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Author Details

Kristian Helin
The Institute of Cancer Research
1988
275
105
Antoine Forget (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36631623The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes.Leukemia2023
37907651Author Correction: H3K4me3 regulates RNA polymerase II promoter-proximal pause-release.Nature2023
37845773Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation.Epigenetics Chromatin2023
37987160An alternative NURF complex sustains acute myeloid leukemia by regulating the accessibility of insulator regions.EMBO J2023
37024580Catching active enhancers via H2B N-terminal acetylation.Nat Genet2023
37436979An organoid-based CRISPR-Cas9 screen for regulators of intestinal epithelial maturation and cell fate.Sci Adv2023
37402365Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1.Mol Cell2023
37369835EZH2i unlocks PDAC immune surveillance.Nat Cancer2023
36959757PR-DUB safeguards Polycomb repression through H2AK119ub1 restriction.Cell Prolif2023
36859550H3K4me3 regulates RNA polymerase II promoter-proximal pause-release.Nature2023
36941349Publisher Correction: H3K4me3 regulates RNA polymerase II promoter-proximal pause-release.Nature2023
34359076Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.Blood2022
35349793Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression.Mol Cell2022
35668298Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals.Nat Genet2022
35421216BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation.Blood2022
35862399Correction: A Screen Identifies the Oncogenic Micro-RNA miR-378a-5p as a Negative Regulator of Oncogene-Induced Senescence.PLoS One2022
35302840H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway.Sci Adv2022
35202573CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency.Mol Cell2022
34582804SATB2 preserves colon stem cell identity and mediates ileum-colon conversion via enhancer remodeling.Cell Stem Cell2022
34031396MPP8 is essential for sustaining self-renewal of ground-state pluripotent stem cells.Nat Commun2021
33657400Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.Mol Cell2021
34667079PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.Life Sci Alliance2021
34663818TET2 mutations are associated with hypermethylation at key regulatory enhancers in normal and malignant hematopoiesis.Nat Commun2021
34848497The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity.Cancer Immunol Res2021
34151298Generation of locus-specific degradable tag knock-ins in mouse and human cell lines.STAR Protoc2021
34009619ChIP-Sequencing of TET Proteins.Methods Mol Biol2021
31518438BTK inhibitors synergise with 5-FU to treat drug-resistant TP53-null colon cancers.J Pathol2020
31896750Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary.Nat Commun2020
32747411PR-DUB maintains the expression of critical genes through FOXK1/2- and ASXL1/2/3-dependent recruitment to chromatin and H2AK119ub1 deubiquitination.Genome Res2020
32669286PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2<sup>V617F</sup>-Mutant MPN.Cancer Discov2020
32641411Mutant FOXL2<sup>C134W</sup> Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors.Cancer Res2020
32231309KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes.Nat Cell Biol2020
30538297HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases.Oncogene2019
31722198A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2.Cell Rep2019
31691806Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.Hum Mol Genet2019
30076673The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase.Acta Physiol (Oxf)2019
31611688PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia.Nat Struct Mol Biol2019
31467927The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.J Diabetes Res2019
31434704The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.Blood2019
31521506Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity.Mol Cell2019
31311845Correction for Danovi et al., "Amplification of <i>Mdmx</i> (or <i>Mdm4</i>) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity".Mol Cell Biol2019
30951652Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.Mol Cell2019
30917958The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.Blood2019
30796038TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.Genome Res2019
30672466PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells.Elife2019
29650963Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.Nat Commun2018
29844126The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.Cancer Res2018
30526604Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity.Mol Cancer2018
29483650Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2.Nat Struct Mol Biol2018
28694333EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice.Mol Cell Biol2017
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Collaborators

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European Institute of Oncology IRCCS
Co-authored papers 27
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Smurfit Institute of Genetics, Trinity College Dublin
Co-authored papers 17
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VILLUM Center for Bioanalytical Sciences, University of Southern Denmark
Co-authored papers 17
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Co-authored papers 10
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Co-authored papers 9
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Memorial Sloan Kettering Cancer Center
Co-authored papers 7
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Memorial Sloan Kettering Cancer Center
Co-authored papers 5
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RIKEN Research Center for Allergy and Immunology
Co-authored papers 4
Frederik Otzen Bagger
Center for Genomic Medicine, Rigshospitalet Copenhagen University Hospital
Co-authored papers 4
Albin Sandelin
University of Copenhagen
Co-authored papers 3
Veit Schw??mmle
University of Southern Denmark
Co-authored papers 3
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Co-authored papers 3
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University Lille, CNRS, INSERM
Co-authored papers 2
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Blavatnik Institute, Harvard Medical School
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Memorial Sloan Kettering Cancer Center
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Sriganesh Jammula
Early Cancer Institute, Hutchison Research Centre, University of Cambridge
Co-authored papers 2
Alex Look
Dana-Farber Cancer Institute
Co-authored papers 2
Robert A Soslow
Co-authored papers 2
Harmen J G van de Werken
Department of Immunology Erasmus University Medical Center
Co-authored papers 2
Torben Heick Jensen
Universitetsbyen 81, Aarhus University
Co-authored papers 2
Britta Weigelt
Memorial Sloan Kettering Cancer Center
Co-authored papers 2
Douglas R Lowy
Co-authored papers 2
Mette J??rgensen
University of Copenhagen
Co-authored papers 2
Edith Heard
Institut Curie, PSL Research University, CNRS UMR 5, INSERM U934
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Jakob Skou Pedersen
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Release 1.2