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Author Details

Ulrich Broeckel
Medical College of Wisconsin
1998
124
43
PMIDPaper TitleJournal TitlePublished Year
36828597Multisite Assessment of Optical Genome Mapping for Analysis of Structural Variants in Constitutional Postnatal Cases.J Mol Diagn2023
38028628Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.Front Genet2023
37354993Characterization of Reference Materials for CYP3A4 and CYP3A5: A (GeT-RM) Collaborative Project.J Mol Diagn2023
37419294Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds.J Pharmacol Toxicol Methods2023
37426826Characterization of complex structural variation in the <i>CYP2D6-CYP2D7-CYP2D8</i> gene loci using single-molecule long-read sequencing.Front Pharmacol2023
34693927Incorporating G6PD genotyping to identify patients with G6PD deficiency.Pharmacogenet Genomics2022
35931342Characterization of Reference Materials for TPMT and NUDT15: A GeT-RM Collaborative Project.J Mol Diagn2022
36294714Characterization of Novel <i>CYP2D6</i> Alleles across Sub-Saharan African Populations.J Pers Med2022
33416449Donor-specific phenotypic variation in hiPSC cardiomyocyte-derived exosomes impacts endothelial cell function.Am J Physiol Heart Circ Physiol2021
33713608Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry.Am J Hum Genet2021
33679876Whole-Exome Sequencing and hiPSC Cardiomyocyte Models Identify <i>MYRIP</i>, <i>TRAPPC11</i>, and <i>SLC27A6</i> of Potential Importance to Left Ventricular Hypertrophy in an African Ancestry Population.Front Genet2021
33631352Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization.J Mol Diagn2021
34387095Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop.Circ Cardiovasc Imaging2021
34020041Characterization of Reference Materials with an Association for Molecular Pathology Pharmacogenetics Working Group Tier 2 Status: CYP2C9, CYP2C19, VKORC1, CYP2C Cluster Variant, and GGCX: A GeT-RM Collaborative Project.J Mol Diagn2021
34283790Personal DNA Testing Increases Pharmacy Students' Confidence and Competence in Pharmacogenomics.Am J Pharm Educ2021
31341243Challenges in clinical implementation of CYP2D6 genotyping: choice of variants to test affects phenotype determination.Genet Med2020
32652930Detecting fitness epistasis in recently admixed populations with genome-wide data.BMC Genomics2020
32442913Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program.Stem Cell Res2020
29737521Age- and Genotype-Dependent Variability in the Protein Abundance and Activity of Six Major Uridine Diphosphate-Glucuronosyltransferases in Human Liver.Clin Pharmacol Ther2019
30045819Clinical correlates and heritability of cardiac mechanics: The HyperGEN study.Int J Cardiol2019
30206300Concordance between glucose-6-phosphate dehydrogenase (G6PD) genotype and phenotype and rasburicase use in patients with hematologic malignancies.Pharmacogenomics J2019
31401124Characterization of Reference Materials for Genetic Testing of CYP2D6 Alleles: A GeT-RM Collaborative Project.J Mol Diagn2019
31127295A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure.Hum Mol Genet2019
30643267Thymic regulatory T cells arise via two distinct developmental programs.Nat Immunol2019
30686581A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling.Cell2019
29599514Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator.Genes Immun2019
29455858A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.Am J Hum Genet2018
29912962Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.PLoS One2018
29602798Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.Drug Metab Dispos2018
27917522Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome.Genet Epidemiol2017
28302652The <i>ENTPD1</i> promoter polymorphism -860 A &gt; G (rs3814159) is associated with increased gene transcription, protein expression, CD39/NTPDase1 enzymatic activity, and thromboembolism risk.FASEB J2017
28394258Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function.J Clin Invest2017
29503979Whole exome analyses to examine the impact of rare variants on left ventricular traits in African American participants from the HyperGEN and GENOA studies.J Hypertens Manag2017
29133930PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development.Nat Commun2017
28819071Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver.J Pharmacol Exp Ther2017
27967321The impact of the UGT1A1*60 allele on bilirubin serum concentrations.Pharmacogenomics2017
26915630Incorporating a Genetic Risk Score Into Coronary Heart Disease Risk Estimates: Effect on Low-Density Lipoprotein Cholesterol Levels (the MI-GENES Clinical Trial).Circulation2016
26621101Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.J Mol Diagn2016
27588742What Can hiPSC-Cardiomyocytes Teach Us about Modeling Complex Human Disease Phenotypes?Cell Stem Cell2016
27549580Concomitant 11p15.4-p15.5 duplication and terminal 22q13.33 deletion in a patient with features of Beckwith-Wiedemann syndrome.Am J Med Genet A2016
27311679Comparison of genome sequencing and clinical genotyping for pharmacogenes.Clin Pharmacol Ther2016
27335380Pharmacogenetics for Safe Codeine Use in Sickle Cell Disease.Pediatrics2016
25348728Whole exome sequencing identifies a POLRID mutation segregating in a father and two daughters with findings of Klippel-Feil and Treacher Collins syndromes.Am J Med Genet A2015
26621740The introduction of RNA-DNA differences underlies interindividual variation in the human IL12RB1 mRNA repertoire.Proc Natl Acad Sci U S A2015
26673413Comprehensive evaluation of AmpliSeq transcriptome, a novel targeted whole transcriptome RNA sequencing methodology for global gene expression analysis.BMC Genomics2015
26131930Directional dominance on stature and cognition in diverse human populations.Nature2015
25904937PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies.Front Genet2015
25292429Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers.Annu Rev Pharmacol Toxicol2015
23978487Development and use of active clinical decision support for preemptive pharmacogenomics.J Am Med Inform Assoc2014
25255322RNA expression profiling of human iPSC-derived cardiomyocytes in a cardiac hypertrophy model.PLoS One2014
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Collaborators

Co-authored papers 32
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Departments of Pharmaceutical Sciences.
Co-authored papers 14
School of Public Health, University of Michigan ann arbor
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St. Jude Children's Research Hospital
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National Institute on Aging
Co-authored papers 11
Loyola University Chicago
Co-authored papers 10
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Genomics Research Center
Co-authored papers 10
University of Alabama at Birmingham
Co-authored papers 10
University of Alabama at Birmingham School of Public Health
Co-authored papers 10
Co-authored papers 9
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Co-authored papers 9
Center for Alzheimer's and Related Dementias, National Institutes of Health
Co-authored papers 9
Loyola University Medical Center.
Co-authored papers 9
National Institute on Aging
Co-authored papers 9
National Institute on Aging
Co-authored papers 9
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Departments of Oncology. St. Jude Children's Research Hospital
Co-authored papers 8
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School of Public Health, University of Michigan ann arbor
Co-authored papers 8