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Author Details

Christopher D Kontos
1992
84
40
PMIDPaper TitleJournal TitlePublished Year
36937923Muscle progenitor cells are required for skeletal muscle regeneration and prevention of adipogenesis after limb ischemia.2023
37066299Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells.bioRxiv2023
35315364Pearls of wisdom for aspiring physician-scientist residency applicants and program directors.JCI insight2022
35767962G6PD inhibition sensitizes ovarian cancer cells to oxidative stress in the metastatic omental microenvironment.Cell Rep2022
36266675Using genetically encoded fluorescent biosensors to interrogate ovarian cancer metabolism.Journal of Ovarian Research2022
34417472A systems biology model of junctional localization and downstream signaling of the Ang-Tie signaling pathway.npj Systems Biology and Applications2021
32039914Addressing the physician-scientist pipeline: strategies to integrate research into clinical training programs.Journal of Clinical Investigation2020
30256393Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.Journal of Cellular Physiology2019
31655061Angiopoietin-Tie Signaling Pathway in Endothelial Cells: A Computational Model.iScience2019
29323723Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.Journal of Cellular Physiology2018
28493473Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes.Journal of Cellular Physiology2018
30140897Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.JAMA Cardiol2018
29938246The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease.JACC: Basic to Translational Science2018
27496976Infection-Induced Vascular Permeability Aids Mycobacterial Growth.Journal of Infectious Diseases2017
28611130Precision Medicine for Heart Failure: Lessons From Oncology.Circulation: Heart Failure2017
28442482BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.Circulation2017
28069704Angiopoietin-1 promotes atherosclerosis by increasing the proportion of circulating Gr1+ monocytes.Cardiovascular Research2017
27548526Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling.Journal of Clinical Investigation2016
27403963Methods for Acute and Subacute Murine Hindlimb Ischemia.Journal of Visualized Experiments2016
26254821Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density.Journal of Vascular Surgery2016
26042050Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment.Frontiers in Physiology2015
25608750Angiopoietin-1 enhances skeletal muscle regeneration in mice.American Journal of Physiology - Regulatory Integrative and Comparative Physiology2015
26436659Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.PLoS One2015
25180601Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature.J Clin Invest2014
24355914More than skin deep: connecting melanocyte pigmentation and angiogenic diseases.Journal of Clinical Investigation2014
23274305Gene therapy for the prevention of vein graft disease.Transl Res2013
23899554Inhibiting the inhibitor: targeting vascular endothelial protein tyrosine phosphatase to promote tumor vascular maturation.Journal of the National Cancer Institute2013
22445571Skeletal muscle-specific genetic determinants contribute to the differential strain-dependent effects of hindlimb ischemia in mice.American Journal of Pathology2012
22827996p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.Science Signaling2012
21763734In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.J Control Release2011
21195169Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.Free Radical Biology and Medicine2011
20051384Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.Cardiovascular Research2010
19840194A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use.Journal of Cellular and Molecular Medicine2010
20382861VEGF and soluble VEGF receptor-1 (sFlt-1) distributions in peripheral arterial disease: an in silico model.American Journal of Physiology - Heart and Circulatory Physiology2010
19808686Phosphatase and tensin homologue on chromosome 10 (PTEN) directs prostaglandin E2-mediated fibroblast responses via regulation of E prostanoid 2 receptor expression.J Biol Chem2009
19351908Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport.Physiological Genomics2009
19461044Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide.Circulation Research2009
19325130Endogenous S-nitrosothiols protect against myocardial injury.Proceedings of the National Academy of Sciences of the United States of America2009
18637998A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits.Journal of Sexual Medicine2008
19037734A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function.Angiogenesis2008
19026012Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.Hepatology2008
17912235RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin.Molecular Therapy2008
17950331Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer.Journal of Surgical Research2008
18439153High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue.Journal of Sexual Medicine2008
18652948Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease.Journal of the American College of Cardiology2008
18765664Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells.Journal of Biological Chemistry2008
17440098Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth.Cancer Research2007
17327433In mice with type 2 diabetes, a vascular endothelial growth factor (VEGF)-activating transcription factor modulates VEGF signaling and induces therapeutic angiogenesis after hindlimb ischemia.Diabetes2007
17901375VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.Arteriosclerosis, Thrombosis, and Vascular Biology2007
17823371Impaired angiogenesis after hindlimb ischemia in type 2 diabetes mellitus: differential regulation of vascular endothelial growth factor receptor 1 and soluble vascular endothelial growth factor receptor 1.Circulation Research2007
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