Author details

Full Name

Hui Geng

Affiliation

ORCID

Career Start Year

2006

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37098956	Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.		2023
35283191	Antigenic analysis of the HIV-1 envelope trimer implies small differences between structural states 1 and 2.	Journal of Biological Chemistry	2022
35783486	Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (Trimer 4571) vaccine in healthy adults: A first-in-human open-label, randomized, dose-escalation, phase 1 clinical trial.	eClinicalMedicine	2022
34986348	Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys.	Cell Rep	2022
34408080	Blocking Î±Î² integrin delays viral rebound in SHIV-infected macaques treated with anti-HIV broadly neutralizing antibodies.	Science Translational Medicine	2021
34020817	A non-affinity purification process for GMP production of prefusion-closed HIV-1 envelope trimers from clades A and C for clinical evaluation.	Vaccine	2021
33826898	Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base.	Cell Reports	2021
33649208	Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.	Proc Natl Acad Sci U S A	2021
33121334	Removal of variable domain -linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies.	mAbs	2020
32268107	Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.	Cell Rep	2020
32295908	Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses.	Journal of Virology	2020
32755575	Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature.	Cell Rep	2020
30995238	Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting.	PLoS One	2019
31348886	Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.	Cell	2019
29902444	Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer.		2018
29867235	Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.	Nat Med	2018
28275193	Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity.	Journal of Virology	2017
28825711	Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.	Nature Chemical Biology	2017
28445724	Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.	Cell Rep	2017
29212041	Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.	Cell Reports	2017
22277660	Biochemical analysis of the human mismatch repair proteins hMutSÎ± MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D).	Journal of Biological Chemistry	2012
21946537	Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells.	Nat Med	2011
21329650	In vitro studies of DNA mismatch repair proteins.	Analytical Biochemistry	2011
21145359	Control of nuclear HIPK2 localization and function by a SUMO interaction motif.		2011
19270718	Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination.	EMBO Reports	2009
16407239	Inducible phosphorylation of NF-kappa B p65 at serine 468 by T cell costimulation is mediated by IKK epsilon.	Journal of Biological Chemistry	2006