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Author Details

Howard J Jacob
Genomics Research Center
1986
282
68
PMIDPaper TitleJournal TitlePublished Year
36829046Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population.Nature2023
36653562FinnGen provides genetic insights from a well-phenotyped isolated population.Nature2023
35365203The landscape of GWAS validation; systematic review identifying 309 validated non-coding variants across 130 human diseases.BMC Med Genomics2022
34504346Toward best practice in cancer mutation detection with whole-genome and whole-exome sequencing.Nat Biotechnol2021
34504347Establishing community reference samples, data and call sets for benchmarking cancer mutation detection using whole-genome sequencing.Nat Biotechnol2021
32029431A Mutation in <i>γ</i>-Adducin Impairs Autoregulation of Renal Blood Flow and Promotes the Development of Kidney Disease.J Am Soc Nephrol2020
30540547Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics.Physiol Genomics2019
29460415Research Directions in the Clinical Implementation of Pharmacogenomics: An Overview of US Programs and Projects.Clin Pharmacol Ther2018
30304647Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.N Engl J Med2018
29476007Characterization of Coding/Noncoding Variants for <i>SHROOM3</i> in Patients with CKD.J Am Soc Nephrol2018
28931751Essential role of Kir5.1 channels in renal salt handling and blood pressure control.JCI Insight2017
28340351Bedside Back to Bench: Building Bridges between Basic and Clinical Genomic Research.Cell2017
28496993Successful Application of Whole Genome Sequencing in a Medical Genetics Clinic.J Pediatr Genet2017
28204942Molecular modeling in the age of clinical genomics, the enterprise of the next generation.J Mol Model2017
26810587Toward clinical genomics in everyday medicine: perspectives and recommendations.Expert Rev Mol Diagn2016
26631737Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.Diabetes2016
26534937Pappa2 is linked to salt-sensitive hypertension in Dahl S rats.Physiol Genomics2016
27736743From rat pathophysiology to genomic medicine: an interview with Howard Jacob.Dis Model Mech2016
27270176p66Shc regulates renal vascular tone in hypertension-induced nephropathy.J Clin Invest2016
26990947Rat Blastocysts from Nuclear Injection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells.Cell Reprogram2016
26848384The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains.Biol Sex Differ2016
25149474Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome.Hum Mol Genet2015
26063669B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension.Hypertension2015
26108065Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.Kidney Int2015
25915538Plasma genetic and genomic abnormalities predict treatment response and clinical outcome in advanced prostate cancer.Oncotarget2015
25628389SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.Circ Cardiovasc Genet2015
25776069Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.Hypertension2015
25540098Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.Am J Physiol Regul Integr Comp Physiol2015
25260253Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system.Gen Comp Endocrinol2015
25273069Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity.Genome Res2015
25217576Improved rat genome gene prediction by integration of ESTs with RNA-Seq information.Bioinformatics2015
25355511The Rat Genome Database 2015: genomic, phenotypic and environmental variations and disease.Nucleic Acids Res2015
24499703The pathway ontology - updates and applications.J Biomed Semantics2014
25265995Disease pathways at the Rat Genome Database Pathway Portal: genes in context-a network approach to understanding the molecular mechanisms of disease.Hum Genomics2014
25236446Identification of a novel gene for diabetic traits in rats, mice, and humans.Genetics2014
25320330Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12.Am J Physiol Heart Circ Physiol2014
25397684Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats.PLoS One2014
25001272Refined mapping of a hypertension susceptibility locus on rat chromosome 12.Hypertension2014
25172839CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.Cancer Res2014
25136115Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat.Proc Natl Acad Sci U S A2014
24935944HV1 acts as a sodium sensor and promotes superoxide production in medullary thick ascending limb of Dahl salt-sensitive rats.Hypertension2014
24714719Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.Physiol Genomics2014
24627900Genetic diagnosis through whole-exome sequencing.N Engl J Med2014
24343121CD247 modulates blood pressure by altering T-lymphocyte infiltration in the kidney.Hypertension2014
24322611Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase.Am J Physiol Heart Circ Physiol2014
23144316Identification of a region of rat chromosome 1 that impairs the myogenic response and autoregulation of cerebral blood flow in fawn-hooded hypertensive rats.Am J Physiol Heart Circ Physiol2013
24088040Next-generation sequencing for clinical diagnostics.N Engl J Med2013
24267899Rat Strain Ontology: structured controlled vocabulary designed to facilitate access to strain data at RGD.J Biomed Semantics2013
23890820Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.Cell2013
23881287Rat Genome Database: a unique resource for rat, human, and mouse quantitative trait locus data.Physiol Genomics2013
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Collaborators

Medical College of Wisconsin
Co-authored papers 42
Co-authored papers 29
Co-authored papers 24
Medical College of Wisconsin
Co-authored papers 23
Medical College of Wisconsin
Co-authored papers 23
Heersink School of Medicine, The University of Alabama at Birmingham
Co-authored papers 18
University of Missouri School of Medicine
Co-authored papers 17
Vanderbilt-Ingram Cancer Center, Vanderbilt University
Co-authored papers 17
Medical College of Wisconsin and Marquette University
Co-authored papers 17
Medical College of Wisconsin
Co-authored papers 12
Medical College of Wisconsin
Co-authored papers 12
National Academy of Medicine.
Co-authored papers 12
Medical College of Wisconsin
Co-authored papers 11
Medical College of Wisconsin
Co-authored papers 11
Medical College of Wisconsin
Co-authored papers 11
Medical College of Wisconsin
Co-authored papers 10
Medical College of Wisconsin
Co-authored papers 10
Co-authored papers 8
University of California San Diego
Co-authored papers 7
Medical College of Wisconsin
Co-authored papers 7
Co-authored papers 7
Montreal University Hospital Research Center
Co-authored papers 7
Co-authored papers 7
Max Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC)
Co-authored papers 6
Rady Children's Institute for Genomic Medicine
Co-authored papers 5
Texas Biomedical Research Institute
Co-authored papers 4
H. Lee Moffitt Cancer Center
Co-authored papers 4
Massachusetts General Hospital
Co-authored papers 4
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