Author details

Full Name

Kevin Wiehe

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36924501	Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies.		2023
35962033	Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.	Nature Reviews Immunology	2023
38036525	Engineered immunogens to elicit antibodies against conserved coronavirus epitopes.	Nat Commun	2023
37751363	Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development.		2023
38001122	Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques.		2023
37905016	Computing the inducibility of B cell lineages under a context-dependent model of affinity maturation: Applications to sequential vaccine design.		2023
37986885	Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.	bioRxiv	2023
37874153	Host immunity associated with spontaneous suppression of viremia in therapy-naÃ¯ve young rhesus macaques following neonatal SHIV infection.		2023
36909627	Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes.	bioRxiv	2023
37260077	ARMADiLLO: a web server for analyzing antibody mutation probabilities.		2023
37196027	Identification of CDRH3 loops in the B cell receptor repertoire that can be engaged by candidate immunogens.		2023
36629414	A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies.	mBio	2023
37188681	Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage.		2023
36859597	Author Correction: Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies.		2023
37044090	Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions.	Cell Rep Med	2023
35347236	Mouse and human antibodies bind HLA-E-leader peptide complexes and enhance NK cell cytotoxicity.	Communications Biology	2022
35510865	Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage.	Journal of Virology	2022
36070369	Stabilized HIV-1 envelope immunization induces neutralizing antibodies to the CD4bs and protects macaques against mucosal infection.	Science Translational Medicine	2022
35732171	Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike.	Cell Reports	2022
35319830	Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.	Advanced Science	2022
35294883	mRNA-encoded HIV-1 Env trimer ferritin nanoparticles induce monoclonal antibodies that neutralize heterologous HIV-1 isolates in mice.	Cell Reports	2022
35118469	Structural diversity of the SARS-CoV-2 Omicron spike.		2022
34806332	Strategies for induction of HIV-1 envelope-reactive broadly neutralizing antibodies.	Journal of the International AIDS Society	2021
34242577	In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.	Cell	2021
34019795	Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.	Cell	2021
33971664	Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.	Nature	2021
34168071	Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.	Science	2021
33948590	A broadly neutralizing antibody protects against SARS-CoV, pre-emergent bat CoVs, and SARS-CoV-2 variants in mice.	bioRxiv	2021
33619494	SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys.	bioRxiv	2021
33442694	The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates.	bioRxiv	2021
34086838	Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.	PLoS Pathogens	2021
34407396	Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations.	Cell Reports	2021
34401876	Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles.		2021
34972105	Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques.	PLoS One	2021
34646962	Long-Term Recovery of the Adaptive Immune System in Rhesus Macaques After Total Body Irradiation.	Advances in Radiation Oncology	2021
35069563	Structure and Fc-Effector Function of Rhesusized Variants of Human Anti-HIV-1 IgG1s.	Frontiers in Immunology	2021
32492407	Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.	Cell	2020
32023469	Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization.	Cell Reports	2020
31996483	HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions.	JCI insight	2020
31776278	Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.	Journal of Virology	2020
31479499	Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.	PLoS Pathogens	2019
31806786	Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.	Science	2019
31527908	Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.	PLoS Pathogens	2019
30873178	Antibody-Dependent Cellular Phagocytosis in Antiviral Immune Responses.	Frontiers in Immunology	2019
29549260	HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope.	Nature Communications	2018
30552024	Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.	Immunity	2018
30540944	V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity.	Cell Rep	2018
29861171	Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.		2018
30272013	IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.	Communications Biology	2018
29554083	A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.	Nat Med	2018