Author details

Full Name

Steven L Wagner

Affiliation

ORCID

Career Start Year

1984

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37986905	PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease.		2023
35084109	Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease.	Alzheimers Dement	2022
35966019	Age-Dependent Behavioral and Metabolic Assessment of Knock-in (KI) Mice.	Frontiers in Molecular Neuroscience	2022
36224601	Transcriptomic profiling of sporadic Alzheimer's disease patients.	Mol Brain	2022
33651103	Preclinical validation of a potent Î³-secretase modulator for Alzheimer's disease prevention.	J Exp Med	2021
33981778	Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD.	Mol Ther Methods Clin Dev	2021
33007551	Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators.	Bioorg Med Chem	2020
32432881	Î³-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion.	Langmuir	2020
31958080	The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease.	J Alzheimers Dis	2020
32170138	Amyloid-Î²42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease.	Nature Communications	2020
32936886	Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates.	Journal of Experimental Medicine	2020
33188013	Dedifferentiation and neuronal repression define familial Alzheimer's disease.	Sci Adv	2020
30692199	Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor <i>BIN1</i> does not affect amyloid pathology in an AD mouse model.	J Biol Chem	2019
31042463	APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model.	Cell Rep	2019
29078331	Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.	Proc Natl Acad Sci U S A	2017
28416568	Pharmacological and Toxicological Properties of the Potent Oral <i>Î³</i>-Secretase Modulator BPN-15606.	J Pharmacol Exp Ther	2017
28919280	Soluble Gamma-secretase Modulators Attenuate Alzheimer's Î²-amyloid Pathology and Induce Conformational Changes in Presenilin 1.	eBioMedicine	2017
26642089	Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway.	Nature Neuroscience	2016
27426299	Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme.	Bioorg Med Chem Lett	2016
25903103	Î³-Secretase modulators reduce endogenous amyloid Î²42 levels in human neural progenitor cells without altering neuronal differentiation.	FASEB Journal	2015
25710492	A Î³-secretase inhibitor, but not a Î³-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP.	PLoS One	2015
24401146	Soluble Î³-secretase modulators selectively inhibit the production of the 42-amino acid amyloid Î² peptide variant and augment the production of multiple carboxy-truncated amyloid Î² species.	Biochemistry	2014
25285942	Effect of potent Î³-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers.	JAMA Neurol	2014
25352592	A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of Î³-secretase.	J Biol Chem	2014
25307057	A three-dimensional human neural cell culture model of Alzheimer's disease.	Nature	2014
23902769	Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease Î²-amyloid peptide secretion.	J Biol Chem	2013
22801784	Potential use of Î³-secretase modulators in the treatment of Alzheimer disease.	Arch Neurol	2012
21642424	Loss of cleavage at Î²'-site contributes to apparent increase in Î²-amyloid peptide (AÎ²) secretion by Î²-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.	J Biol Chem	2011
20921220	Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates.	J Biol Chem	2010
20826309	Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.	Neuron	2010
21135249	And four equals one: presenilin takes the gamma-secretase role by itself.	Proceedings of the National Academy of Sciences of the United States of America	2010
19907078	NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.	Journal of Clinical Investigation	2009
19608551	Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.	Human Molecular Genetics	2009
20368182	Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.	Sci Transl Med	2009
18976728	Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.	American Journal of Human Genetics	2008
17209133	Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?	Journal of Medical Genetics	2007
16945923	Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.	J Biol Chem	2006
15670587	Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.	Biochemical Pharmacology	2005
15866891	STIM1, an essential and conserved component of store-operated Ca2+ channel function.	Journal of Cell Biology	2005
15745979	Family-based association between Alzheimer's disease and variants in UBQLN1.	N Engl J Med	2005
14645205	Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.	Hum Mol Genet	2004
15339642	Clearance of Alzheimer's Abeta peptide: the many roads to perdition.	Neuron	2004
15494400	ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety.	Journal of Biological Chemistry	2004
12966032	Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin.	Hum Mol Genet	2003
11709540	Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.	Human Molecular Genetics	2001
11067868	Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway.	Journal of Clinical Investigation	2000
10412057	Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.	Nature Neuroscience	1999
10501466	Reduced cerebrospinal fluid levels of alpha-secretase-cleaved amyloid precursor protein in aged rats: correlation with spatial memory deficits.	Neuroscience	1999
10562291	Modulation of amyloid beta protein precursor processing as a means of retarding progression of Alzheimer's disease.	Journal of Clinical Investigation	1999
9285791	Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.	Hum Mol Genet	1997