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Author Details

Greg Lemke
Salk Institute for Biological Studies
1980
148
77
PMIDPaper TitleJournal TitlePublished Year
37673933Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase Mer.Commun Biol2023
37572655CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.Immunity2023
36191221Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.Proc Natl Acad Sci U S A2022
35731195The dense-core plaques of Alzheimer's disease are granulomas.J Exp Med2022
36472212Adaptable toolbox to characterize Alzheimer's disease pathology in mouse models.STAR Protoc2022
35967387The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages.Front Immunol2022
36327895Microglia states and nomenclature: A field at its crossroads.Neuron2022
33859405Microglia use TAM receptors to detect and engulf amyloid β plaques.Nat Immunol2021
32488201Blood clots and TAM receptor signalling in COVID-19 pathogenesis.Nat Rev Immunol2020
31896673Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome.J Neurosci2020
32937105A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.Cell2020
32571802Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer.Life Sci Alliance2020
31019284How macrophages deal with death.Nat Rev Immunol2019
30980657TAM receptors in cardiovascular disease.Cardiovasc Res2019
28734578Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands.Trends Biochem Sci2017
28111081Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia.Neuron2017
28322188A molecular mechanism for the topographic alignment of convergent neural maps.Elife2017
28639625MicroRNA-34a dependent regulation of AXL controls the activation of dendritic cells in inflammatory arthritis.Nat Commun2017
27049947TAM receptors regulate multiple features of microglial physiology.Nature2016
25605971A ligand for ALK.Sci Signal2015
26676577Adopting ALK and LTK.Proc Natl Acad Sci U S A2015
26523970The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity.Nat Med2015
26140597Monoclonal 1- and 3-Phosphohistidine Antibodies: New Tools to Study Histidine Phosphorylation.Cell2015
25695599Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells.Cell Death Dis2015
25194421Diversification of TAM receptor tyrosine kinase function.Nat Immunol2014
25265470Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.Elife2014
25258411Stephen F. Heinemann: A true original.Proc Natl Acad Sci U S A2014
23325690Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus?J Virol2013
24186067Biology of the TAM receptors.Cold Spring Harb Perspect Biol2013
23850380T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.Immunity2013
23954153Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.Cell Host Microbe2013
22095910VAX1 mutation associated with microphthalmia, corpus callosum agenesis, and orofacial clefting: the first description of a VAX1 phenotype in humans.Hum Mutat2012
23259948Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis.Neuron2012
23084921The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry.Cell Host Microbe2012
23071254Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.J Exp Med2012
21753007Genetic dissection of EphA receptor signaling dynamics during retinotopic mapping.J Neurosci2011
22157225Dominant-negative isoforms of Tcf/Lef proteins in development and disease.Cell Cycle2011
21805534Transcriptome analysis of neural progenitor cells by a genetic dual reporter strategy.Stem Cells2011
21856776A novel mechanism for the transcriptional regulation of Wnt signaling in development.Genes Dev2011
21030229TAM receptor signaling and autoimmune disease.Curr Opin Immunol2010
20958312TAM receptors and the clearance of apoptotic cells.Ann N Y Acad Sci2010
19501646Disturbed distribution of proliferative brain cells during lupus-like disease.Brain Behav Immun2009
19729839Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis.J Clin Invest2009
19804762Retinal input instructs alignment of visual topographic maps.Cell2009
19380252The PI3K-PTEN tug-of-war, oxidative stress and retinal degeneration.Trends Mol Med2009
18188450Role of Gas6 in erythropoiesis and anemia in mice.J Clin Invest2008
18787040Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration.Mol Endocrinol2008
18997061Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium.Genes Dev2008
18995810Isolation and analysis of the gene encoding peripheral myelin protein zero.Neuron2008
18403711Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling.Science2008
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Collaborators

Novartis Pharma AG
Co-authored papers 14
University of California, University of California Irvine
Co-authored papers 10
David Geffen School of Medicine, University of California-Los Angeles
Co-authored papers 7
Co-authored papers 5
Columbia University
Co-authored papers 3
Washington University School of Medicine
Co-authored papers 2
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Co-authored papers 2
Co-authored papers 2
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Co-authored papers 1
The Ludwig Institute for Cancer Research
Co-authored papers 1
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Mater Research Institute-UQ, Translational Research Institute
Co-authored papers 1
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University of Lausanne
Co-authored papers 1
Salk Institute for Biological Studies
Co-authored papers 1
Wihuri Research Institute
Co-authored papers 1
Weizmann Institute of Science
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Co-authored papers 1
Co-authored papers 1
University of California
Co-authored papers 1
American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University
Co-authored papers 1
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Princess Margaret Cancer Centre, University Health Network
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Roche Pharma
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University of Rochester Medical Center
Co-authored papers 1