Author details

Full Name

Gregory V Kryukov

Affiliation

ORCID

Career Start Year

1999

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37623743	STX-478, a Mutant-Selective, Allosteric PI3KÎ± Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3KÎ±-Mutant Xenografts.		2023
37712571	Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science.		2023
35084050	Implementation of a prostate cancer-specific targeted sequencing panel for credentialing of patient-derived cell lines and genomic characterization of patient samples.	Prostate	2022
31068700	Next-generation characterization of the Cancer Cell Line Encyclopedia.	Nature	2019
30559381	Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.	Nature	2019
31068703	The landscape of cancer cell line metabolism.	Nat Med	2019
28753430	Defining a Cancer Dependency Map.	Cell	2017
28805821	Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.	Nat Med	2017
27645994	Selenoprotein Gene Nomenclature.	J Biol Chem	2016
27329820	Integrated genetic and pharmacologic interrogation of rare cancers.	Nat Commun	2016
26912360	MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells.	Science	2016
27260156	Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.	Cancer Discov	2016
26631610	Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors.	Clin Cancer Res	2016
27515585	Analysis of cancer genomes reveals basic features of human aging and its role in cancer development.	Nat Commun	2016
26657580	TERT promoter mutations and monoallelic activation of TERT in cancer.	Oncogenesis	2015
25096233	Somatic ERCC2 mutations correlate with cisplatin sensitivity in muscle-invasive urothelial carcinoma.	Cancer Discov	2014
24265154	MAP kinase pathway alterations in BRAF-mutant melanoma patients with acquired resistance to combined RAF/MEK inhibition.	Cancer Discov	2014
24265153	The genetic landscape of clinical resistance to RAF inhibition in metastatic melanoma.	Cancer Discov	2014
24836576	Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.	Nat Med	2014
24562383	ARID1B is a specific vulnerability in ARID1A-mutant cancers.	Nat Med	2014
23622249	Punctuated evolution of prostate cancer genomes.	Cell	2013
24162815	Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.	Nat Med	2013
23770567	Mutational heterogeneity in cancer and the search for new cancer-associated genes.	Nature	2013
24076604	Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.	Nat Genet	2013
23993102	An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.	Cell	2013
23852170	An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers.	Nat Genet	2013
23348506	Highly recurrent TERT promoter mutations in human melanoma.	Science	2013
23388632	Impact of deleterious passenger mutations on cancer progression.	Proc Natl Acad Sci U S A	2013
22607975	Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.	Mol Cell	2012
22460905	The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.	Nature	2012
22323457	iSyTE: integrated Systems Tool for Eye gene discovery.	Invest Ophthalmol Vis Sci	2012
22817889	A landscape of driver mutations in melanoma.	Cell	2012
21993625	Genome sequencing reveals insights into physiology and longevity of the naked mole rat.	Nature	2011
21798893	The mutational landscape of head and neck squamous cell carcinoma.	Science	2011
20471002	Pooled association tests for rare variants in exon-resequencing studies.	Am J Hum Genet	2010
19287383	Human mutation rate associated with DNA replication timing.	Nat Genet	2009
19202052	Power of deep, all-exon resequencing for discovery of human trait genes.	Proc Natl Acad Sci U S A	2009
19525355	Multiplex padlock targeted sequencing reveals human hypermutable CpG variations.	Genome Res	2009
17916946	New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea.	Biol Trace Elem Res	2007
17640883	Widely distributed noncoding purifying selection in the human genome.	Proc Natl Acad Sci U S A	2007
17357083	Medical sequencing at the extremes of human body mass.	Am J Hum Genet	2007
17357078	Most rare missense alleles are deleterious in humans: implications for complex disease and association studies.	Am J Hum Genet	2007
17337453	Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern.	J Biol Chem	2007
16428245	The Plasmodium selenoproteome.	Nucleic Acids Res	2006
16713651	Is there a twenty third amino acid in the genetic code?	Trends Genet	2006
15994173	Small fitness effect of mutations in highly conserved non-coding regions.	Hum Mol Genet	2005
15843685	Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome?	Nucleic Acids Res	2005
16204190	Evolutionary constraints in conserved nongenic sequences of mammals.	Genome Res	2005
14710190	Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution.	EMBO Rep	2004
15317934	Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.	Proc Natl Acad Sci U S A	2004