Author details

Full Name

Clarence Yapp

Affiliation

ORCID

Career Start Year

2013

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37349501	High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers.		2023
36669472	Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer.	Cell	2023
37547011	Addressing persistent challenges in digital image analysis of cancerous tissues.	bioRxiv	2023
34824477	MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging.	Nat Methods	2022
36376301	Multiplexed and reproducible high content screening of live and fixed cells using Dye Drop.	Nat Commun	2022
35973991	Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.	Nat Commun	2022
35972352	Stitching and registering highly multiplexed whole-slide images of tissues and tumors using ASHLAR.		2022
36207580	A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses.	Commun Biol	2022
35926050	Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.	Science	2022
35404441	The Spatial Landscape of Progression and Immunoediting in Primary Melanoma at Single-Cell Resolution.	Cancer Discovery	2022
36419822	Spatial intra-tumor heterogeneity is associated with survival of lung adenocarcinoma patients.	Cell Genomics	2022
34407940	Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.	Science advances	2021
32935109	Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity.		2020
32325060	Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners.	Neuron	2020
32424117	Author Correction: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.	Nat Commun	2020
32193378	Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.	Nat Commun	2020
32015439	HSF1 phase transition mediates stress adaptation and cell fate decisions.	Nat Cell Biol	2020
32231998	Transcriptomic and Functional Screens Reveal MicroRNAs That Modulate Prostate Cancer Metastasis.	Front Oncol	2020
31882401	Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity.	Cancer Research	2020
31812693	Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells.	Cell Syst	2020
31300277	Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners.	Neuron	2019
31848351	Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer.	Sci Data	2019
31427819	Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues.	Nat Biotechnol	2019
29993362	Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes.	eLife	2018
28262558	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.	Cell Chem Biol	2017
28382930	Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.	Nature Communications	2017
28849908	Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.	ACS Chem Biol	2017
28976073	Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.	Angewandte Chemie - International Edition	2017
28963440	Superresolution microscopy of the Î²-carboxysome reveals a homogeneous matrix.	Mol Biol Cell	2017
28265301	Assessing histone demethylase inhibitors in cells: lessons learned.	Epigenetics Chromatin	2017
28265266	HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.	Front Microbiol	2017
26815643	The response of tenocytes to commercial scaffolds used for rotator cuff repair.	European Cells and Materials	2016
26977352	Frapid: achieving full automation of FRAP for chemical probe validation.	Biomedical Optics Express	2016
27388528	H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis.	Arthritis Res Ther	2016
27119626	Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.	J Med Chem	2016
27207294	Using Fluorescence Recovery After Photobleaching to Study Gap Junctional Communication In Vitro.	Methods in Molecular Biology	2016
26345662	Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.	Chemical Communications	2015
25808209	The Mechanical, Structural, and Compositional Changes of Tendon Exposed to Elastase.		2015
26552700	Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy.	Cancer Res	2015
26511510	Inflammation activation and resolution in human tendon disease.	Sci Transl Med	2015
25097667	Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.	Epigenetics Chromatin	2014
24946055	Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains.	J Am Chem Soc	2014
24325601	Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.	Journal of Medicinal Chemistry	2014
24390370	Functional assessment of gap junctions in monolayer and three-dimensional cultures of human tendon cells using fluorescence recovery after photobleaching.	J Biomed Opt	2014
24313754	[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains.	J Med Chem	2014
22974534	A novel in vitro loading system for high frequency loading of cultured tendon fascicles.	Medical Engineering and Physics	2013
26682036	5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.	Chem Sci	2013