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Author Details

Shraddha Thakkar
Center for Drug Evaluations and Research (CDER)
2013
44
16
PMIDPaper TitleJournal TitlePublished Year
37061083Artificial intelligence and real-world data for drug and food safety - A regulatory science perspective.Regul Toxicol Pharmacol2023
37633327DeepAmes: A deep learning-powered Ames test predictive model with potential for regulatory application.Regul Toxicol Pharmacol2023
36425225Adaptability of AI for safety evaluation in regulatory science: A case study of drug-induced liver injury.Front Artif Intell2022
35479329Editorial: Emerging Technologies Powering Rare and Neglected Disease Diagnosis and Theraphy Development.Front Pharmacol2022
35848999Best practice and reproducible science are required to advance artificial intelligence in real-world applications.Brief Bioinform2022
36518910Corrigendum: DeepCarc: Deep learning-powered carcinogenicity prediction using model-level representation.Front Artif Intell2022
33356149Development of a Battery of <i>In Silico</i> Prediction Tools for Drug-Induced Liver Injury from the Vantage Point of Translational Safety Assessment.Chem Res Toxicol2021
33863344Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions.Genome Biol2021
34870186DeepCarc: Deep Learning-Powered Carcinogenicity Prediction Using Model-Level Representation.Front Artif Intell2021
34789871Reporting guidelines for human microbiome research: the STORMS checklist.Nat Med2021
33356151DeepDILI: Deep Learning-Powered Drug-Induced Liver Injury Prediction Using Model-Level Representation.Chem Res Toxicol2021
32558365Imaging the In Vivo Degradation of Tissue Engineering Implants by Use of Supramolecular Radiopaque Biomaterials.Macromol Biosci2020
32032705Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine.Drug Discov Today2020
31669330Drug-induced liver injury severity and toxicity (DILIst): binary classification of 1279 drugs by human hepatotoxicity.Drug Discov Today2020
31808688Can Transcriptomic Profiles from Cancer Cell Lines Be Used for Toxicity Assessment?Chem Res Toxicol2020
33113799Linking Pharmacogenomic Information on Drug Safety and Efficacy with Ethnic Minority Populations.Pharmaceutics2020
33330410Deep Learning on High-Throughput Transcriptomics to Predict Drug-Induced Liver Injury.Front Bioeng Biotechnol2020
33235392FDALabel for drug repurposing studies and beyond.Nat Biotechnol2020
32305367Regulatory landscape of dietary supplements and herbal medicines from a global perspective.Regul Toxicol Pharmacol2020
30871458Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA.BMC Bioinformatics2019
30871470Proceedings of the 2018 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) conference.BMC Bioinformatics2019
28931315The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury.Expert Rev Gastroenterol Hepatol2018
30048704Emerging technologies for food and drug safety.Regul Toxicol Pharmacol2018
29870589Dual Electrospun Supramolecular Polymer Systems for Selective Cell Migration.Macromol Biosci2018
29473853Antioxidant Tocols as Radiation Countermeasures (Challenges to be Addressed to Use Tocols as Radiation Countermeasures in Humans).Antioxidants (Basel)2018
28545815Succinamide derivatives of melampomagnolide B and their anti-cancer activities.Bioorg Med Chem2017
29229971Development of Decision Forest Models for Prediction of Drug-Induced Liver Injury in Humans Using A Large Set of FDA-approved Drugs.Sci Rep2017
29297287Scaling bioinformatics applications on HPC.BMC Bioinformatics2017
29297277Proceedings of the 2017 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.BMC Bioinformatics2017
26948801DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.Drug Discov Today2016
26524538Early in-situ cellularization of a supramolecular vascular graft is modified by synthetic stromal cell-derived factor-1α derived peptides.Biomaterials2016
27766933Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.BMC Bioinformatics2016
27620175PEGylation of a High-Affinity Anti-(+)Methamphetamine Single Chain Antibody Fragment Extends Functional Half-Life by Reducing Clearance.Pharm Res2016
27116022The FDA's Experience with Emerging Genomics Technologies-Past, Present, and Future.AAPS J2016
26999190Comprehensive Assessments of RNA-seq by the SEQC Consortium: FDA-Led Efforts Advance Precision Medicine.Pharmaceutics2016
26022840Heteroaromatic analogs of the resveratrol analog DMU-212 as potent anti-cancer agents.Bioorg Med Chem Lett2015
26424691Proceedings of the 2015 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference.BMC Bioinformatics2015
26445835Decellularized Extracellular Matrix Scaffolds for Cartilage Regeneration.Methods Mol Biol2015
26578342Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein.Sci Rep2015
27066215Synthesis and anti-cancer screening of novel heterocyclic-(2<i>H</i>)-1,2,3-triazoles as potential anti-cancer agents.Medchemcomm2015
26159352A Nanotechnology-Based Platform for Extending the Pharmacokinetic and Binding Properties of Anti-methamphetamine Antibody Fragments.Sci Rep2015
24419156Affinity improvement of a therapeutic antibody to methamphetamine and amphetamine through structure-based antibody engineering.Sci Rep2014
24648045Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailability.Drug Dev Res2014
23443652Mesenchymal stromal cell-derived extracellular matrix influences gene expression of chondrocytes.Biofabrication2013
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Collaborators

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National Center for Toxicological Research
Co-authored papers 25
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Joshua Xu
Co-authored papers 7
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National Center for Toxicological Research (NCTR)
Co-authored papers 6
Stephen C Harris
Co-authored papers 3
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Co-authored papers 3
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Co-authored papers 3
Huixiao Hong
Co-authored papers 3
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Virginia Commonwealth University
Co-authored papers 3
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Wendell D Jones
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Tieliu Shi
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Andre Franke
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Suzanne Devkota
David Geffen School of Medicine, University of California Los Angeles
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Harry Sokol
Paris Center for Microbiome Medicine
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Mingyu Zhang
Johns Hopkins Bloomberg School of Public Health
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Ludwig Geistlinger
Center for Computational Biomedicine, Harvard Medical School
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Anthony A Fodor
University of North Carolina at Charlotte
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Noel T Mueller
Johns Hopkins Bloomberg School of Public Health
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Release 1.2