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Author Details

Eloise Hudry
Massachusetts General Hospital/Harvard Medical School
2010
50
28
Timothy Clark (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37236808Neuronally Derived Soluble Abeta Evokes Cell-Wide Astrocytic Calcium Dysregulation in Absence of Amyloid Plaques <i>in Vivo</i>.J Neurosci2023
37515322Liver injury in cynomolgus monkeys following intravenous and intrathecal scAAV9 gene therapy delivery.Mol Ther2023
37547292<i>VWA3A</i>-derived ependyma promoter drives increased therapeutic protein secretion into the CSF.Mol Ther Nucleic Acids2023
37376759An Engineered Adeno-Associated Virus Capsid Mediates Efficient Transduction of Pericytes and Smooth Muscle Cells of the Brain Vasculature.Hum Gene Ther2023
34957486APOE4 derived from astrocytes leads to blood-brain barrier impairment.Brain2022
35658751Intrathecal sc-AAV9-CB-GFP: Systemic Distribution Predominates Following Single-Dose Administration in Cynomolgus Macaques.Toxicol Pathol2022
36700120Neurofilament light chain and dorsal root ganglia injury after adeno-associated virus 9 gene therapy in nonhuman primates.Mol Ther Methods Clin Dev2022
33554064Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation.iScience2021
36199750Effect of <i>APOE</i> alleles on the glial transcriptome in normal aging and Alzheimer's disease.Nat Aging2021
32517777Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice.Mol Neurodegener2020
32803224Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.Hum Mol Genet2020
32358564Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease.Nat Commun2020
30844402Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality.Neuron2019
31788496Selection of an Efficient AAV Vector for Robust CNS Transgene Expression.Mol Ther Methods Clin Dev2019
31249873Experimental evidence for the age dependence of tau protein spread in the brain.Sci Adv2019
31534984Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1.Mol Ther Methods Clin Dev2019
31018141The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.Cell Rep2019
30946822Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality.Neuron2019
30760557Opposing Roles of apolipoprotein E in aging and neurodegeneration.Life Sci Alliance2019
29348604Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis.Sci Rep2018
29806693Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain.J Neurochem2018
30072889<i>In Vivo</i> Two Photon Imaging of Astrocytic Structure and Function in Alzheimer's Disease.Front Aging Neurosci2018
29950521A flow cytometry-based <i>in vitro</i> assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform and cell type.J Biol Chem2018
30109242Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65.Mol Ther Methods Clin Dev2018
29767307Virus vector-mediated genetic modification of brain tumor stromal cells after intravenous delivery.J Neurooncol2018
29600961Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.J Clin Invest2018
26905292Viral vectors for therapy of neurologic diseases.Neuropharmacology2017
28129105New Therapeutic Avenue for ALS: Avoiding a Fatal Encounter of TDP-43 at the Mitochondria.Mol Ther2017
28327181Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain.Mol Neurodegener2017
28744197Neuronal Cholesterol Accumulation Induced by Cyp46a1 Down-Regulation in Mouse Hippocampus Disrupts Brain Lipid Homeostasis.Front Mol Neurosci2017
28684412Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.J Biol Chem2017
27718541Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells.J Neurochem2017
26836117Exosome-associated AAV vector as a robust and convenient neuroscience tool.Gene Ther2016
27933308Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9.Mol Ther Methods Clin Dev2016
27808124Exosome-associated AAV vector as a robust and convenient neuroscience tool.Gene Ther2016
25468905A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease.J Biol Chem2015
26297855Massachusetts Alzheimer's Disease Research Center: progress and challenges.Alzheimers Dement2015
26644572Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques.Proc Natl Acad Sci U S A2015
26141492CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease.Brain2015
26032020Abnormal synaptic Ca(2+) homeostasis and morphology in cortical neurons of familial hemiplegic migraine type 1 mutant mice.Ann Neurol2015
24587111RNA aptamer probes as optical imaging agents for the detection of amyloid plaques.PLoS One2014
24849360Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis.J Neurosci2014
23818064Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models.Acta Neuropathol2013
24259049Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain.Sci Transl Med2013
23903572Mouse gender influences brain transduction by intravascularly administered AAV9.Mol Ther2013
21945540Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease.Neurobiol Dis2012
22496575Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.J Neurosci2012
22378890Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.J Neurosci2012
19654569Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.Mol Ther2010
20164348Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.J Neurosci2010
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Collaborators

Bradley T Hyman
Massachusetts General Hospital
Co-authored papers 28
Rebecca A Betensky
New York University.
Co-authored papers 7
Rachel E Bennett
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 4
Sudeshna Das
Massachusetts General Hospital
Co-authored papers 4
Rudolph E Tanzi
Co-authored papers 3
Anat Stemmer-Rachamimov
Massachusetts General Hospital
Co-authored papers 2
David M Holtzman
Co-authored papers 2
Matthew P Frosch
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 2
Xandra O Breakefield
Massachusetts General Hospital
Co-authored papers 2
Steven M Greenberg
Massachusetts General Hospital
Co-authored papers 2
Ashley B Robbins
University of Pennsylvania
Co-authored papers 1
Arn M J M van den Maagdenberg
Leiden University Medical Center
Co-authored papers 1
Keith A Johnson
Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1
John P Corradi
Hartford Hospital Research Program, Hartford Hospital
Co-authored papers 1
Angela Cacace
O.W.) and University of Rochester Medical Center
Co-authored papers 1
Christian Haass
German Center for Neurodegenerative Diseases (DZNE) Munich
Co-authored papers 1
Sarah C Hopp
University of Texas Health Science Center San Antonio
Co-authored papers 1
Sourav R Choudhury
Co-authored papers 1
Bruce R Rosen
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1
Can Zhang
Co-authored papers 1
Charles R Vanderburg
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 1
Jason D Ulrich
Co-authored papers 1
Michel D Ferrari
Leiden University Medical Center
Co-authored papers 1
Clifford R Jack
Mayo Clinic Rochester
Co-authored papers 1
Cenk Ayata
Neurovascular Research Unit, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1
Timothy Clark (CM4AI)
University of Virginia
Co-authored papers 1
Miwei Hu
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1
Nathan A Bihlmeyer
Johns Hopkins University School of Medicine
Co-authored papers 1
Tim Clark
Co-authored papers 1
Reisa A Sperling
Brigham and Women's Hospital, Massachusetts General Hospital
Co-authored papers 1
Release 1.2