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Author Details

Olivier Lichtarge
Baylor College of Medicine
1981
182
47
PMIDPaper TitleJournal TitlePublished Year
36806686Coevolutionary signals in metabotropic glutamate receptors capture residue contacts and long-range functional interactions.J Biol Chem2023
37709961Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity.Nat Metab2023
37522889ShinyBioHEAT: an interactive shiny app to identify phenotype driver genes in E.coli and B.subtilis.Bioinformatics2023
37577579CAGI6 ID-Challenge: Assessment of phenotype and variant predictions in 415 children with Neurodevelopmental Disorders (NDDs).Res Sq2023
37642027Evolutionary Action-Machine Learning Model Identifies Candidate Genes Associated With Early-Onset Coronary Artery Disease.J Am Heart Assoc2023
37290531CovET: A covariation-evolutionary trace method that identifies protein structure-function modules.J Biol Chem2023
37179358Functional variants identify sex-specific genes and pathways in Alzheimer's Disease.Nat Commun2023
37012319Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.Br J Cancer2023
35301263A general calculus of fitness landscapes finds genes under selection in cancers.Genome Res2022
35846981Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.ACS Pharmacol Transl Sci2022
35680894Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli.Nat Commun2022
35412634EPIMUTESTR: a nearest neighbor machine learning approach to predict cancer driver genes from the evolutionary action of coding variants.Nucleic Acids Res2022
35677076RNA polymerase inaccuracy underlies SARS-CoV-2 variants and vaccine heterogeneity.Res Sq2022
35488922Genome interpretation using in silico predictors of variant impact.Hum Genet2022
36420184Evolutionary Action Score of <i>TP53</i> Analysis in Pathologically High-Risk Human Papillomavirus-Negative Head and Neck Cancer From a Phase 2 Clinical Trial: NRG Oncology Radiation Therapy Oncology Group 0234.Adv Radiat Oncol2022
36268052Identification of risk genes for Alzheimer's disease by gene embedding.Cell Genom2022
33035590Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease.Prog Biophys Mol Biol2021
33576571Harnessing the paradoxical phenotypes of APOE É¿2 and APOE É¿4 to identify genetic modifiers in Alzheimer's disease.Alzheimers Dement2021
33677472Evolutionary action score identifies a subset of TP53 mutated myelodysplastic syndrome with favorable prognosis.Blood Cancer J2021
33636189Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.Prog Biophys Mol Biol2021
34916293Recurrent high-impact mutations at cognate structural positions in class A G protein-coupled receptors expressed in tumors.Proc Natl Acad Sci U S A2021
34966786Decoding Cancer Variants of Unknown Significance for Helicase-Nuclease-RPA Complexes Orchestrating DNA Repair During Transcription and Replication.Front Mol Biosci2021
34439147PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ-DNMT1 Interactions in the Genome.Cancers (Basel)2021
34661078Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.ACS Pharmacol Transl Sci2021
34776222An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2.Methods Enzymol2021
33995922Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esterase.Comput Struct Biotechnol J2021
34043002Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and greater coronavirus family.Bioinformatics2021
34042953Using interpretable deep learning to model cancer dependencies.Bioinformatics2021
34011629A method to delineate de novo missense variants across pathways prioritizes genes linked to autism.Sci Transl Med2021
33106800Identification of evolutionarily stable functional and immunogenic sites across the SARS-CoV-2 proteome and the greater coronavirus family.Res Sq2021
32259836Discovery of disease- and drug-specific pathways through community structures of a literature network.Bioinformatics2020
31797617Graph-based information diffusion method for prioritizing functionally related genes in protein-protein interaction networks.Pac Symp Biocomput2020
31738408Discovery of disease- and drug-specific pathways through community structures of a literature network.Bioinformatics2020
32208421An Evolutionary Trace method defines functionally important bases and sites common to RNA families.PLoS Comput Biol2020
32300106Author Correction: Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.Nat Commun2020
28767562Deleterious Effect of RAS and Evolutionary High-risk TP53 Double Mutation in Colorectal Liver Metastases.Ann Surg2019
31744546The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.Genome Biol2019
31676688Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors.J Biol Chem2019
31501422Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.Nat Commun2019
31301157Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants.Hum Mutat2019
31184403Assessment of methods for predicting the effects of PTEN and TPMT protein variants.Hum Mutat2019
31241222Assessing the performance of in silico methods for predicting the pathogenicity of variants in the gene CHEK2, among Hispanic females with breast cancer.Hum Mutat2019
31209948Evaluating the predictions of the protein stability change upon single amino acid substitutions for the FXN CAGI5 challenge.Hum Mutat2019
31294896Assessment of blind predictions of the clinical significance of BRCA1 and BRCA2 variants.Hum Mutat2019
31317604CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation.Hum Mutat2019
31260570Performance of computational methods for the evaluation of pericentriolar material 1 missense variants in CAGI-5.Hum Mutat2019
31342580Assessment of predicted enzymatic activity of α-N-acetylglucosaminidase variants of unknown significance for CAGI 2016.Hum Mutat2019
31283071Assessing predictions on fitness effects of missense variants in calmodulin.Hum Mutat2019
31509758Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.Cell Rep2019
31365877Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas.Cell Rep2019
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Collaborators

Angela D Wilkins
Baylor College of Medicine
Co-authored papers 23
Rita Casadio
Department of Pharmacy and Biotechnology, University of Bologna
Co-authored papers 14
Pier Luigi Martelli
Department of Pharmacy and Biotechnology, University of Bologna
Co-authored papers 13
Castrense Savojardo
Department of Pharmacy and Biotechnology, University of Bologna
Co-authored papers 10
David Marciano
Stanford Cardiovascular Institute (L.W., Stanford University School of Medicine
Co-authored papers 10
Steven E Brenner
University of California berkeley
Co-authored papers 10
Amanda Koire
Brigham and Women's Hospital, USA 02115 Harvard Medical School
Co-authored papers 9
Predrag Radivojac
Indiana University
Co-authored papers 9
Michel Bouvier
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 8
Lydia E Kavraki
Co-authored papers 8
Eric Venner
Baylor College of Medicine
Co-authored papers 8
Sean D Mooney
University of Washington
Co-authored papers 8
Jeffrey N Myers
The University of Texas MD Anderson Cancer Center
Co-authored papers 7
Brian Y Chen
Co-authored papers 7
Yana Bromberg
Rutgers University
Co-authored papers 7
John Moult
Institute for Bioscience and Biotechnology Research
Co-authored papers 7
Thomas Bourquard
Co-authored papers 6
Silvio C E Tosatto
University of Padova
Co-authored papers 6
Henry R Bourne
Co-authored papers 6
Young-Won Kim
Baylor College of Medicine
Co-authored papers 6
Vikas Pejaver
Institute for Genomic Health, Icahn School of Medicine at Mount Sinai
Co-authored papers 5
Lawrence A Donehower
Baylor College of Medicine
Co-authored papers 5
Mitchell J Frederick
Baylor College of Medicine
Co-authored papers 5
Philippe Froguel
Co-authored papers 4
Marco Carraro
Hematology and Clinical Immunology Unit, University of Padova
Co-authored papers 4
Roland L Dunbrack
Fox Chase Cancer Center
Co-authored papers 4
S??ren P Sheikh
Odense University Hospital
Co-authored papers 4
John A Tainer
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
Fred E Cohen
University of California san francisco
Co-authored papers 4
Yaoqi Zhou
Co-authored papers 4
Release 1.2