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Author Details

Alexander Drilon
Memorial Sloan Kettering Cancer Center
2008
215
67
PMIDPaper TitleJournal TitlePublished Year
37838086Microsatellite Instability and Mismatch Repair Deficiency Define a Distinct Subset of Lung Cancers Characterized by Smoking Exposure, High Tumor Mutational Burden, and Recurrent Somatic MLH1 Inactivation.J Thorac Oncol2024
37796533Decision-making as discovery: Vetting clinical research in a leading precision oncology service.Sociol Health Illn2024
37849038Quantifying the Expanding Landscape of Clinical Actionability for Patients with Cancer.Cancer Discov2024
36122315Selpercatinib in Patients With RET Fusion-Positive Non-Small-Cell Lung Cancer: Updated Safety and Efficacy From the Registrational LIBRETTO-001 Phase I/II Trial.J Clin Oncol2023
38084089Precision Oncology: 2023 in Review.Cancer Discov2023
37627175<i>RET</i>-Altered Cancers-A Tumor-Agnostic Review of Biology, Diagnosis and Targeted Therapy Activity.Cancers (Basel)2023
37972337Amplification of Wild-Type <i>RET</i> Represents a Novel Molecular Subtype of Several Cancer Types With Clinical Response to Selpercatinib.JCO Precis Oncol2023
37769225Important Considerations for Real-World Analysis of Neurotrophic Tyrosine Receptor Kinase Fusion Cancer and Tropomyosin Receptor Kinase Inhibitors.JCO Precis Oncol2023
37769113Larotrectinib efficacy and safety in adult patients with tropomyosin receptor kinase fusion sarcomas.Cancer2023
37087124In Reply to "Selpercatinib Controls Central Nervous System Disease in Patients With RET Fusion-Positive NSCLC".J Thorac Oncol2023
37451181A demand-offer critical analysis of current drug development. Phase I drugs versus TCGA sequencing data.Eur J Cancer2023
37182602Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification.J Thorac Oncol2023
37274265Case Report: Complete pathologic response to neoadjuvant selpercatinib in a patient with resectable early-stage <i>RET</i> fusion-positive non-small cell lung cancer.Front Oncol2023
37269335SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.Cancer Discov2023
37262390Response to Repotrectinib After Development of <i>NTRK</i> Resistance Mutations on First- and Second-Generation TRK Inhibitors.JCO Precis Oncol2023
36996726Organizing precision medicine: A case study of Memorial Sloan Kettering Cancer Center's engagement in/with genomics.Soc Sci Med2023
36996322Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers.Clin Cancer Res2023
36780766Characterization of Central Nervous System Clinico-Genomic Outcomes in ALK-Positive Non-Small Cell Lung Cancer Patients with Brain Metastases Treated with Alectinib.Lung Cancer2023
36610231Precision oncology using organoids of a secretory carcinoma of the salivary gland treated with TRK-inhibitors.Oral Oncol2023
36511802NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations.Cancer Discov2023
36806787Rare molecular subtypes of lung cancer.Nat Rev Clin Oncol2023
36682841Response to Provenzano et al. and De Carlo et al.J Thorac Oncol2023
36907745Trends in location of death for individuals with metastatic lung cancer in the United States.Am J Surg2023
36657661Central Nervous System Disease in Patients With RET Fusion-Positive NSCLC Treated With Selpercatinib.J Thorac Oncol2023
34480094NTRK1 Fusions identified by non-invasive plasma next-generation sequencing (NGS) across 9 cancer types.Br J Cancer2022
35383193Author Correction: The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.Nat Commun2022
35476549ALK Inhibitors in Patients With ALK Fusion-Positive GI Cancers: An International Data Set and a Molecular Case Series.JCO Precis Oncol2022
35705558Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.Nat Commun2022
35704797Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase.JCO Precis Oncol2022
35672677Rationale and design of ON-TRK: a novel prospective non-interventional study in patients with TRK fusion cancer treated with larotrectinib.BMC Cancer2022
35536733Larotrectinib Treatment for Patients With TRK Fusion-Positive Salivary Gland Cancers.Oncologist2022
