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Author Details

Lefkos T Middleton
Ageing Epidemiology Research Unit, School of Public Health, Imperial College London
1988
139
51
PMIDPaper TitleJournal TitlePublished Year
36869989Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England: a retrospective cohort study.Eur J Epidemiol2023
37480114Lipopolysaccharide-binding protein and future Parkinson's disease risk: a European prospective cohort.J Neuroinflammation2023
37675653Prediagnostic Blood Metal Levels and the Risk of Parkinson's Disease: A Large European Prospective Cohort.Mov Disord2023
37357264Editorial: What Is Reasonable and Necessary for Alzheimer Patients from Randomized Clinical Trials to Clinical Practice?J Prev Alzheimers Dis2023
37395154Dementia risk in patients with type 2 diabetes: Comparing metformin with no pharmacological treatment.Alzheimers Dement2023
35098969Blood Derived Amyloid Biomarkers for Alzheimer's Disease Prevention.J Prev Alzheimers Dis2022
36496454Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia.Nat Commun2022
36382223Common signatures of differential microRNA expression in Parkinson's and Alzheimer's disease brains.Brain Commun2022
35875808Practice Effect of Repeated Cognitive Tests Among Older Adults: Associations With Brain Amyloid Pathology and Other Influencing Factors.Front Aging Neurosci2022
35098975At a Glance: An Update on Neuroimaging and Retinal Imaging in Alzheimer's Disease and Related Research.J Prev Alzheimers Dis2022
35098977Associations of Cardiovascular and Non-Cardiovascular Comorbidities with Dementia Risk in Patients with Diabetes: Results from a Large UK Cohort Study.J Prev Alzheimers Dis2022
35098967Editorial: Dementia Prevention: A Global Challenge in Urgent Need of Solutions.J Prev Alzheimers Dis2022
33068316Blood Metal Levels and Amyotrophic Lateral Sclerosis Risk: A Prospective Cohort.Ann Neurol2021
33575718Vitamin B12 and Folate Status in Cognitively Healthy Older Adults and Associations with Cognitive Performance.J Nutr Health Aging2021
34869170Health, Lifestyle, and Psycho-Social Determinants of Poor Sleep Quality During the Early Phase of the COVID-19 Pandemic: A Focus on UK Older Adults Deemed Clinically Extremely Vulnerable.Front Public Health2021
34433606Impact of social restrictions during the COVID-19 pandemic on the physical activity levels of adults aged 50-92 years: a baseline survey of the CHARIOT COVID-19 Rapid Response prospective cohort study.BMJ Open2021
34035076Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large U.K. Cohort Study.Diabetes Care2021
34168021Protocol of the Cognitive Health in Ageing Register: Investigational, Observational and Trial Studies in Dementia Research (CHARIOT): Prospective Readiness cOhort (PRO) SubStudy.BMJ Open2021
31511340Distal hereditary motor neuronopathy of the Jerash type is caused by a novel <i>SIGMAR1</i> c.500A&gt;T missense mutation.J Med Genet2020
33276490Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases.Cells2020
33132942Associations of Social Isolation with Anxiety and Depression During the Early COVID-19 Pandemic: A Survey of Older Adults in London, UK.Front Psychiatry2020
32885022Transition from physical to virtual visit format for a longitudinal brain aging study, in response to the Covid-19 pandemic. Operationalizing adaptive methods and challenges.Alzheimers Dement (N Y)2020
32627328World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia.Alzheimers Dement2020
32357270Alcohol Consumption and Risk of Parkinson's Disease: Data From a Large Prospective European Cohort.Mov Disord2020
32347983Mitochondrial Complex 1, Sigma 1, and Synaptic Vesicle 2A in Early Drug-Naive Parkinson's Disease.Mov Disord2020
31324712Characterization of 3 PET Tracers for Quantification of Mitochondrial and Synaptic Function in Healthy Human Brain: <sup>18</sup>F-BCPP-EF, <sup>11</sup>C-SA-4503, and <sup>11</sup>C-UCB-J.J Nucl Med2020
30690664Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.Acta Neuropathol2019
31788537Alzheimer's disease pathology explains association between dementia with Lewy bodies and APOE-ε4/TOMM40 long poly-T repeat allele variants.Alzheimers Dement (N Y)2019
31495604Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid.Alzheimers Dement2019
31256117Cortisol, Amyloid-β, and Reserve Predicts Alzheimer's Disease Progression for Cognitively Normal Older Adults.J Alzheimers Dis2019
31564609Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a "gray zone"?Alzheimers Dement2019
30772279General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study.Parkinsonism Relat Disord2019
30990912Meta-analyses identify differentially expressed micrornas in Parkinson's disease.Ann Neurol2019
30462234Exploring causality of the association between smoking and Parkinson's disease.Int J Epidemiol2019
28849371MSA prions exhibit remarkable stability and resistance to inactivation.Acta Neuropathol2018
28213437α-Synuclein: Multiple System Atrophy Prions.Cold Spring Harb Perspect Med2018
27599208Systematic evaluation of the associations between environmental risk factors and dementia: An umbrella review of systematic reviews and meta-analyses.Alzheimers Dement2017
28260527Genetics of vascular dementia - review from the ICVD working group.BMC Med2017
26968841Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study.Eur J Epidemiol2016
26527105Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases.Neuropathol Appl Neurobiol2016
27806707Is the time ripe for new diagnostic criteria of cognitive impairment due to cerebrovascular disease? Consensus report of the International Congress on Vascular Dementia working group.BMC Med2016
27091628α-synuclein genetic variability: A biomarker for dementia in Parkinson disease.Ann Neurol2016
26710325Why has therapy development for dementia failed in the last two decades?Alzheimers Dement2016
26756745Associations between TOMM40 Poly-T Repeat Variants and Dementia in Cases with Parkinsonism.J Parkinsons Dis2016
26286986Propagation of prions causing synucleinopathies in cultured cells.Proc Natl Acad Sci U S A2015
26599631Development of the CHARIOT Research Register for the Prevention of Alzheimer's Dementia and Other Late Onset Neurodegenerative Diseases.PLoS One2015
26324905Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Proc Natl Acad Sci U S A2015
26375921Parkinson's Disease Case Ascertainment in the EPIC Cohort: The NeuroEPIC4PD Study.Neurodegener Dis2015
24252062A novel GBA2 gene missense mutation in spastic ataxia.Ann Hum Genet2014
24809401Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.Br J Psychiatry2014
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Centre hospitalier universitaire vaudois
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UK Dementia Research Institute Centre at Imperial College London
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Weill Institute for Neurosciences, University of California San Francisco
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