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Author Details

Stephen Y Chan
and Blood Vascular Medicine Institute, University of Pittsburgh School of Medicine
1999
128
43
PMIDPaper TitleJournal TitlePublished Year
36087794Metabolomic Profiles Differentiate Scleroderma-PAH From Idiopathic PAH and Correspond With Worsened Functional Capacity.Chest2023
37478403Innovations in RNA therapy for hemophilia.Blood2023
36974749Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension.J Am Heart Assoc2023
36685041A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3.iScience2023
36775986Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases.J Extracell Vesicles2023
36628260Second International Pulmonary Hypertension/Heart Failure Symposium-Structural heart disease, right ventricular dysfunction, and stem cell therapy: The European Pediatric Pulmonary Vascular Disease Network.Pulm Circ2023
36201758miR-roring Changes in Blood: miR-210 Reflects Hypoxic Disease Dynamics in Obstructive Sleep Apnea.Am J Respir Crit Care Med2023
34528097Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension.Cardiovasc Res2022
35732465Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension.Life Sci Alliance2022
35795496Improved hospitalization rates in a specialty center for heart failure with preserved ejection fraction and pulmonary hypertension.Pulm Circ2022
35575096Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.J Clin Invest2022
35465051miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence.iScience2022
35427414Defenestrated endothelium delays liver-directed gene transfer in hemophilia A mice.Blood Adv2022
35634304VEGF Receptor 1 Promotes Hypoxia-Induced Hematopoietic Progenitor Proliferation and Differentiation.Front Immunol2022
37117763Post-GWAS functional analysis identifies CUX1 as a regulator of p16<sup>INK4a</sup> and cellular senescence.Nat Aging2022
36875282Pulmonary Arterial Hypertension: Emerging Principles of Precision Medicine across Basic Science to Clinical Practice.Rev Cardiovasc Med2022
36671453Metabolic Maturation Exaggerates Abnormal Calcium Handling in a <i>Lamp2</i> Knockout Human Pluripotent Stem Cell-Derived Cardiomyocyte Model of Danon Disease.Biomolecules2022
36370005Association Between Copayment and Adherence to Medications for Pulmonary Arterial Hypertension.J Am Heart Assoc2022
36176897Association between income and likelihood of right heart catheterization in individuals with pulmonary hypertension: A US claims database analysis.Pulm Circ2022
36273529In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis.J Control Release2022
36034404Pulmonary Vascular Research Institute GoDeep: A meta-registry merging deep phenotyping datafrom international PH reference centers.Pulm Circ2022
36195915Circulating hypoxia-dependent miR-210 is increased in clinical sepsis subtypes: A cohort study.J Transl Med2022
35298304Endothelial Senescence: A New Age in Pulmonary Hypertension.Circ Res2022
33420357Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension.Cell Mol Immunol2021
33599144Increased Mortality in Patients With Preoperative and Persistent Postoperative Pulmonary Hypertension Undergoing Mitral Valve Surgery for Mitral Regurgitation: A Cohort Study.J Am Heart Assoc2021
33905372Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.J Clin Invest2021
33788187Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension.Adv Exp Med Biol2021
33565360Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells.Am J Physiol Lung Cell Mol Physiol2021
33888254NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.J Am Coll Cardiol2021
34583280Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing.Stem Cell Res2021
34157861Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.Circulation2021
34102109Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.Cell Metab2021
34056915Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension.J Am Heart Assoc2021
33223140Ranolazine Improves Right Ventricular Function in Patients With Precapillary Pulmonary Hypertension: Results From a Double-Blind, Randomized, Placebo-Controlled Trial.J Card Fail2021
31577451Activation of the Metabolic Master Regulator PPARγ: A Potential PIOneering Therapy for Pulmonary Arterial Hypertension.Am J Respir Cell Mol Biol2020
33268556Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.Cancer Res2020
33294740SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension.JACC Basic Transl Sci2020
32726562A New "TYK" Tok Era for the Study of Long Noncoding RNAs in Pulmonary Hypertension.Am J Respir Crit Care Med2020
32311291Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction 2019.Am J Respir Crit Care Med2020
32109446Outcomes of Pulmonary Arterial Hypertension Are Improved in a Specialty Care Center.Chest2020
32493166Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension.Circ Res2020
32166015Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension.Pulm Circ2020
32128158Lower DLco% identifies exercise pulmonary hypertension in patients with parenchymal lung disease referred for dyspnea.Pulm Circ2020
31526282NFU1, Iron-Sulfur Biogenesis, and Pulmonary Arterial Hypertension: A (Metabolic) Shift in Our Thinking.Am J Respir Cell Mol Biol2020
30280445The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves.J Intern Med2019
31754458A network-based approach to uncover microRNA-mediated disease comorbidities and potential pathobiological implications.NPJ Syst Biol Appl2019
30113078Evolving systems biology approaches to understanding non-coding RNAs in pulmonary hypertension.J Physiol2019
31420607Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ).Oncogene2019
30773044The Search for Disease-Modifying Therapies in Pulmonary Hypertension.J Cardiovasc Pharmacol Ther2019
31092016Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.Arterioscler Thromb Vasc Biol2019
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Collaborators

Emory University
Co-authored papers 12
Harvard Medical School
Co-authored papers 8
Co-authored papers 7
Boston Children's Hospital
Co-authored papers 7
University of Pittsburgh
Co-authored papers 7
University of Pittsburgh
Co-authored papers 4
Brigham and Women's Hospital and Harvard Medical School
Co-authored papers 4
University of Maryland School of Medicine
Co-authored papers 4
Stanford University
Co-authored papers 4
University of California San Francisco
Co-authored papers 3
Herbert Wertheim College of Medicine
Co-authored papers 3
Yale Cardiovascular Research Center, Yale University School of Medicine
Co-authored papers 3
Georgia Institute of Technology
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Department of Veterans Affairs Clinical Assessment
Co-authored papers 2
Co-authored papers 2
Harvard Medical School
Co-authored papers 2
Co-authored papers 2
Co-authored papers 1
Argonne National Laboratory
Co-authored papers 1
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
Co-authored papers 1
E.O. Lawrence Berkeley National Laboratory
Co-authored papers 1
Lawrence Berkeley National Laboratory
Co-authored papers 1
Oak Ridge National Laboratory
Co-authored papers 1
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Co-authored papers 1
Oak Ridge National Laboratory
Co-authored papers 1
Brookhaven National Laboratory
Co-authored papers 1