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Author Details

Pablo Avil??s
Departamento de Toxicologia y Farmacologia Preclinica
1989
61
19
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36940615Trabectedin modulates macrophage polarization in the tumor-microenvironment. Role of K<sub>V</sub>1.3 and K<sub>V</sub>1.5 channels.Biomed Pharmacother2023
36996147Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.PLoS One2023
35231500Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis.Antiviral Res2022
35806460Plocabulin, a Novel Tubulin Inhibitor, Has Potent Antitumour Activity in Patient-Derived Xenograft Models of Soft Tissue Sarcoma.Int J Mol Sci2022
35012962Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.Life Sci Alliance2022
35042701Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients.Drug Metab Dispos2022
34066159Evaluation of the Preclinical Efficacy of Lurbinectedin in Malignant Pleural Mesothelioma.Cancers (Basel)2021
33495306Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A.Science2021
34075384Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.medRxiv2021
32264921CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110.J Hematol Oncol2020
31812675Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells.Biochem Pharmacol2020
32711367Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.Transl Oncol2020
30831452Development of a new method for the quantitation of metabolites in the absence of chemically synthetized authentic standards.J Pharm Biomed Anal2019
29127040Improved pharmacokinetic profile of lipophilic anti-cancer drugs using ανβ3-targeted polyurethane-polyurea nanoparticles.Nanomedicine2018
29974200Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of <sup>14</sup>C-plitidepsin.Cancer Chemother Pharmacol2018
29883879Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of lurbinectedin in human plasma and urine.J Pharm Biomed Anal2018
29415678Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells.BMC Cancer2018
29440297MI130004, a Novel Antibody-Drug Conjugate Combining Trastuzumab with a Molecule of Marine Origin, Shows Outstanding <i>In Vivo</i> Activity against HER2-Expressing Tumors.Mol Cancer Ther2018
27540138Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone.Haematologica2017
28662481Liquid chromatography-tandem mass spectrometry assay to quantify plitidepsin in human plasma, whole blood and urine.J Pharm Biomed Anal2017
26871278Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of PM01183 (lurbinectedin), a novel antineoplastic agent, in mouse, rat, dog, Cynomolgus monkey and mini-pig plasma.J Pharm Biomed Anal2016
27697767Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.Cancer Res2016
27630271Lurbinectedin Specifically Triggers the Degradation of Phosphorylated RNA Polymerase II and the Formation of DNA Breaks in Cancer Cells.Mol Cancer Ther2016
27780828Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.Dis Model Mech2016
25681727Enhanced in vivo therapeutic efficacy of plitidepsin-loaded nanocapsules decorated with a new poly-aminoacid-PEG derivative.Int J Pharm2015
26295985HPLC-MS/MS method to measure trabectedin in tumors: preliminary PK study in a mesothelioma xenograft model.Bioanalysis2015
24486569PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors.Biochem Pharmacol2014
24758355Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis.BMC Cancer2014
24614852Use of air stacking and abdominal compression for cough assistance in people with complete tetraplegia.Spinal Cord2014
24287622Nano-encapsulation of plitidepsin: in vivo pharmacokinetics, biodistribution, and efficacy in a renal xenograft tumor model.Pharm Res2014
23591661A new potential nano-oncological therapy based on polyamino acid nanocapsules.J Control Release2013
23697951c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity.Mar Drugs2013
22896654Lurbinectedin (PM01183), a new DNA minor groove binder, inhibits growth of orthotopic primary graft of cisplatin-resistant epithelial ovarian cancer.Clin Cancer Res2012
22852480Comparison of pharmacokinetic profiles of PM02734 loaded lipid nanoparticles and cyclodextrins: in vitro and in vivo characterization.J Biomed Nanotechnol2012
21330323Zalypsis has in vitro activity in acute myeloid blasts and leukemic progenitor cells through the induction of a DNA damage response.Haematologica2011
20977459PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumour activity.Br J Pharmacol2010
19020308Zalypsis: a novel marine-derived compound with potent antimyeloma activity that reveals high sensitivity of malignant plasma cells to DNA double-strand breaks.Blood2009
19427997Molecular pharmacology and antitumor activity of Zalypsis in several human cancer cell lines.Biochem Pharmacol2009
19426702In vitro studies on the metabolism of trabectedin (YONDELIS) in monkey and man, including human CYP reaction phenotyping.Biochem Pharmacol2009
18593922Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo.Cancer Res2008
19055929[Risk factors for prolonged mechanical ventilation after cardiac surgery in children].Med Intensiva2008
16497567Quantitative analysis of Variolin analog (PM01218) in mouse and rat plasma by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.J Chromatogr B Analyt Technol Biomed Life Sci2006
16921565Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of PM02734, a novel antineoplastic agent, in dog plasma.Rapid Commun Mass Spectrom2006
15702485Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of PM00104, a novel antineoplastic agent, in mouse, rat, dog, and human plasma.Rapid Commun Mass Spectrom2005
16461533The application of image quality measurements for digital angiography.Radiat Prot Dosimetry2005
16461530Evaluation of risk of deterministic effects in fluoroscopically guided procedures.Radiat Prot Dosimetry2005
14599541Computer-assisted enhanced volumetric segmentation magnetic resonance imaging data using a mixture of artificial neural networks.Magn Reson Imaging2003
12888201Validation of a sensitive assay for thiocoraline in mouse plasma using liquid chromatography-tandem mass spectrometry.J Chromatogr B Analyt Technol Biomed Life Sci2003
12876692Development of a liquid chromatography/tandem mass spectrometry assay for the quantification of Aplidin, a novel marine-derived antineoplastic agent, in human plasma.Rapid Commun Mass Spectrom2003
11968136Monitoring acute inflammatory processes in mouse muscle by MR imaging and spectroscopy: a comparison with pathological results.NMR Biomed2002
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Collaborators

Instituto de Investigaciones Biomedicas "Alberto Sols"
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Clinical Development
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Clinical Development
Co-authored papers 6
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
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Icahn School of Medicine at Mount Sinai
Co-authored papers 3
J. David Gladstone Institutes
Co-authored papers 3
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
University of California San Francisco
Co-authored papers 3
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
Co-authored papers 3
The University of Texas MD Anderson Cancer Center
Co-authored papers 3
University of Geneva
Co-authored papers 3
Hospital Germans Trias i Pujol
Co-authored papers 3
Hospital Infantil Universitario "La Paz"
Co-authored papers 3
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 3
University of California San Francisco
Co-authored papers 3
Department of Pharmaceutical Sciences, Utrecht University
Co-authored papers 3
Hospital Universitario Marques de Valdecilla
Co-authored papers 2
Hospital Universitario HM Monteprincipe, HM Hospitales
Co-authored papers 2
Instituto de Salud Carlos III, Hospital Universitario La Princesa
Co-authored papers 2
Campus Universidad Autonoma de Madrid
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Hospital Universitario Quironsalud Madrid
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Hospital Universitario Ramon y Cajal
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Hospital Universitario de Getafe
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Hospital Universitario de La Princesa
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Universidad Europea
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University College London
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Hospital Universitario de Getafe
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Campus Universidad Autonoma de Madrid
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Clinical R&D
Co-authored papers 2