Author details

Full Name

James A Olzmann

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38019608	Small-molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states.	Mol Biol Cell	2024
37494933	Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.	Dev Cell	2023
37745470	Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states.	bioRxiv	2023
37963466	Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest.		2023
37963395	Lipid Quality Control and Ferroptosis: From Concept to Mechanism.		2023
37000620	Protocol for performing pooled CRISPR-Cas9 loss-of-function screens.		2023
37178691	Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis.	Cell Chem Biol	2023
37502927	A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2.	bioRxiv	2023
35134345	The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.	Dev Cell	2022
35637349	Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.	Nat Chem Biol	2022
36147729	VPS13A and VPS13C Influence Lipid Droplet Abundance.	Contact (Thousand Oaks)	2022
36270234	Context-dependent regulation of ferroptosis sensitivity.	Cell Chem Biol	2022
35672488	End of the road: from the ER to the proteasome.	Nature Reviews Molecular Cell Biology	2022
36409314	A genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity.	Biology Open	2022
36525952	Hydropersulfides are endogenous antioxidants that inhibit ferroptosis.		2022
34547228	More Metabolism!	Mol Cell	2021
34151299	Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics in cultured human cells.	STAR Protocols	2021
34348094	Ending on a sour note: Lipids orchestrate ferroptosis in cancer.		2021
33021827	Protein Quality Control and Lipid Droplet Metabolism.	Annual Review of Cell and Developmental Biology	2020
31932722	Going through a phase.	Nature Chemical Biology	2020
32160526	A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.	Cell	2020
33253074	Diversity through equity and inclusion: The responsibility belongs to all of us.	Molecular Biology of the Cell	2020
32634419	Organelle Biogenesis: ER Shape Influences Lipid Droplet Nucleation.	Current Biology	2020
30886057	Getting a handle on lipid droplets: Insights into ER-lipid droplet tethering.	Journal of Cell Biology	2019
31634900	The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.	Nature	2019
30523332	Dynamics and functions of lipid droplets.	Nature Reviews Molecular Cell Biology	2019
31285595	Covalent targeting of the vacuolar H<sup>+</sup>-ATPase activates autophagy via mTORC1 inhibition.	Nat Chem Biol	2019
31080076	Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.	Cell Chem Biol	2019
30686757	Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State.	Cell Chem Biol	2019
31124088	Identification of Lipid Droplet Proteomes by Proximity Labeling Proteomics Using APEX2.	Methods in Molecular Biology	2019
31265808	A Tense Situation: Maintaining ER Homeostasis during Lipid Droplet Budding.	Developmental Cell	2019
31209351	Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.	Nat Chem Biol	2019
29275994	A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes.	Dev Cell	2018
30352174	A Proteomic Map to Navigate Subcellular Reorganization in Fatty Liver Disease.	Developmental Cell	2018
30101213	In Close Proximity: The Lipid Droplet Proteome and Crosstalk With the Endoplasmic Reticulum.		2018
29514927	A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates.	Molecular Biology of the Cell	2018
27881664	Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.	Mol Biol Cell	2017
28806138	Lipid droplets and lipotoxicity during autophagy.		2017
28892616	Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity.	ACS Chem Biol	2017
28627435	Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation.	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids	2017
28411238	Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.	J Biol Chem	2017
28697336	DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.	Dev Cell	2017
28352901	Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.	Chem Commun (Camb)	2017
27296502	Endoplasmic Reticulum-Associated Degradation and Lipid Homeostasis.	Annual Review of Nutrition	2016
25612006	A polyubiquitin chain reaction: parkin recruitment to damaged mitochondria.	PLoS Genetics	2015
23297223	Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.	Proceedings of the National Academy of Sciences of the United States of America	2013
23232094	The mammalian endoplasmic reticulum-associated degradation system.	Cold Spring Harbor perspectives in biology	2013
23037595	Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD.	Nature Structural and Molecular Biology	2012
23097496	Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate.	Molecular Biology of the Cell	2012
21693705	Lipid droplet formation is dispensable for endoplasmic reticulum-associated degradation.	Journal of Biological Chemistry	2011