Author details

Full Name

Leslie A Lange

Affiliation

ORCID

Career Start Year

1999

Papers

285

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37546893	Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus.	medRxiv	2023
36444934	Whole-exome sequencing study identifies four novel gene loci associated with diabetic kidney disease.	Hum Mol Genet	2023
38036523	Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease.	Nat Commun	2023
37756531	Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk.	Diabetes Care	2023
37662265	WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.	medRxiv	2023
38014529	Type 2 Diabetes Modifies the Association of CAD Genomic Risk Variants With Subclinical Atherosclerosis.	Circ Genom Precis Med	2023
37630778	The Microbiome, Epigenome, and Diet in Adults with Obesity during Behavioral Weight Loss.		2023
37961394	Lac-Phe mediates the anti-obesity effect of metformin.	bioRxiv	2023
37770635	Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.	Nat Genet	2023
37417779	Mendelian randomization study of diabetes and dementia in the Million Veteran Program.	Alzheimers Dement	2023
37286633	Large scale proteomic studies create novel privacy considerations.	Sci Rep	2023
37216410	Canonical correlation analysis for multi-omics: Application to cross-cohort analysis.	PLoS Genet	2023
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
37471144	The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes.	J Clin Invest	2023
37341347	Plasma neurofilament light chain concentrations are elevated in youth-onset type 2 diabetes and associated with neuropathy.		2023
37398003	Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.	medRxiv	2023
36945581	Mendelian randomization study of diabetes and dementia in the Million Veteran Program.	medRxiv	2023
36941441	Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals.	Nat Genet	2023
36548341	NetSHy: network summarization via a hybrid approach leveraging topological properties.		2023
36463326	Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis.	Int J Obes (Lond)	2023
36791419	Investigating Gene-Diet Interactions Impacting the Association Between Macronutrient Intake and Glycemic Traits.	Diabetes	2023
35263625	Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits.	Am J Hum Genet	2022
36314488	Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study.	Journal of the American Heart Association	2022
36250097	SMOC2 gene interacts with APOL1 in the development of end-stage kidney disease: A genome-wide association study.	Front Med (Lausanne)	2022
35592775	The Value of Rare Genetic Variation in the Prediction of Common Obesity in European Ancestry Populations.	Front Endocrinol (Lausanne)	2022
35653334	A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.	PLoS Genet	2022
36240095	Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke.	Neurology	2022
36041056	A Diabetes Genetic Risk Score Is Associated With All-Cause Dementia and Clinically Diagnosed Vascular Dementia in the Million Veteran Program.	Diabetes Care	2022
35766891	Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data.	Hum Mol Genet	2022
35834496	Alpha globin gene copy number and hypertension risk among Black Americans.	PLoS One	2022
35385699	Polygenic transcriptome risk scores for COPD and lung function improve cross-ethnic portability of prediction in the NHLBI TOPMed program.	Am J Hum Genet	2022
36292585	Differentially Methylated DNA Regions and Left Ventricular Hypertrophy in African Americans: A HyperGEN Study.	Genes (Basel)	2022
35699180	Corin Missense Variants, Blood Pressure, and Hypertension in 11Â 322 Black Individuals: Insights From REGARDS and the Jackson Heart Study.	Journal of the American Heart Association	2022
35697829	Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals.	Commun Biol	2022
36220816	Whole genome sequence analysis of blood lipid levels in >66,000 individuals.	Nat Commun	2022
35811829	Significant Subgraph Detection in Multi-omics Networks for Disease Pathway Identification.	Frontiers in Big Data	2022
35377943	Association of Transthyretin Val122Ile Variant With Incident Heart Failure Among Black Individuals.	JAMA	2022
35995843	Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations.	Commun Biol	2022
35551307	Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.	Nat Genet	2022
36322114	The Impact of Time Horizon on Classification Accuracy: Application of Machine Learning to Prediction of Incident Coronary Heart Disease.	JMIR Cardio	2022
35536696	Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-analysis.	Am J Respir Crit Care Med	2022
35915156	Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.	Nat Med	2022
35467708	Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.	Eur Heart J	2022
36776768	Effective Subject Representation based on Multi-omics Disease Networks using Graph Embedding.		2022
34855941	Association of clonal hematopoiesis with chronic obstructive pulmonary disease.	Blood	2022
34789503	Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol.	Diabetes Care	2022
34672390	Mendelian randomization in the multivariate general linear model framework.	Genet Epidemiol	2022
34727735	Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project.	Stroke	2022
34706968	Alpha Globin Gene Copy Number Is Associated with Prevalent Chronic Kidney Disease and Incident End-Stage Kidney Disease among Black Americans.	J Am Soc Nephrol	2022
35100591	APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort Study.	Am J Nephrol	2022