Author details

Full Name

Amit U Sinha

Affiliation

Memorial Sloan Kettering Cancer Center

ORCID

Career Start Year

2007

Papers

H Index

Expertise

CM4AI Collaborator

Timothy Clark (CM4AI)

PMID	Paper Title	Journal Title	Published Year
37146239	A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth inÂ AML.	Blood	2023
35468619	Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient toÂ induce AML in mice.	Blood Adv	2023
34462525	TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways.	Leukemia	2022
34983288	Deletion of murine <i>Rhoh</i> leads to de-repression of <i>Bcl-6</i> via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma.	Small GTPases	2022
32409690	TET1 promotes growth of T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition.	Leukemia	2021
34226546	The role of the PZP domain of AF10 in acute leukemia driven by AF10 translocations.	Nat Commun	2021
33239784	Splicing factor YBX1 mediates persistence of JAK2-mutated neoplasms.	Nature	2020
29755131	KMT2C mediates the estrogen dependence of breast cancer through regulation of ERÎ± enhancer function.	Oncogene	2018
28516957	ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.	Nat Commun	2017
26927674	MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.	J Clin Invest	2016
27889185	NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.	Cancer Cell	2016
27535106	Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia.	Cancer Discov	2016
26878175	MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.	J Clin Invest	2016
25822366	DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.	Nat Med	2015
24189294	KRas(G12D)-evoked leukemogenesis does not require Î²-catenin.	Leukemia	2014
25464900	AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.	Cancer Cell	2014
24662245	Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia.	Nat Commun	2014
24462619	Active rehabilitation in a pediatric extracorporeal membrane oxygenation patient.	PM R	2014
23361907	Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.	Blood	2013
23428873	DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.	Mol Cell Biol	2013
23235717	Cell of origin determines clinically relevant subtypes of MLL-rearranged AML.	Leukemia	2013
22345515	Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.	Genes Dev	2012
22958934	mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.	Cell Stem Cell	2012
22396593	Polycomb repressive complex 2 is required for MLL-AF9 leukemia.	Proc Natl Acad Sci U S A	2012
22393367	iCanPlot: visual exploration of high-throughput omics data using interactive Canvas plotting.	PLoS One	2012
22388813	Chromatin-modifying enzymes as modulators of reprogramming.	Nature	2012
21741597	MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.	Cancer Cell	2011
22103807	eXframe: reusable framework for storage, analysis and visualization of genomics experiments.	BMC Bioinformatics	2011
20339075	The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.	Science	2010
20332322	MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.	Clin Cancer Res	2010
18229675	Sensitivity analysis for reversal distance and breakpoint reuse in genome rearrangements.	Pac Symp Biocomput	2008
18977325	H3K79 methylation profiles define murine and human MLL-AF4 leukemias.	Cancer Cell	2008
18294391	Dissecting microregulation of a master regulatory network.	BMC Genomics	2008
17343765	Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms.	BMC Bioinformatics	2007

1 - 34 of 34

Hiroko Tanaka

Tokyo Medical and Dental University

Career Start Year 2012

Number of shared co-authors 2

Frederik Otzen Bagger

Center for Genomic Medicine, Rigshospitalet Copenhagen University Hospital

Career Start Year 2012

Number of shared co-authors 3

Alex Murison

Princess Margaret Cancer Centre, University Health Network

Career Start Year 2012

Number of shared co-authors 0

M Ryan Corces

Gladstone Institute of Neurological Disease

Career Start Year 2010

Number of shared co-authors 0

Rahul K Kollipara

McDermott Center for Human Growth and Development.

Career Start Year 2010

Number of shared co-authors 0

Daniel Bottomly

Knight Cancer Institute, Oregon Health & Science University

Career Start Year 2009

Number of shared co-authors 2

Lukas Chavez

University of California San Diego

Career Start Year 2008

Number of shared co-authors 1

Yue Lu

The University of Texas MD Anderson Cancer Center

Career Start Year 2006

Number of shared co-authors 1

Altuna Akalin

Berlin Institute for Medical Systems Biology

Career Start Year 2006

Number of shared co-authors 1

Raj Chari

The National Institutes of Health

Career Start Year 2006

Number of shared co-authors 0

Xiaotu Ma

St. Jude Children's Research Hospital

Career Start Year 2006

Number of shared co-authors 1

Zejuan Li

Houston Methodist Hospital

Career Start Year 2005

Number of shared co-authors 1

Henry Yang

Cancer Science Institute of Singapore, National University of Singapore

Career Start Year 2005

Number of shared co-authors 5

Christoph Bock

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences

Career Start Year 2005

Number of shared co-authors 1

Matthias Schlesner

University of Augsburg

Career Start Year 2004

Number of shared co-authors 0

Etienne Danis

University of Colorado Anschutz Medical Campus

Career Start Year 2004

Number of shared co-authors 4

Jianmin Wang

Roswell Park Comprehensive Cancer Center

Career Start Year 2003

Number of shared co-authors 0

Peter J Park

Harvard Medical School

Career Start Year 2001

Number of shared co-authors 10

Jacqueline E Payton

Washington University School of Medicine.

