Author details

Full Name

Daniel J Rader

Affiliation

ORCID

Career Start Year

1983

Papers

884

H Index

147

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37246069	Germline Exome Sequencing for Men with Testicular Germ Cell Tumor Reveals Coding Defects in Chromosomal Segregation and Protein-targeting Genes.	Eur Urol	2024
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
37599905	Large-scale identification of undiagnosed hepatic steatosis using natural language processing.	EClinicalMedicine	2023
37593415	Phenotypes of undiagnosed adults with actionable <i>OTC</i> and <i>GLA</i> variants.	HGG Adv	2023
36656851	Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort.	PLoS Genet	2023
37076217	Familial Hypercholesterolemia: Challenges for a High-Risk Population: JACC Focus Seminar 1/3.		2023
37137589	Lipoprotein(a) and OxidizedÂ Phospholipids: Partners in Crime or Individual Perpetrators inÂ CardiovascularÂ Disease?		2023
37452595	Editorial: MTTP, hepatic steatosis, and plasma lipids-still more questions than answers. Authors' reply.		2023
36879129	Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial.	Nat Med	2023
36802703	Multiancestry Genome-Wide Association Study of Aortic Stenosis Identifies Multiple Novel Loci in the Million Veteran Program.	Circulation	2023
37308786	Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.	Nat Genet	2023
37248657	A coding variant in the microsomal triglyceride transfer protein reduces both hepatic steatosis and plasma lipids.		2023
37119068	Contemporary Homozygous Familial Hypercholesterolemia in the United States: Insights From the CASCADE FH Registry.	J Am Heart Assoc	2023
36865344	Comparison of the structure-function properties of wild-type human apoA-V and a C-terminal truncation associated with elevated plasma triglycerides.		2023
36473023	Novel therapeutic opportunities for familial lecithin:cholesterol acyltransferase deficiency: promises and challenges.	Current Opinion in Lipidology	2023
36798171	Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies.	bioRxiv	2023
37358849	Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality.	JAMA Netw Open	2023
37165871	Evaluating the Contribution of Cell Type-Specific Alternative Splicing to Variation in Lipid Levels.	Circ Genom Precis Med	2023
37038246	Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study.	Eur Heart J	2023
35065092	A systematic review of the natural history and biomarkers of primary lecithin:cholesterol acyltransferase deficiency.	Journal of Lipid Research	2022
36243606	Guidance for the diagnosis and treatment of hypolipidemia disorders.	Journal of Clinical Lipidology	2022
35654975	A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.	Nat Genet	2022
35835913	Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.	Nat Genet	2022
35648418	Macular Degeneration and CETP Inhibition.	JAMA Cardiology	2022
35580180	Impact of natural selection on global patterns of genetic variation and association with clinical phenotypes at genes involved in SARS-CoV-2 infection.	Proc Natl Acad Sci U S A	2022
36220816	Whole genome sequence analysis of blood lipid levels in >66,000 individuals.	Nat Commun	2022
35818571	Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment.	Mol Ther Methods Clin Dev	2022
35757719	Clinical Significance of Serum Albumin and Implications of FcRn Inhibitor Treatment in IgG-Mediated Autoimmune Disorders.	Frontiers in Immunology	2022
35571674	Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction.		2022
35381375	Specificity of ABCA7-mediated cell lipid efflux.	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids	2022
36285790	Early Midlife Cardiovascular Health Influences Future HDL Metrics in Women: The SWAN HDL Study.	Journal of the American Heart Association	2022
36154123	Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.	Circulation	2022
35999217	Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes.	Nat Commun	2022
35939579	Germline Mutations in <i>CIDEB</i> and Protection against Liver Disease.	N Engl J Med	2022
36138490	RNA-targeted therapeutics in cardiovascular disease: the time is now.	European Heart Journal - Cardiovascular Pharmacotherapy	2022
36067277	Gain-of-Function Variants in Lipid Genes Enhance Biological Insight and Point Toward Therapeutic Opportunities.	Circulation	2022
35927356	Targeting ASGR1 to lower cholesterol.	Nature Metabolism	2022
35927319	Rare genetic variants explain missing heritability in smoking.	Nat Hum Behav	2022
36261003	SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinations.	Cell Rep	2022
35915156	Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.	Nat Med	2022
36513072	Exome-wide association analysis of CT imaging-derived hepatic fat in a medical biobank.	Cell Rep Med	2022
36572909	ApoJ/Clusterin concentrations are determinants of cerebrospinal fluid cholesterol efflux capacity and reduced levels are associated with Alzheimer's disease.	Alzheimers Res Ther	2022
36484966	Contrasting Views of Autism Spectrum Traits in Adults, Especially in Self-Reports vs. Informant-Reports for Women High in Autism Spectrum Traits.		2022
36556195	The Penn Medicine BioBank: Towards a Genomics-Enabled Learning Healthcare System to Accelerate Precision Medicine in a Diverse Population.	J Pers Med	2022
34281439	A Genome-First Approach to Rare Variants in Dominant Postlingual Hearing Loss Genes in a Large Adult Population.	Otolaryngol Head Neck Surg	2022
35298649	Associations of Abdominal and Cardiovascular Adipose Tissue Depots With HDL Metrics in Midlife Women: the SWAN Study.	Journal of Clinical Endocrinology and Metabolism	2022
35040871	Association of Telomere Length With Risk of Disease and Mortality.	JAMA Intern Med	2022
35288522	Dietary Vitamin E Intake Is Associated With a Reduced Risk of Developing Digestive Diseases and Nonalcoholic Fatty Liver Disease.	American Journal of Gastroenterology	2022
35240684	The Relationship Between Lipoproteins and Insulin Sensitivity in Youth With Obesity and Abnormal Glucose Tolerance.	J Clin Endocrinol Metab	2022
34390340	Associations of Endogenous Hormones With HDL Novel Metrics Across the Menopause Transition: The SWAN HDL Study.	Journal of Clinical Endocrinology and Metabolism	2022