Author details

Full Name

David W Speicher

Affiliation

ORCID

Career Start Year

1974

Papers

282

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
38011676	Evaluation of novel biomarkers for early pregnancy outcome predictionâ¿ .	Biol Reprod	2024
36795483	Lysosomal lipid peroxidation regulates tumor immunity.	J Clin Invest	2023
36331284	Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition.	Cancer Discov	2023
37715129	Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancy.	Clin Proteomics	2023
37205503	Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis.	bioRxiv	2023
37142218	Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression.	J Biol Chem	2023
37262099	Regulation of EBNA1 protein stability and DNA replication activity by PLOD1 lysine hydroxylase.		2023
35177476	Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability.	Proc Natl Acad Sci U S A	2022
35835783	HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8<sup>+</sup> T-cell infiltration into tumors.	Nat Commun	2022
35650435	Stromal changes in the aged lung induce an emergence from melanoma dormancy.	Nature	2022
36220073	Peroxynitrite in the tumor microenvironment changes the profile of antigens allowing escape from cancer immunotherapy.	Cancer Cell	2022
36278493	PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma.	JCI insight	2022
36261012	Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis.	Cell Rep	2022
35046531	Pyruvate dehydrogenase inactivation causes glycolytic phenotype in BAP1 mutant uveal melanoma.	Oncogene	2022
35189928	Proteome-defined changes in cellular pathways for decidua and trophoblast tissues associated with location and viability of early-stage pregnancy.	Reprod Biol Endocrinol	2022
35223838	Protein Posttranslational Signatures Identified in COVID-19 Patient Plasma.	Frontiers in Cell and Developmental Biology	2022
34433563	A cancer ubiquitome landscape identifies metabolic reprogramming as target of Parkin tumor suppression.	Sci Adv	2021
34019293	Measuring MYC-Mediated Metabolism in Tumorigenesis.	Methods Mol Biol	2021
33485378	Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy.	Breast Cancer Research	2021
33510355	Correction to: BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.	Oncogene	2021
34085048	Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma.	Nat Cancer	2021
33497421	A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism.	PLoS Pathog	2021
33208912	BAP1 mutant uveal melanoma is stratified by metabolic phenotypes with distinct vulnerability to metabolic inhibitors.	Oncogene	2021
34462276	Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance.	Cancer Res	2021
32723812	The mitophagy effector FUNDC1 controls mitochondrial reprogramming and cellular plasticity in cancer cells.	Sci Signal	2020
32075966	Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence.	Nature Communications	2020
31942031	MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer.	Br J Cancer	2020
33023943	A Novel Inhibitor of HSP70 Induces Mitochondrial Toxicity and Immune Cell Recruitment in Tumors.	Cancer Res	2020
32897053	Xe NMR-Protein Sensor Reveals Cellular Ribose Concentration.	Analytical Chemistry	2020
32780726	PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma.	JCI insight	2020
31097545	Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth.	J Biol Chem	2019
31591261	Uncovering Thousands of New Peptides with Sequence-Mask-Search Hybrid De Novo Peptide Sequencing Framework.	Mol Cell Proteomics	2019
31582380	MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer.	Cancer Res	2019
30442709	PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer.	Cancer Discov	2019
30422902	S100A14 Is Increased in Activated NK Cells and Plasma of HIV-Exposed Seronegative People Who Inject Drugs and Promotes Monocyte-NK Crosstalk.	J Acquir Immune Defic Syndr	2019
30279173	Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility.	Cancer Discov	2019
31038472	Aberrant splicing contributes to severe Î±-spectrin-linked congenital hemolytic anemia.	Journal of Clinical Investigation	2019
31180188	Proteome Analysis Using Gel-LC-MS/MS.	Current Protocols in Protein Science	2019
31131328	ARID1A spatially partitions interphase chromosomes.	Sci Adv	2019
30747488	Experimental Assignment of Disulfide-Bonds in Purified Proteins.	Current Protocols in Protein Science	2019
31406245	Akt phosphorylation of mitochondrial Lonp1 protease enables oxidative metabolism and advanced tumor traits.	Oncogene	2019
31061095	Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis.	Mol Cell Biol	2019
30778219	NAD<sup>+</sup> metabolism governs the proinflammatory senescence-associated secretome.	Nat Cell Biol	2019
29363540	Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance.	Blood	2018
30586895	Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase Aâ¿¿ Activity at Cytoplasmic pH.	Antioxidants	2018
30297712	SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells.	Nat Commun	2018
30282979	CLIC1 and CLIC4 complement CA125 as a diagnostic biomarker panel for all subtypes of epithelial ovarian cancer.	Sci Rep	2018
29898993	Syntaphilin Ubiquitination Regulates Mitochondrial Dynamics and Tumor Cell Movements.	Cancer Res	2018
29530483	Exosomal Î±vÎ²6 integrin is required for monocyte M2 polarization in prostate cancer.	Matrix Biol	2018
29434212	CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity.	Nat Commun	2018