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Author Details

Natalia Jura
Cardiovascular Research Institute, University of California San Francisco
2003
67
30
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37577651Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase domain.bioRxiv2024
37336883Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3.Nat Commun2023
37577529Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma.Res Sq2023
35108525Targetable HER3 functions driving tumorigenic signaling in HER2-amplified cancers.Cell Rep2022
35504891CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids.Nat Commun2022
35525557An effective strategy for ligand-mediated pulldown of the HER2/HER3/NRG1β heterocomplex and cryo-EM structure determination at low sample concentrations.Methods Enzymol2022
35525556Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3.Methods Enzymol2022
36070686Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling.Cell Rep2022
36332608Trapping Tribbles: Nanobody-assisted structure of the TRIB2 pseudokinase.Structure2022
35192418Piquing our interest: Insights into the role of PEAK3 in signaling and disease.Sci Signal2022
35132240Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.Nature2022
34942634Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35332335Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2.Nature2022
35108526Extensive conformational and physical plasticity protects HER2-HER3 tumorigenic signaling.Cell Rep2022
33115654Expression and purification of active human kinases using Pichia pastoris as a general-purpose host.Protein Expr Purif2021
33853786Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.Sci Adv2021
33846513Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.Commun Biol2021
33509943Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers.Cancer Res2021
33860789State of the structure address on MET receptor activation by HGF.Biochem Soc Trans2021
34759323Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface.Nature2021
34467245Mutant HER2 needs mutant HER3 to be an effective oncogene.Cell Rep Med2021
34400635Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization.Nat Commun2021
34779417Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.J Clin Invest2021
34591642A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.Science2021
34127972Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant.bioRxiv2021
34013269CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.bioRxiv2021
34031651CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes.Res Sq2021
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
33060197Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.Science2020
33046906The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia.Nat Struct Mol Biol2020
32114309Receptor tyrosine kinase activation: From the ligand perspective.Curr Opin Cell Biol2020
29079424Feedback regulation of RTK signaling in development.Dev Biol2019
31311869PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.Proc Natl Acad Sci U S A2019
31341017The crystal structure of the protein kinase HIPK2 reveals a unique architecture of its CMGC-insert region.J Biol Chem2019
31046201More than the sum of the parts: Toward full-length receptor tyrosine kinase structures.IUBMB Life2019
30705304Functional role of PGAM5 multimeric assemblies and their polymerization into filaments.Nat Commun2019
30850748Prospects for pharmacological targeting of pseudokinases.Nat Rev Drug Discov2019
30390071Overexpression-mediated activation of MET in the Golgi promotes HER3/ERBB3 phosphorylation.Oncogene2019
30692133The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.EMBO J2019
29514089Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.Cell Rep2018
29963236Activating HER3 mutations in breast cancer.Oncotarget2018
30449325Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.Cancer Cell2018
29358026Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.Structure2018
28732202Retraction Notice to: An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase.Cell Chem Biol2017
28320942EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms.Proc Natl Acad Sci U S A2017
28978404Switching on BTK-One Domain at a Time.Structure2017
26745528Structural Basis for the Non-catalytic Functions of Protein Kinases.Structure2016
26124280Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.Mol Cell Biol2015
26643845Src defines a new pool of EGFR substrates.Nat Struct Mol Biol2015
24107129A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.Biochem J2014
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Collaborators

Kliment A Verba
University of California, University of California San Francisco
Co-authored papers 13
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 11
Raphael Trenker
Cardiovascular Research Institute, University of California San Francisco
Co-authored papers 11
Danielle L Swaney
J. David Gladstone Institutes
Co-authored papers 9
Mehdi Bouhaddou
J. David Gladstone Institutes
Co-authored papers 8
Kevan M Shokat
University of California San Francisco
Co-authored papers 7
Megan Lo
University of San Diego
Co-authored papers 7
James S Fraser
University of California san francisco
Co-authored papers 7
David A Agard
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 6
Mark M Moasser
Helen Diller Family Comprehensive Cancer Center
Co-authored papers 6
Margaret Soucheray
J. David Gladstone Institutes
Co-authored papers 6
Kirsten Obernier (CM4AI)
University of California San Francisco
Co-authored papers 6
Hannes Braberg
University of California San Francisco
Co-authored papers 5
Pedro Beltrao
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 5
Lorena Zuliani-Alvarez
J. David Gladstone Institutes
Co-authored papers 5
Joseph B Hiatt
Fred Hutchinson Cancer Center
Co-authored papers 5
Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Gwendolyn M Jang
Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes
Co-authored papers 5
John Kuriyan
University of California berkeley
Co-authored papers 5
Adrian Pelin
University of Ottawa
Co-authored papers 5
Jyoti Batra
J. David Gladstone Institutes
Co-authored papers 5
Jennifer E Kung
Cardiovascular Research Institute, University of California San Francisco
Co-authored papers 5
Danish Memon
European Bioinformatics Institute
Co-authored papers 5
Edmond M Linossi
The Walter and Eliza Hall Institute of Medical Research
Co-authored papers 5
Gregory E Merz
University of California san francisco
Co-authored papers 4
Adam Frost
University of California San Francisco
Co-authored papers 4
Feng Wang
University of California san francisco
Co-authored papers 4
David E Shaw
Columbia University
Co-authored papers 4
Tristan W Owens
University of California san francisco
Co-authored papers 4
Nadia Herrera
University of California san francisco
Co-authored papers 4
Release 1.2