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Author Details

John LaFrancois
Center for Dementia Research, The Nathan Kline Institute for Psychiatric Research
1996
34
23
PMIDPaper TitleJournal TitlePublished Year
37214805Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease.bioRxiv2024
37502909Increasing adult neurogenesis protects mice from epilepsy.bioRxiv2024
36711983Hippocampal area CA2 controls seizure dynamics, interictal EEG abnormalities and social comorbidity in mouse models of temporal lobe epilepsy.bioRxiv2023
35987207Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy.Neuron2022
33472828Bidirectional Regulation of Cognitive and Anxiety-like Behaviors by Dentate Gyrus Mossy Cells in Male and Female Mice.J Neurosci2021
30672046Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures.Hippocampus2019
31775052An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy.Cell Rep2019
31422108Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor.Mol Cell Neurosci2019
29035369Epigenetic suppression of hippocampal calbindin-D28k by οFosB drives seizure-related cognitive deficits.Nat Med2017
28314928Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX.Brain Struct Funct2017
26818394Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology.Sci Rep2016
25476494Suppression of adult neurogenesis increases the acute effects of kainic acid.Exp Neurol2015
25864929Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy.Exp Neurol2015
24534480Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy.Epilepsy Behav2014
25290065p75NTR, but not proNGF, is upregulated following status epilepticus in mice.ASN Neuro2014
24746813proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus.Cell Rep2014
24890981Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination.NMR Biomed2014
17999181Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein.Neurochem Res2008
17314674Antibody against C-terminal Abeta selectively elevates plasma Abeta.Neuroreport2007
17683481Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression.J Neurochem2007
15974928An Abeta sequestration approach using non-antibody Abeta binding agents.Curr Alzheimer Res2005
15867159Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.Proc Natl Acad Sci U S A2005
12514198Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.J Neurosci2003
13678662Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice.Neurobiol Dis2003
12573540Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques.Brain Res Mol Brain Res2003
12843267Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.J Neurosci2003
12765608Cdk5 is a key factor in tau aggregation and tangle formation in vivo.Neuron2003
11796757Modulation of A(beta) peptides by estrogen in mouse models.J Neurochem2002
11440793Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.Neuroscience2001
11290552Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.Am J Pathol2001
11592856A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease.Neurobiol Dis2001
11442360Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.Neurobiol Dis2001
10964604Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.Neurobiol Dis2000
8949958Self-administration of ethanol: towards the location of predisposing polygenes in quasi-congenic animal models.Alcohol1996
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Collaborators

Center for Dementia Research, The Nathan Kline Institute for Psychiatric Research
Co-authored papers 15
Center for Dementia Research, The Nathan Kline Institute for Psychiatric Research
Co-authored papers 6
Co-authored papers 3
Mayo Clinic Jacksonville
Co-authored papers 3
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Co-authored papers 2
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Co-authored papers 2
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University of Pittsburgh
Co-authored papers 1
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Baylor College of Medicine
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