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Author Details

Helena Reijonen
City of Hope Medical Center, Beckman Research Institute
1973
89
38
PMIDPaper TitleJournal TitlePublished Year
37474341Technical Validation and Utility of an HLA Class II Tetramer Assay for Type 1 Diabetes: A Multicenter Study.J Clin Endocrinol Metab2023
34111827Factors related to recycling plastic packaging in Finland's new waste management scheme.Waste Manag2021
32060144Increased islet antigen-specific regulatory and effector CD4<sup>+</sup> T cells in healthy individuals with the type 1 diabetes-protective haplotype.Sci Immunol2020
30626607Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes.Diabetes2019
31147954Production of Antigen-Specific Human CD4<sup>+</sup> T Cell Lines and Clones.Methods Mol Biol2019
28566371Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4<sup>+</sup> T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.J Immunol2017
28081180PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells.PLoS One2017
26317167Risk Factors for Type 1 Diabetes Recurrence in Immunosuppressed Recipients of Simultaneous Pancreas-Kidney Transplants.Am J Transplant2016
26547222Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity.Curr Diab Rep2015
25142715New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation.Curr Diab Rep2014
23329513Production of primary human CD4⁺ T cell lines and clones.Methods Mol Biol2013
21945395Ultra-sensitive detection of rare T cell clones.J Immunol Methods2012
22312112Self-reactive human CD4 T cell clones form unusual immunological synapses.J Exp Med2012
22270037Autoantigen-specific memory CD4+ T cells are prevalent early in progression to Type 1 diabetes.Cell Immunol2012
21257290Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes.J Autoimmun2011
21790295Development of diabetes mellitus in living pancreas donors and recipients.Expert Rev Clin Immunol2011
21927622Recurrence of autoimmunity in pancreas transplant patients: research update.Diabetes Manag (Lond)2011
21660419Recurrence of autoimmunity following pancreas transplantation.Curr Diab Rep2011
20086230Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells.Diabetes2010
20503259Characterization of CD4+ T cells specific for glutamic acid decarboxylase (GAD65) and proinsulin in a patient with stiff-person syndrome but without type 1 diabetes.Diabetes Metab Res Rev2010
20228832Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse.Cell Mol Immunol2010
20370569A low antigen dose selectively promotes expansion of high-avidity autoreactive T cells with distinct phenotypic characteristics: a study of human autoreactive CD4+T cells specific for GAD65.Autoimmunity2010
19931408Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy.J Autoimmun2010
19675135Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.Diabetes2009
18696047Insulin protein and proliferation in ductal cells in the transplanted pancreas of patients with type 1 diabetes and recurrence of autoimmunity.Diabetologia2008
16493034Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects.J Immunol2006
16030184Functional avidity directs T-cell fate in autoreactive CD4+ T cells.Blood2005
16263242GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects.J Autoimmun2005
15047612Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells.Diabetes2004
15549775Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells.Eur J Immunol2004
15277377GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes.Diabetes2004
12480558Polycystic liver disease is genetically heterogeneous: clinical and linkage studies in eight Finnish families.J Hepatol2003
14679042Detection of CD4+ autoreactive T cells in T1D using HLA class II tetramers.Ann N Y Acad Sci2003
12731068Low-avidity recognition by CD4+ T cells directed to self-antigens.Eur J Immunol2003
12725793Use of HLA class II tetramers in tracking antigen-specific T cells and mapping T-cell epitopes.Methods2003
12788873Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children.J Clin Endocrinol Metab2003
11817608HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.Arthritis Rheum2002
12170258Defining antigen-specific responses with human MHC class II tetramers.J Allergy Clin Immunol2002
11978633Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects.Diabetes2002
11777553HLA class II associated risk and protection against multiple sclerosis-a Finnish family study.J Neuroimmunol2002
10615949Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group.Diabetes2000
10866042Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group.Diabetes2000
10998087Geographical differences within Finland in the frequency of HLA-DQ genotypes associated with type 1 diabetes susceptibility. The Childhood Diabetes in Finland Study Group.Eur J Immunogenet2000
11016444GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65.Diabetes2000
10720050Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group.J Clin Endocrinol Metab2000
10587824Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group.Diabetes Care1999
10415074Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals.J Immunol1999
10426279Peptide binding affinity and pH variation establish functional thresholds for activation of HLA-DQ-restricted T cell recognition.Hum Immunol1999
11475299Radioimmunoassay for glutamic acid decarboxylase-65.Diabetes Technol Ther1999
10209508Disease-associated autoantibodies and HLA-DQB1 genotypes in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). The Childhood Diabetes in Finland Study Group.Clin Exp Immunol1999
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Collaborators

Gerald T Nepom
Wash Benaroya Research Institute at Virginia Mason
Co-authored papers 21
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Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
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Phillip Ruiz
Co-authored papers 4
Carla J Greenbaum
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 3
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Benaroya Research Institute
Co-authored papers 3
Jane H Buckner
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 2
Seppo Koskinen
Co-authored papers 2
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Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 2
Karen Cerosaletti
Center for Translational Immunology
Co-authored papers 2
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Shari Messinger
University of Miami Miller School of Medicine
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Kjersti S R??nningen
Oslo University Hospital
Co-authored papers 2
Erik Wambre
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
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Tomi Pastinen
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Fariba Barahmand-Pour
Benaroya Research Institute at Virginia Mason
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Elisabeth Israelsson
Benaroya Research Institute at Virginia Mason
Co-authored papers 1
Matthew J Dufort
Center for Systems Immunology, Benaroya Research Institute Seattle
Co-authored papers 1
James A Eddy
Benaroya Research Institute at Virginia Mason, Institute for Systems Biology, Sage Bionetworks, University of Illinois at Urbana-Champaign
Co-authored papers 1
Raphael Gottardo
Fred Hutchinson Cancer Center
Co-authored papers 1
Sara A Murray
Novo Nordisk Research Center Seattle
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Rafa?? P??oski
Medical University of Warsaw
Co-authored papers 1
Martin Prlic
Fred Hutchinson Cancer Research Center
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Christopher S Carlson
University of Washington
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Jaakko Tuomilehto
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Catherine Pihoker
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Sarah Alice Long
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Release 1.2