Career Start Year 2001

Number of shared co-authors 1

Andrew J Gentles

Stanford Center for Biomedical Informatics Research, Stanford University

Career Start Year 1999

Number of shared co-authors 3

Francine E Garrett-Bakelman

University of Virginia

Career Start Year 1999

Number of shared co-authors 6

Ru-Fang Yeh

Genentech Inc.

Career Start Year 1999

Number of shared co-authors 2

Martin Hirst

University of British Columbia

Career Start Year 1998

Number of shared co-authors 1

Benedikt Brors

German Cancer Research Center (DKFZ)

Career Start Year 1997

Number of shared co-authors 0

Robert L Walker

Center for Cancer Research, National Cancer Institute, National Institutes of Health

Career Start Year 1997

Number of shared co-authors 1

Brian J P Huntly

University of Cambridge

Career Start Year 1996

Number of shared co-authors 5

Bradley E Bernstein

Broad Institute of MIT and Harvard

Career Start Year 1994

Number of shared co-authors 9

Marco A Marra

University of British Columbia

Career Start Year 1993

Number of shared co-authors 4

Todd R Golub

Broad Institute of MIT and Harvard

Career Start Year 1989

Number of shared co-authors 10

Christoph Plass

German Cancer Research Center

Career Start Year 1982

Number of shared co-authors 1

row(s) 1 - 30 of 30

Scott A Armstrong

Boston Children's Hospital

Co-authored papers 21

Nan Zhu

Shanghai General Hospital, Shanghai Jiaotong University

Co-authored papers 7

Richard Koche

Memorial Sloan Kettering Cancer Center

Co-authored papers 6

Aniruddha J Deshpande

Sanford Burnham Prebys Medical Discovery Institute

Co-authored papers 6

James E Bradner

Co-authored papers 3

James J Hsieh

Washington University

Co-authored papers 2

Benjamin L Ebert

Co-authored papers 2

Jarek Meller

Co-authored papers 2

Robert G Roeder

the Rockefeller University

Co-authored papers 2

Stuart H Orkin

Boston Children's Hospital and Dana-Farber Cancer Institute, Harvard Medical School

Co-authored papers 2

Anagha Deshpande

Sanford Burnham Prebys Medical Discovery Institute

Co-authored papers 2

Victoria M Richon

Discovery and Preclinical Sciences

Co-authored papers 2

Christopher Y Park

NYU Robert I. Grossman School of Medicine

Co-authored papers 1

Ashok Kumar Jayavelu

German Cancer Research Center (DKFZ)

Co-authored papers 1

Michael F Berger

Co-authored papers 1

William C Hahn

Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute

Co-authored papers 1

Claude Preudhomme

Lille University Hospital, INSERM UMR-S7, CNRS UMR9020, Lille University.

Co-authored papers 1

Clary B Clish

Broad Institute of MIT and Harvard

Co-authored papers 1

Jun Qi

Dana-Farber Cancer Institute

Co-authored papers 1

Francisco Vega

The University of Texas MD Anderson Cancer Center

Co-authored papers 1

Daniel A Pollyea

University of Colorado Division of Hematology

Co-authored papers 1

Veronica Clavijo Jordan

Harvard Medical School

Co-authored papers 1

Thomas Ernst

Universitatsklinikum Jena

Co-authored papers 1

Huafeng Xie

South China University of Technology

Co-authored papers 1

Jing Chen

College of Bioinformatics Science and Technology, Harbin Medical University

Co-authored papers 1

John G Doench

Co-authored papers 1

Elisa de Stanchina

Co-authored papers 1

Timothy Clark (CM4AI)

University of Virginia

Co-authored papers 1

Ronald C Hendrickson

Memorial Sloan Kettering Cancer Center

Co-authored papers 1

Eric S Lander

Vanderbilt-Ingram Cancer Center, Vanderbilt University

Co-authored papers 1

1 - 30

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