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Author Details

David de Graaf
Syntimmune Inc.
1995
21
15
Dexter Pratt (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
31897428Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.Sci Adv2019
26036272Blood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis.BMC Med Genomics2015
23769977A decade of Systems Biology: where are we and where are we going to?Drug Discov Today2014
23872468Systems diagnostics: anticipating the next generation of diagnostic tests based on mechanistic insight into disease.Drug Discov Today2014
24205542Multi-omic biomarkers unlock the potential of diagnostic testing.MLO Med Lab Obs2013
22155224A network-based approach to quantifying the impact of biologically active substances.Drug Discov Today2012
29768793Company Profile: Selventa, Inc.Per Med2012
22161357Early patient stratification and predictive biomarkers in drug discovery and development: a case study of ulcerative colitis anti-TNF therapy.Adv Exp Med Biol2012
21904331Verification of systems biology research in the age of collaborative competition.Nat Biotechnol2011
20617251Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line.Mol Biosyst2010
18282474Multiple effects of acetaminophen and p38 inhibitors: towards pathway toxicology.FEBS Lett2008
18524759Cellular imaging predictions of clinical drug-induced liver injury.Toxicol Sci2008
17672894A protein interaction atlas for the nuclear receptors: properties and quality of a hub-based dimerisation network.BMC Syst Biol2007
16983832Computational modelling of ErbB family phosphorylation dynamics in response to transforming growth factor alpha and heregulin indicates spatial compartmentation of phosphatase activity.Syst Biol (Stevenage)2006
17186707Decreased internalisation of erbB1 mutants in lung cancer is linked with a mechanism conferring sensitivity to gefitinib.Syst Biol (Stevenage)2006
16935748Applying computational modeling to drug discovery and development.Drug Discov Today2006
12438646Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells.Proc Natl Acad Sci U S A2002
9711557Isolation of altered-function mutants and genetic suppressor elements of multidrug transporter P-glycoprotein by expression selection from retroviral libraries.Methods Enzymol1998
8577747P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake.Proc Natl Acad Sci U S A1996
8598312Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate.Int J Cancer1996
7819214Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators.Biochemistry1995
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Collaborators

Douglas A Lauffenburger
Massachusetts Institute of Technology
Co-authored papers 4
Manuel C Peitsch
Philip Morris International Research Laboratories Pte. Ltd
Co-authored papers 3
David A Drubin
Harvard Medical School
Co-authored papers 3
Renee Deehan
University of California berkeley
Co-authored papers 3
Julia Hoeng
Vectura Fertin Pharma
Co-authored papers 2
Ty M Thomson
FOG Pharmaceuticals Inc.
Co-authored papers 2
Erich Bornberg-Bauer
Institute for Evolution and Biodiversity, University of Munster
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Kevin A Janes
University of Virginia
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Marc Robinson-Rechavi
University of Lausanne
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Rune Linding
Humboldt-Universitat zu Berlin
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Stephen G Oliver
University of Cambridge
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Arnold J Levine
Simons Center for Systems Biology, Institute for Advanced Study
Co-authored papers 1
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IBM T.J. Watson Research Center
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Christina A Waters
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UC San Diego
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Alain Sewer
Universitat Basel
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Natalie L Catlett
Torrey Mesa Research Institute/Syngenta Research and Technology
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Florian Martin
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Andrea Califano
Columbia University
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Daniel Marbach
Roche Pharma Research and Early Development
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Todd R Golub
Broad Institute of MIT and Harvard
Co-authored papers 1
Elgar Pichler
Northeastern University
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Eric S Lander
Vanderbilt-Ingram Cancer Center, Vanderbilt University
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Berthold Göttgens
Co-authored papers 1
John J Rice
Co-authored papers 1
Raquel Norel
IBM T.J. Watson Research Center
Co-authored papers 1
Peter K Sorger
Co-authored papers 1
Stefano Monti
Co-authored papers 1
Michelle Haber
School of Clinical Medicine
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Release 1.2