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Author Details

Shirit Einav
Stanford University School of Medicine
2002
59
28
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34159337Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.bioRxiv2023
37581931Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects.J Clin Invest2023
37812640Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.PLoS Pathog2023
37090561Single B cell transcriptomics identifies multiple isotypes of broadly neutralizing antibodies against flaviviruses.bioRxiv2023
36961888Magnitude and kinetics of the human immune cell response associated with severe dengue progression by single-cell proteomics.Sci Adv2023
37259914Preparing for the next viral threat with broad-spectrum antivirals.J Clin Invest2023
36385995Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents.Front Chem2022
35738348Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies.Antiviral Res2022
35346346An 8-gene machine learning model improves clinical prediction of severe dengue progression.Genome Med2022
35452674The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection.J Biol Chem2022
36549272How can systems approaches help us understand and treat infectious disease?Cell Syst2022
35969644Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX.PLoS Pathog2022
34504321PIKfyve: a lipid kinase target for COVID-19, cancer and neurodegenerative disorders.Nat Rev Drug Discov2021
33788849The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infection.PLoS Negl Trop Dis2021
33497888Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.Eur J Med Chem2021
34885921Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors.Molecules2021
34624490Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV).Bioorg Med Chem Lett2021
32631507Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines.Bioorg Med Chem Lett2020
31757682Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase.Bioorg Med Chem2020
31982232Towards Predicting Progression to Severe Dengue.Trends Microbiol2020
33137362BIKE regulates dengue virus infection and is a cellular target for broad-spectrum antivirals.Antiviral Res2020
32687696Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19.ACS Infect Dis2020
30529544Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines.Eur J Med Chem2019
31820734Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics.Elife2019
31250310Screening of Interactions with the ESCRT Machinery by a Gaussia princeps Split Luciferase-Based Complementation Assay.Methods Mol Biol2019
30759391MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.Cell Rep2019
31136173Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.J Med Chem2019
30699342A 20-Gene Set Predictive of Progression to Severe Dengue.Cell Rep2019
29317514Erratum for Barouch-Bentov et al., "Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment".mBio2018
30043139Viral journeys on the intracellular highways.Cell Mol Life Sci2018
29953812Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity.J Med Chem2018
30530648Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue.Proc Natl Acad Sci U S A2018
29649437Turning Up Your Nose for a Flaviviral Encephalitis Cure.Cell Host Microbe2018
29753658Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment.Antiviral Res2018
29535204Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release.mBio2018
29451494Single-cell transcriptional dynamics of flavivirus infection.Elife2018
29148875Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs.DNA Cell Biol2018
29298032Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs.ACS Infect Dis2018
28240606Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects.J Clin Invest2017
27031829Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus.PLoS Biol2016
27803188Hepatitis C Virus Proteins Interact with the Endosomal Sorting Complex Required for Transport (ESCRT) Machinery via Ubiquitination To Facilitate Viral Envelopment.mBio2016
27044079Pathogen receptor discovery with a microfluidic human membrane protein array.Proc Natl Acad Sci U S A2016
25822739Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents.J Med Chem2015
26925208Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase : synthesis, structure-activity relationship studies and antiviral activity.Medchemcomm2015
26113710Responseâ¿¿Applying antibiotics lessons to antivirals.Science2015
25883340Infectious disease. Combating emerging viral threats.Science2015
25653444AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.J Virol2015
24449209B-cell receptors expressed by lymphomas of hepatitis C virus (HCV)-infected patients rarely react with the viral proteins.Blood2014
22916011Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly.PLoS Pathog2012
20363257A small molecule inhibits HCV replication and alters NS4B's subcellular distribution.Antiviral Res2010
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Collaborators

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Yale University School of Medicine
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Texas Biomedical Research Institute
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Co-authored papers 1
Rutgers New Jersey Medical School
Co-authored papers 1
University of Massachusetts Medical School
Co-authored papers 1
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Co-authored papers 1
University of Washington
Co-authored papers 1
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J. David Gladstone Institutes
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Tufts University School of Engineering
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