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Author Details

Jonathan G Lees
University College London, Institute of Structural and Molecular Biology
2003
57
27
PMIDPaper TitleJournal TitlePublished Year
37787768Broad functional profiling of fission yeast proteins using phenomics and machine learning.Elife2023
36408455Structural and energetic analyses of SARS-CoV-2 <i>N</i>-terminal domain characterise sugar binding pockets and suggest putative impacts of variants on COVID-19 transmission.Comput Struct Biotechnol J2022
33237325CATH: increased structural coverage of functional space.Nucleic Acids Res2021
33651795Biological impact of mutually exclusive exon switching.PLoS Comput Biol2021
34041266Tracing Evolution Through Protein Structures: Nature Captured in a Few Thousand Folds.Front Mol Biosci2021
33020502SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals.Sci Rep2020
33116184Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila.Sci Rep2020
32760087Characterisation of protein isoforms encoded by the Drosophila Glycogen Synthase Kinase 3 gene shaggy.PLoS One2020
30335683Comprehensive analysis of long noncoding RNA expression in dorsal root ganglion reveals cell-type specificity and dysregulation after nerve injury.Pain2019
31744546The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.Genome Biol2019
31083952Comparison of Drosophila melanogaster Embryo and Adult Proteome by SWATH-MS Reveals Differential Regulation of Protein Synthesis, Degradation Machinery, and Metabolism Modules.J Proteome Res2019
30295745cath-resolve-hits: a new tool that resolves domain matches suspiciously quickly.Bioinformatics2019
30398663CATH: expanding the horizons of structure-based functional annotations for genome sequences.Nucleic Acids Res2019
30649516Requirement for PRC1 subunit BMI1 in host gene activation by Epstein-Barr virus protein EBNA3C.Nucleic Acids Res2019
29112716Gene3D: Extensive prediction of globular domains in proteins.Nucleic Acids Res2018
29194501Gene3D: Extensive prediction of globular domains in proteins.Nucleic Acids Res2018
27899584CATH: an expanded resource to predict protein function through structure and sequence.Nucleic Acids Res2017
28150234CATH-Gene3D: Generation of the Resource and Its Use in Obtaining Structural and Functional Annotations for Protein Sequences.Methods Mol Biol2017
29045400Analysis of temporal transcription expression profiles reveal links between protein function and developmental stages of Drosophila melanogaster.PLoS Comput Biol2017
28717200Genome-wide RNA-Sequencing analysis identifies a distinct fibrosis gene signature in the conjunctiva after glaucoma surgery.Sci Rep2017
28860623Structural and Functional View of Polypharmacology.Sci Rep2017
27903901Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression.Nucleic Acids Res2017
28054549Corrigendum: Defining functional interactions during biogenesis of epithelial junctions.Nat Commun2017
27088890The Pain in Neuropathy Study (PiNS): a cross-sectional observational study determining the somatosensory phenotype of painful and painless diabetic neuropathy.Pain2016
26578585Gene3D: expanding the utility of domain assignments.Nucleic Acids Res2016
27604469An expanded evaluation of protein function prediction methods shows an improvement in accuracy.Genome Biol2016
27922008Defining functional interactions during biogenesis of epithelial junctions.Nat Commun2016
27477482Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.Bioinformatics2016
27309309Functional innovation from changes in protein domains and their combinations.Curr Opin Struct Biol2016
25348408CATH: comprehensive structural and functional annotations for genome sequences.Nucleic Acids Res2015
26275604Identifying and characterising key alternative splicing events in Drosophila development.BMC Genomics2015
26288239Gene Function Prediction from Functional Association Networks Using Kernel Partial Least Squares Regression.PLoS One2015
26139634Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.Bioinformatics2015
25964299CATH FunFHMMer web server: protein functional annotations using functional family assignments.Nucleic Acids Res2015
25667547FUN-L: gene prioritization for RNAi screens.Bioinformatics2015
24270792Gene3D: Multi-domain annotations for protein sequence and comparative genome analysis.Nucleic Acids Res2014
24943848Integration of biological data by kernels on graph nodes allows prediction of new genes involved in mitotic chromosome condensation.Mol Biol Cell2014
23059966Systems biology approaches to finding novel pain mediators.Wiley Interdiscip Rev Syst Biol Med2013
24036287PainNetworks: a web-based resource for the visualisation of pain-related genes in the context of their network associations.Pain2013
23203873New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures.Nucleic Acids Res2013
22139938Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis.Nucleic Acids Res2012
22427808Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology.PLoS One2012
21646335The Gene3D Web Services: a platform for identifying, annotating and comparing structural domains in protein sequences.Nucleic Acids Res2011
21572181Systematic computational prediction of protein interaction networks.Phys Biol2011
19906693Gene3D: merging structure and function for a Thousand genomes.Nucleic Acids Res2010
20851221Assessment of protein domain fusions in human protein interaction networks prediction: application to the human kinetochore model.N Biotechnol2010
20947012Transient protein-protein interactions: structural, functional, and network properties.Structure2010
20885791Finding the "dark matter" in human and yeast protein network prediction and modelling.PLoS Comput Biol2010
19614587The evolution of protein functions and networks: a family-centric approach.Biochem Soc Trans2009
18197968Combining sequence-based prediction methods and circular dichroism and infrared spectroscopic data to improve protein secondary structure determinations.BMC Bioinformatics2008
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Collaborators

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Natalie L Dawson
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Corin Yeats
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University College London
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Kathryn S Lilley
University of Cambridge
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Neeladri Sen
Institute of Structural and Molecular Biology, University College London
Co-authored papers 2
Burkhard Rost
Technical University of Munich (TUM)
Co-authored papers 2
Jan Ellenberg
Institute of Child Health and Human Development
Co-authored papers 2
Alfredo Benso
Italy Consorzio Interuniversitario Nazionale per l'Informatica
Co-authored papers 2
Giuseppe Profiti
University of Bologna
Co-authored papers 2
Federico Minneci
University College London
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Kai Hakala
University of Turku
Co-authored papers 2
Christophe Dessimoz
University of Lausanne
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Domenico Cozzetto
Imperial College London
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Maria J Martin
European Bioinformatics Institute (EMBL-EBI)
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