35430374Clinical Utility and Performance of an Ultrarapid Multiplex RNA-Based Assay for Detection of ALK, ROS1, RET, and NTRK1/2/3 Rearrangements and MET Exon 14 Skipping Alterations.J Mol Diagn2022
35394532An Ascendant Challenge: Central Nervous System Metastases in ALK+ Lung Cancers.Clin Cancer Res2022
35788405Brief Report: Chylothorax and Chylous Ascites During RET Tyrosine Kinase Inhibitor Therapy.J Thorac Oncol2022
35663414Long-Term Efficacy and Safety of Entrectinib in <i>ROS1</i> Fusion-Positive NSCLC.JTO Clin Res Rep2022
35484264Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.Nat Med2022
35553647Correction: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients with NTRK Fusion-Positive Solid Tumors.Clin Cancer Res2022
36606522Testing methods to diagnose TRK fusion cancer - a plain language summary and patient perspective.Future Oncol2022
36458431Precision Oncology: 2022 in Review.Cancer Discov2022
36418296Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies.Nat Commun2022
36108661Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1/2, open-label, basket trial.Lancet Oncol2022
36108503Refining patient selection of MET-activated non-small cell lung cancer through biomarker precision.Cancer Treat Rev2022
36044468Bioinformatically Expanded Next-Generation Sequencing Analysis Optimizes Identification of Therapeutically Relevant MET Copy Number Alterations in &gt;50,000 Tumors.Clin Cancer Res2022
36357680Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer.Nat Med2022
36201714Outcomes With Local Therapy and Tyrosine Kinase Inhibition in Patients With <i>ALK</i>/<i>ROS1</i>/<i>RET</i>-Rearranged Lung Cancers.JCO Precis Oncol2022
35950566LIBRETTO-432, a phase III study of adjuvant selpercatinib or placebo in stage IB-IIIA <i>RET</i> fusion-positive non-small-cell lung cancer.Future Oncol2022
35947247Phase I study of lurbinectedin in combination with weekly paclitaxel with or without bevacizumab in patients with advanced solid tumors.Invest New Drugs2022
35183775Hypersensitivity Reactions to Selpercatinib Treatment With or Without Prior Immune Checkpoint Inhibitor Therapy in Patients With NSCLC in LIBRETTO-001.J Thorac Oncol2022
35183043Correlation between treatment effects on response rate and progression-free survival and overall survival in trials of targeted therapies in molecularly enriched populations.ESMO Open2022
35149545MYC Promotes Tyrosine Kinase Inhibitor Resistance in ROS1-Fusion-Positive Lung Cancer.Mol Cancer Res2022
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Collaborators

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Co-authored papers 58
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Co-authored papers 30
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Co-authored papers 30
Co-authored papers 22
Peter MacCallum Cancer Centre
Co-authored papers 10
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Co-authored papers 9
Oregon Health Sciences University
Co-authored papers 8
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Co-authored papers 8
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Co-authored papers 8
Memorial Sloan Kettering Cancer Center
Co-authored papers 7
Co-authored papers 6
Memorial Sloan Kettering Cancer Center
Co-authored papers 6
Memorial Sloan-Kettering Cancer Center
Co-authored papers 5
Peter MacCallum Cancer Centre
Co-authored papers 5
Memorial Sloan Kettering Cancer Center
Co-authored papers 5
University of Texas MD Anderson Cancer Center
Co-authored papers 5
Memorial Sloan Kettering Cancer Center
Co-authored papers 5
Memorial Sloan Kettering Cancer Center
Co-authored papers 5
Co-authored papers 5
Co-authored papers 4
Injury Prevention Research Center, University of North Carolina
Co-authored papers 4
UCSF Helen Diller Comprehensive Cancer Center
Co-authored papers 4
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
David Geffen School of Medicine at university of california los angeles
Co-authored papers 4
Memorial Sloan Kettering Cancer Center
Co-authored papers 4
Samsung Medical Center, Sungkyunkwan University School of Medicine
Co-authored papers 3
Massachusetts General Hospital
Co-authored papers 3
Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Foundation Medicine
Co-authored papers 3