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Author Details

Christoph J Fahrni
Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
1997
51
27
Sami Nourreddine (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36661323Conformationally Preorganized High-Affinity Ligands for Copper Biology with Hinged and Rigid Thiophene Backbones.Inorg Chem2023
37788545Editorial overview: Imaging metal ions in biological systems.Curr Opin Chem Biol2023
37546881Developmental regulation of zinc homeostasis in differentiating oligodendrocytes.bioRxiv2023
36291910High-Affinity Cu(I)-Chelator with Potential Anti-Tumorigenic Action-A Proof-of-Principle Experimental Study of Human H460 Tumors in the CAM Assay.Cancers (Basel)2022
33978414Optically Modulated and Optically Activated Delayed Fluorescent Proteins through Dark State Engineering.J Phys Chem B2021
32469032Transmembrane Cu(I) P-type ATPase pumps are electrogenic uniporters.Dalton Trans2020
32709883Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer.Nat Commun2020
31160463Ratiometric two-photon microscopy reveals attomolar copper buffering in normal and Menkes mutant cells.Proc Natl Acad Sci U S A2019
31575910High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent.Sci Rep2019
31059767Zinc homeostasis and zinc signaling in white matter development and injury.Neurosci Lett2019
30928671Trafficking mechanisms of P-type ATPase copper transporters.Curr Opin Cell Biol2019
29431427Chromis-1, a Ratiometric Fluorescent Probe Optimized for Two-Photon Microscopy Reveals Dynamic Changes in Labile Zn(II) in Differentiating Oligodendrocytes.ACS Sens2018
29885022Stabilization of Aliphatic Phosphines by Auxiliary Phosphine Sulfides Offers Zeptomolar Affinity and Unprecedented Selectivity for Probing Biological Cu<sup>I</sup>.Angew Chem Int Ed Engl2018
29101230Glutathione limits aquacopper(I) to sub-femtomolar concentrations through cooperative assembly of a tetranuclear cluster.J Biol Chem2017
27531414MicroXRF tomographic visualization of zinc and iron in the zebrafish embryo at the onset of the hatching period.Metallomics2016
28042469Rational Design of a Water-Soluble, Lipid-Compatible Fluorescent Probe for Cu(I) with Sub-Part-Per-Trillion Sensitivity.Chem Sci2016
26402244Optically Modulated Photoswitchable Fluorescent Proteins Yield Improved Biological Imaging Sensitivity.J Am Chem Soc2015
26330090Fluorogenic Strain-Promoted Alkyne-Diazo Cycloadditions.Chemistry2015
249928313D imaging of transition metals in the zebrafish embryo by X-ray fluorescence microtomography.Metallomics2014
25313708Probing ternary complex equilibria of crown ether ligands by time-resolved fluorescence spectroscopy.J Phys Chem B2014
23212029Subcellular redistribution and mitotic inheritance of transition metals in proliferating mouse fibroblast cells.Metallomics2013
24298878Robust affinity standards for Cu(I) biochemistry.J Am Chem Soc2013
23769869Synthetic fluorescent probes for monovalent copper.Curr Opin Chem Biol2013
23169532High-contrast fluorescence sensing of aqueous Cu(I) with triarylpyrazoline probes: dissecting the roles of ligand donor strength and excited state proton transfer.Dalton Trans2013
23095037A fluorogenic probe for the catalyst-free detection of azide-tagged molecules.J Am Chem Soc2012
23419973Signal Discrimination Between Fluorescent Proteins in Live Cells by Long-wavelength Optical Modulation.J Phys Chem Lett2012
231044559-Aryl-9-xanthenols: a convenient platform for the design of fluorimetric and colorimetric pH indicators.Org Biomol Chem2012
21949587High-contrast Cu(I)-selective fluorescent probes based on synergistic electronic and conformational switching.Chem Sci2011
28503029Metal Ion-Responsive Fluorescent Probes for Two-Photon Excitation Microscopy.Chem Mater2011
21916472Designed to dissolve: suppression of colloidal aggregation of Cu(I)-selective fluorescent probes in aqueous buffer and in-gel detection of a metallochaperone.J Am Chem Soc2011
20020716Kinetically controlled photoinduced electron transfer switching in Cu(I)-responsive fluorescent probes.J Am Chem Soc2010
19865834Copper redistribution in Atox1-deficient mouse fibroblast cells.J Biol Inorg Chem2010
20066271Electronically tuned 1,3,5-triarylpyrazolines as Cu(I)-selective fluorescent probes.Org Biomol Chem2010
19343239Predicting the photoinduced electron transfer thermodynamics in polyfluorinated 1,3,5-triarylpyrazolines based on multiple linear free energy relationships.Org Biomol Chem2009
29104302Fluorescent Probes and Labels for Cellular Imaging.Chimia (Aarau)2009
19772288In situ imaging of metals in cells and tissues.Chem Rev2009
18476714Anomalous photophysics of bis(hydroxystyryl)benzenes: a twist on the para/meta dichotomy.Org Lett2008
18767839Differential tuning of the electron transfer parameters in 1,3,5-triarylpyrazolines: a rational design approach for optimizing the contrast ratio of fluorescent probes.J Am Chem Soc2008
18507462Molecular recognition based on low-affinity polyvalent interactions: selective binding of a carboxylated polymer to fibronectin fibrils of live fibroblast cells.J Am Chem Soc2008
17489564Excited state intramolecular proton transfer in 2-(2'-arylsulfonamidophenyl)benzimidazole derivatives: insights into the origin of donor substituent-induced emission energy shifts.J Phys Chem A2007
17523666Excited-state intramolecular proton transfer in 2-(2'-arylsulfonamidophenyl)benzimidazole derivatives: the effect of donor and acceptor substituents.J Org Chem2007
17845038Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness.J Am Chem Soc2007
17353139Biological applications of X-ray fluorescence microscopy: exploring the subcellular topography and speciation of transition metals.Curr Opin Chem Biol2007
16473527Correlative microXRF and optical immunofluorescence microscopy of adherent cells labeled with ultrasmall gold particles.J Struct Biol2006
16061820Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy.Proc Natl Acad Sci U S A2005
15214085Zinc(II)-selective ratiometric fluorescent sensors based on inhibition of excited-state intramolecular proton transfer.Chemistry2004
15264794A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: modulation of the fluorescence emission via 3(n,pi)-1(pi,pi) inversion.J Am Chem Soc2004
12656613Tuning the photoinduced electron-transfer thermodynamics in 1,3,5-triaryl-2-pyrazoline fluorophores: X-ray structures, photophysical characterization, computational analysis, and in vivo evaluation.J Am Chem Soc2003
12895116X-ray structures, photophysical characterization, and computational analysis of geometrically constrained copper(I)--phenanthroline complexes.Inorg Chem2003
10631609The chemical cell biology of zinc: structure and intracellular fluorescence of a zinc-quinolinesulfonamide complex.J Biol Inorg Chem1999
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Collaborators

Co-authored papers 2
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Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 1
University of Texas MD Anderson Cancer Center
Co-authored papers 1
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Co-authored papers 1
University of Toronto
Co-authored papers 1
IRIC - University of Montreal
Co-authored papers 1
McGill University
Co-authored papers 1
IRIC - University of Montreal
Co-authored papers 1
Institute for Research in Immunology and Cancer (IRIC), University of Montreal
Co-authored papers 1