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Author Details

Lawrence A Donehower
Baylor College of Medicine
1975
200
69
PMIDPaper TitleJournal TitlePublished Year
35301263A general calculus of fitness landscapes finds genes under selection in cancers.Genome Res2022
35412634EPIMUTESTR: a nearest neighbor machine learning approach to predict cancer driver genes from the evolutionary action of coding variants.Nucleic Acids Res2022
35174853K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications.Dis Model Mech2022
33568653A pediatric brain tumor atlas of genes deregulated by somatic genomic rearrangement.Nat Commun2021
31959038WIP1 dephosphorylation of p27<sup>Kip1</sup> Serine 140 destabilizes p27<sup>Kip1</sup> and reverses anti-proliferative effects of ATM phosphorylation.Cell Cycle2020
31365877Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.Cell Rep2019
31509758Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.Cell Rep2019
29047229Enhanced inflammation and attenuated tumor suppressor pathways are associated with oncogene-induced lung tumors in aged mice.Aging Cell2018
30323968Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma.Am J Cancer Res2018
30266789Literature-based automated discovery of tumor suppressor p53 phosphorylation and inhibition by NEK2.Proc Natl Acad Sci U S A2018
30388424PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.Cell Stem Cell2018
29617664Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.Cell Rep2018
29617660Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.Cell Rep2018
28027003LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.Cell Cycle2017
28254861Recommended Guidelines for Validation, Quality Control, and Reporting of <i>TP53</i> Variants in Clinical Practice.Cancer Res2017
28748534miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.Int J Cancer2017
26804919Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation.Cell Rep2016
27821163Secreted Frizzled-Related Protein 2 (sFRP2) promotes osteosarcoma invasion and metastatic potential.BMC Cancer2016
25579177NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.Oncogene2015
26355645Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma.Genes Chromosomes Cancer2015
26528706Loss of Runx2 sensitises osteosarcoma to chemotherapy-induced apoptosis.Br J Cancer2015
26551670Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.Nat Genet2015
26019260Ghrelin Prevents Cisplatin-Induced Testicular Damage by Facilitating Repair of DNA Double Strand Breaks Through Activation of p53 in Mice.Biol Reprod2015
25658463WIP1 phosphatase as a potential therapeutic target in neuroblastoma.PLoS One2015
25784290Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma.Cancer Med2015
24415648Insights into wild-type and mutant p53 functions provided by genetically engineered mice.Hum Mutat2014
25409906Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.Nat Commun2014
25203324Notch activation as a driver of osteogenic sarcoma.Cancer Cell2014
25362482Trans-ancestry mutational landscape of hepatocellular carcinoma genomes.Nat Genet2014
25024203Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.Proc Natl Acad Sci U S A2014
25155756The somatic genomic landscape of chromophobe renal cell carcinoma.Cancer Cell2014
24808140Phosphatases reverse p53-mediated cell cycle checkpoints.Proc Natl Acad Sci U S A2014
24374933Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.J Pathol2014
24463180Combinatorial therapy discovery using mixed integer linear programming.Bioinformatics2014
22899370MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes.J Pathol2013
23766372REGγ deficiency promotes premature aging via the casein kinase 1 pathway.Proc Natl Acad Sci U S A2013
23405243Activation of WIP1 phosphatase by HTLV-1 Tax mitigates the cellular response to DNA damage.PLoS One2013
23564453Transcriptional and translational regulation of C/EBPβ-HDAC1 protein complexes controls different levels of p53, SIRT1, and PGC1α proteins at the early and late stages of liver cancer.J Biol Chem2013
21765465Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.Oncogene2012
23128359Rapamycin as longevity enhancer and cancer preventative agent in the context of p53 deficiency.Aging (Albany NY)2012
22532587Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.Mol Cancer Res2012
21191649P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.Breast Cancer Res Treat2011
21674502Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models.J Pathol2011
21334322Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin.Dev Biol2011
20107151Widespread and tissue specific age-related DNA methylation changes in mice.Genome Res2010
20859824Review of chromium (VI) apoptosis, cell-cycle-arrest, and carcinogenesis.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev2010
2049317455K isoform of CDK9 associates with Ku70 and is involved in DNA repair.Biochem Biophys Res Commun2010
20451471The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.DNA Repair (Amst)2010
20539819Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice.PLoS One2010
20495376Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.Cell Cycle2010
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Collaborators

The Wellcome Trust Sanger Institute
Co-authored papers 25
Baylor College of Medicine
Co-authored papers 10
Baylor College of Medicine
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Baylor College of Medicine
Co-authored papers 5
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Baylor College of Medicine
Co-authored papers 5
Baylor College of Medicine
Co-authored papers 5
The University of Chicago
Co-authored papers 4
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
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Co-authored papers 4
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
National Cancer Institute, National Institutes of Health
Co-authored papers 3
Van Andel Institute
Co-authored papers 3
College of Biology and Food, Shangqiu Normal University
Co-authored papers 3
Dana-Farber Cancer Institute
Co-authored papers 3
Baylor College of Medicine
Co-authored papers 3
Van Andel Institute
Co-authored papers 3
The University of Western Australia
Co-authored papers 3
Baylor College of Medicine
Co-authored papers 3
Baylor College of Medicine
Co-authored papers 3
MD Anderson Cancer Center
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The University of Texas MD Anderson Cancer Center
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University of Texas MD Anderson Cancer Center
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The Hospital for Sick Children
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University of California San Francisco
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Present address: Dxige Research Inc.
Co-authored papers 2