrenia.	Nat Genet	2013
22688191	Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.	Mol Psychiatry	2012
21802010	AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.	Chem Biol	2011
21389981	AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.		2011
20838396	GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia.	Mol Psychiatry	2011
20351715	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	Mol Psychiatry	2011
20495671	Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling.	ACS Chem Neurosci	2010
19693800	Support of association between BRD1 and both schizophrenia and bipolar affective disorder.	Am J Med Genet B Neuropsychiatr Genet	2010
20339051	Medicine. The future of psychiatric research: genomes and neural circuits.	Science	2010
19557189	Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.	PLoS Genet	2009
19448189	A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.	Am J Psychiatry	2009
18711365	Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.	Nat Genet	2008
18317468	Whole-genome association study of bipolar disorder.	Mol Psychiatry	2008
17033966	Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.	Am J Hum Genet	2006
16760370	A cell-based ultra-high-throughput screening assay for identifying inhibitors of D-amino acid oxidase.	Journal of Biomolecular Screening	2006
16863597	Recurrence risks for schizophrenia in a Swedish national cohort.	Psychol Med	2006
16355250	Cure therapeutics and strategic prevention: raising the bar for mental health research.	Molecular Psychiatry	2006
16616720	Mechanisms of action of medicines for schizophrenia and bipolar illness: status and limitations.	Biological Psychiatry	2006
16338135	The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection.	Bioorganic and Medicinal Chemistry Letters	2006
16603473	Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model?	Harvard Review of Psychiatry	2006
15797548	Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex.	Neuron	2005
15911756	Anthrax lethal factor inhibition.	Proceedings of the National Academy of Sciences of the United States of America	2005
15006136	High-throughput cell-based screening using scintillation proximity assay for the discovery of inositol phosphatase inhibitors.	Journal of Biomolecular Screening	2004