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Author Details

Charles Natanson
Clinical Center, National Institutes of Health
1984
164
51
PMIDPaper TitleJournal TitlePublished Year
37615179Controls, comparator arms, and designs for critical care comparative effectiveness research: It's complicated.Clin Trials2024
38045594Modeling current practices in critical care comparative effectiveness research.Crit Care Resusc2023
33989079Mechanistic insights into cell-free hemoglobin-induced injury during septic shock.Am J Physiol Heart Circ Physiol2021
32332282Individualized Care Is Superior to Standardized Care for the Majority of Critically Ill Patients.Crit Care Med2020
31910138Response to Open Peer Commentaries on "Misrepresenting 'Usual Care' in Research: An Ethical and Scientific Error".Am J Bioeth2020
31896328Misrepresenting "Usual Care" in Research: An Ethical and Scientific Error.Am J Bioeth2020
32389103Comparative effectiveness research in critically ill patients: risks associated with mischaracterising usual care.Crit Care Resusc2020
32148923Driving blind: instituting SEP-1 without high quality outcomes data.J Thorac Dis2020
30383305Impact of different standard red blood cell storage temperatures on human and canine RBC hemolysis and chromium survival.Transfusion2019
31639229Haptoglobin therapy has differential effects depending on severity of canine septic shock and cell-free hemoglobin level.Transfusion2019
31299340Inhaled nebulized nitrite and nitrate therapy in a canine model of hypoxia-induced pulmonary hypertension.Nitric Oxide2019
31369426Antibiotic- and Fluid-Focused Bundles Potentially Improve Sepsis Management, but High-Quality Evidence Is Lacking for the Specificity Required in the Centers for Medicare and Medicaid Service's Sepsis Bundle (SEP-1).Crit Care Med2019
29243830Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016.Transfusion2018
30232287Haptoglobin improves shock, lung injury, and survival in canine pneumonia.JCI Insight2018
29675833Risks of restrictive red blood cell transfusion strategies in patients with cardiovascular disease (CVD): a meta-analysis.Transfus Med2018
29475872Endorsing performance measures is a matter of trust.BMJ2018
29543952Evidence Underpinning the Centers for Medicare & Medicaid Services' Severe Sepsis and Septic Shock Management Bundle (SEP-1).Ann Intern Med2018
29459977Evidence Underpinning the Centers for Medicare & Medicaid Services' Severe Sepsis and Septic Shock Management Bundle (SEP-1): A Systematic Review.Ann Intern Med2018
28656646Parenteral irons versus transfused red blood cells for treatment of anemia during canine experimental bacterial pneumonia.Transfusion2017
26974447Measuring Impact: Citation Rates and the Quest to Identify Meaningful Clinical Research in Critical Care Medicine.Crit Care Med2016
27191961Usual Care and Informed Consent in Clinical Trials of Oxygen Management in Extremely Premature Infants.PLoS One2016
26848822Transfusion of recently donated (fresh) red blood cells (RBCs) does not improve survival in comparison with current practice, while safety of the oldest stored units is yet to be established: a meta-analysis.Vox Sang2016
25993950Clinical practice: Blood-transfusion decisions not simple.Nature2015
29805474Transfusion of fresh vs. older red blood cells in the context of infection.ISBT Sci Ser2015
26355383Red Blood Cell Transfusion: Precision vs Imprecision Medicine.JAMA2015
26469998In a canine pneumonia model of exchange transfusion, altering the age but not the volume of older red blood cells markedly alters outcome.Transfusion2015
26176391More on the Age of Transfused Red Cells.N Engl J Med2015
26175134Transfused older stored red blood cells improve the clinical course and outcome in a canine lethal hemorrhage and reperfusion model.Transfusion2015
25888156The influence of the storage lesion(s) on pediatric red cell transfusion.Curr Opin Pediatr2015
24460532Does prolonged storage of red blood cells cause harm?Br J Haematol2014
25294215Hypothalamic-pituitary-adrenal axis in lethal canine Staphylococcus aureus pneumonia.Am J Physiol Endocrinol Metab2014
25385352Concerns over use of hydroxyethyl starch solutions.BMJ2014
25098333Tidal volume and plateau pressure use for acute lung injury from 2000 to present: a systematic literature review.Crit Care Med2014
