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Author Details

Julie D Forman-Kay
Hospital for Sick Children
1989
195
74
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37824065A FRET-Based Assay and Computational Tools to Quantify Enzymatic Rates and Explore the Mechanisms of RNA Deadenylases in Heterogeneous Environments.Methods Mol Biol2024
36496075Surface electrostatics dictate RNA-binding protein CAPRIN1 condensate concentration and hydrodynamic properties.J Biol Chem2023
37917924The Energetic Origins of Pi-Pi Contacts in Proteins.J Am Chem Soc2023
37595014Delineating Structural Propensities of the 4E-BP2 Protein via Integrative Modeling and Clustering.J Phys Chem B2023
38060268Local Disordered Region Sampling (LDRS) for ensemble modeling of proteins with experimentally undetermined or low confidence prediction segments.Bioinformatics2023
37546943Local Disordered Region Sampling (LDRS) for Ensemble Modeling of Proteins with Experimentally Undetermined or Low Confidence Prediction Segments.bioRxiv2023
37878721Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2.Proc Natl Acad Sci U S A2023
37016021Aberrant phase separation: linking IDR mutations to disease.Cell Res2023
37144719Learning to evolve structural ensembles of unfolded and disordered proteins using experimental solution data.J Chem Phys2023
36963488Exploration of O-GlcNAc transferase glycosylation sites reveals a target sequence compositional bias.J Biol Chem2023
37028411Transitions in the framework of condensate biology.Mol Cell2023
36749957Learning Correlations between Internal Coordinates to Improve 3D Cartesian Coordinates for Proteins.J Chem Theory Comput2023
34772786What are the distinguishing features and size requirements of biomolecular condensates and their implications for RNA-containing condensates?RNA2022
35841142Multisite phosphorylation and binding alter conformational dynamics of the 4E-BP2 protein.Biophys J2022
35767567Discovering molecular features of intrinsically disordered regions by using evolution for contrastive learning.PLoS Comput Biol2022
36416859NMR insights into dynamic, multivalent interactions of intrinsically disordered regions: from discrete complexes to condensates.Essays Biochem2022
36040869Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory.Proc Natl Acad Sci U S A2022
36030416IDPConformerGenerator: A Flexible Software Suite for Sampling the Conformational Space of Disordered Protein States.J Phys Chem A2022
36259463A spatiotemporal reconstruction of the <i>C. elegans</i> pharyngeal cuticle reveals a structure rich in phase-separating proteins.Elife2022
36009025An Interpretable Machine-Learning Algorithm to Predict Disordered Protein Phase Separation Based on Biophysical Interactions.Biomolecules2022
35213160Protein Dynamics to Define and Refine Disordered Protein Ensembles.J Phys Chem B2022
34524948Global Proximity Interactome of the Human Macroautophagy Pathway.Autophagy2022
33450720Phosphorylation-dependent regulation of messenger RNA transcription, processing and translation within biomolecular condensates.Curr Opin Cell Biol2021
33616531Identifying molecular features that are associated with biological function of intrinsically disordered protein regions.Elife2021
33810353Configurational Entropy of Folded Proteins and Its Importance for Intrinsically Disordered Proteins.Int J Mol Sci2021
33523862Recessive <i>NOS1AP</i> variants impair actin remodeling and cause glomerulopathy in humans and mice.Sci Adv2021
34074792Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase.Proc Natl Acad Sci U S A2021
34290090FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation.Sci Adv2021
34304571<i>O</i>-Linked-<i>N</i>-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics.J Am Chem Soc2021
33305318PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins.Nucleic Acids Res2021
30224722Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.Mol Psychiatry2020
31999954Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.Mol Cell2020
31898464NMR Experiments for Studies of Dilute and Condensed Protein Phases: Application to the Phase-Separating Protein CAPRIN1.J Am Chem Soc2020
33139563Comparative roles of charge, <i>Ï¿</i>, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins.Proc Natl Acad Sci U S A2020
33357399Phase Separation as a Missing Mechanism for Interpretation of Disease Mutations.Cell2020
32775701Extended Experimental Inferential Structure Determination Method in Determining the Structural Ensembles of Disordered Protein States.Commun Chem2020
32985656Whence Blobs? Phylogenetics of functional protein condensates.Biochem Soc Trans2020
32840111Conformational Ensembles of an Intrinsically Disordered Protein Consistent with NMR, SAXS, and Single-Molecule FRET.J Am Chem Soc2020
32561718Non-cooperative 4E-BP2 folding with exchange between eIF4E-binding and binding-incompatible states tunes cap-dependent translation inhibition.Nat Commun2020
30765518Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.Proc Natl Acad Sci U S A2019
33267376Entropy and Information within Intrinsically Disordered Protein Regions.Entropy (Basel)2019
31439799Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.Science2019
31299205Translating Material Science into Biological Function.Mol Cell2019
31264965Proteome-wide signatures of function in highly diverged intrinsically disordered regions.Elife2019
31626750Properties of Stress Granule and P-Body Proteomes.Mol Cell2019
31282150Oxidative Inhibition of Pbp1 Phase Separation.Biochemistry2019
31252218First-generation predictors of biological protein phase separation.Curr Opin Struct Biol2019
31189070Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis.Am J Respir Cell Mol Biol2019
28866450CFTR structure.J Cyst Fibros2018
29913160RGG/RG Motif Regions in RNA Binding and Phase Separation.J Mol Biol2018
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Collaborators

Lewis E Kay
University of Toronto
Co-authored papers 51
Tony Pawson
Co-authored papers 15
Angela M Gronenborn
University of Pittsburgh
Co-authored papers 7
Irina Bezsonova
University of Connecticut Health Center
Co-authored papers 7
Daniela Rotin
The Hospital for Sick Children
Co-authored papers 7
Mike Tyers
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 6
Jeffrey L Wrana
Lunenfeld-Tanenbaum Research Institute Mount Sinai Hospital
Co-authored papers 5
Alan R Davidson
University of Toronto, University Avenue
Co-authored papers 4
Vladimir N Uversky
Morsani College of Medicine, University of South Florida
Co-authored papers 3
Dmitry M Korzhnev
University of Connecticut Health Center
Co-authored papers 3
Peter Tompa
VIB-VUB Center for Structural Biology
Co-authored papers 3
Joel L Sussman
Weizmann Institute of Science
Co-authored papers 2
Tanja Kortemme
University of California san francisco
Co-authored papers 2
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 2
Mihaly Varadi
European Bioinformatics Institute
Co-authored papers 2
Dmitri I Svergun
King's College London BHF Centre for Research Excellence
Co-authored papers 2
Alan Keith Dunker
Center for Computational Biology, Indiana University School of Medicine
Co-authored papers 2
Michele Vendruscolo
University of Cambridge
Co-authored papers 2
Jeffrey A Toretsky
Georgetown University Medical Center, Georgetown University
Co-authored papers 2
Paul C Driscoll
The Francis Crick Institute
Co-authored papers 2
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 2
Maria Sunnerhagen
Linkoping University
Co-authored papers 2
David T Jones
University College London
Co-authored papers 2
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 1
Lu-Yun Lian
Institute of Systems, The University of Liverpool
Co-authored papers 1
Christian R H Raetz
Co-authored papers 1
Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Burkhard Rost
Technical University of Munich (TUM)
Co-authored papers 1
Ad Bax
National Institutes of Health
Co-authored papers 1
Release 1.2