24588210Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia.Transfusion2014
24618973Mortality in patients with hypovolemic shock treated with colloids or crystalloids.JAMA2014
24366359Washing older blood units before transfusion reduces plasma iron and improves outcomes in experimental canine pneumonia.Blood2014
23255558Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia.Blood2013
23887234Antitumor necrosis factor therapy is associated with improved survival in clinical sepsis trials: a meta-analysis.Crit Care Med2013
23488474In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines.Transfusion2013
21926575Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock.Crit Care Med2012
23231676In reply to "Transfusion of older blood and risk of death: unanswered questions".Transfusion2012
23165669Red blood cell transfusion.Ann Intern Med2012
23111805Beneficial effects of stress-dose corticosteroid therapy in canines depend on the severity of staphylococcal pneumonia.Intensive Care Med2012
23099417Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin.Free Radic Biol Med2012
22790311Systematic analysis of hydroxyethyl starch (HES) reviews: proliferation of low-quality reviews overwhelms the results of well-performed meta-analyses.Intensive Care Med2012
22467668Excess deaths associated with tigecycline after approval based on noninferiority trials.Clin Infect Dis2012
22188419Transfusion of older stored blood and risk of death: a meta-analysis.Transfusion2012
21323610Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies.Expert Opin Drug Metab Toxicol2011
21961576The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death.Expert Opin Investig Drugs2011
19820238Practice misalignments in randomized controlled trials: Identification, impact, and potential solutions.Anesth Analg2010
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Collaborators

Harvey G Klein
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Co-authored papers 28
Mark T Gladwin
University of Maryland School of Medicine
Co-authored papers 10
Kenneth E Remy
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Co-authored papers 8
Margaret M Parker
Co-authored papers 7
Jonathan E Sevransky
Emory University
Co-authored papers 6
Judith Welsh
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Co-authored papers 6
Michael A Solomon
Clinical Center/Critical Care Medicine Department, National Institutes of Health
Co-authored papers 6
Tamir Kanias
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Co-authored papers 5
Andre C Kalil
University of Nebraska School of Medicine
Co-authored papers 3
Caitlin W Hicks
The Johns Hopkins Hospital
Co-authored papers 3
Christiane S Hartog
Charite Universitatsmedizin Berlin
Co-authored papers 3
Mitchell P Fink
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Co-authored papers 2
Martha Quezado
National Cancer Institute (NCI), National Institutes of Health (NIH)
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Vitalant Research Institute
Co-authored papers 1
John R Hess
Harborview Medical Center
Co-authored papers 1
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Duke University Health System
Co-authored papers 1
Marcos Intaglietta
University of California
Co-authored papers 1
Philip C Spinella
Pittsburgh University
Co-authored papers 1
Linda C Cork
Co-authored papers 1
Kevin P Blaine
Oregon Health & Science University
Co-authored papers 1
Philip J Norris
Vitalant Research Institute
Co-authored papers 1
Saixia Ying
Yunnan University of Chinese Medicine
Co-authored papers 1
Michael A Dubick
United States Army Institute of Surgical Research
Co-authored papers 1
Paul M Ness
Johns Hopkins University
Co-authored papers 1
Harold M Swartz
Dartmouth College, New Hampshire Geisel School of Medicine
Co-authored papers 1
Bernhard O Palsson
University of California San Diego
Co-authored papers 1
Simone A Glynn
Clinical Sciences
Co-authored papers 1
Thomas Hartung
University of Konstanz
Co-authored papers 1
Peter J Munson
and Blood Institute, National Institutes of Health
Co-authored papers 1
Henry Clifford Lane
Division of Clinical Research, National Institutes of Allergy and Infectious Diseases
Co-authored papers 1
Release 1.2