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Author Details

Henry W Querfurth
Tufts Medical Center and Neuroscience, Tufts University
1987
49
28
PMIDPaper TitleJournal TitlePublished Year
36933140Clinical and Scientific Challenges to Effectiveness Studies Under Coverage with Evidence Development in Alzheimer's Disease.Neurol Ther2023
36404570A PDK-1 allosteric agonist improves spatial learning and memory in a βAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer's disease.Behav Brain Res2023
35061720A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro.PLoS One2022
34215308Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration.Mol Neurodegener2021
32903821mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration.Front Neurosci2020
29739726New onset seizures in a patient with Long QT Syndrome (LQTS2) and a pathogenic carboxyl-terminus frameshift variant of the KCNH2 gene.J Clin Neurosci2018
28035937mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons.J Alzheimers Dis2017
26968811Increased amyloid β-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy.Oncotarget2016
26881156Cognitive Impairments Preceding and Outlasting Autoimmune Limbic Encephalitis.Case Rep Neurol Med2016
26022371Synergistic effects of β-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells.Biochim Biophys Acta2015
26344902Palmitate activates mTOR/p70S6K through AMPK inhibition and hypophosphorylation of raptor in skeletal muscle cells: Reversal by oleate is similar to metformin.Biochimie2015
24556217Aberrant cell cycle reentry in human and experimental inclusion body myositis and polymyositis.Hum Mol Genet2014
25161767The injury-induced myokine insulin-like 6 is protective in experimental autoimmune myositis.Skelet Muscle2014
24732014Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells.Biochim Biophys Acta2014
24027495Multiple effects of β-amyloid on single excitatory synaptic connections in the PFC.Front Cell Neurosci2013
22098618Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.J Neurochem2012
22590725Foxo/atrogin induction in human and experimental myositis.Neurobiol Dis2012
22343285Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.Proc Natl Acad Sci U S A2012
19108934Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle.Neurobiol Aging2010
21040572Ophthalmodynamometry for ICP prediction and pilot test on Mt. Everest.BMC Neurol2010
20107219Alzheimer's disease.N Engl J Med2010
19610108Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.J Neurosci Res2010
19144826The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid.Mol Biol Cell2009
20027222Opposite effects of low and high doses of Abeta42 on electrical network and neuronal excitability in the rat prefrontal cortex.PLoS One2009
19483198Parkin promotes intracellular Abeta1-42 clearance.Hum Mol Genet2009
18021291Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice.J Neurochem2008
17317785CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.Hum Mol Genet2007
15950323Pathogenic accumulation of APP in fast twitch muscle of IBM patients and a transgenic model.Neurobiol Aging2006
16940437Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology.FASEB J2006
16887805Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis.J Biol Chem2006
16517603Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells.J Biol Chem2006
16427623Dissociation of ERK and Akt signaling in endothelial cell angiogenic responses to beta-amyloid.Exp Cell Res2006
16306409Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response.J Neurosci2005
14744296Cavernous sinus and leptomeningeal metastases arising from a squamous cell carcinoma of the face: case report.Neurosurgery2004
16174913Prediction of intracranial pressure from noninvasive transocular venous and arterial hemodynamic measurements: a pilot study.Neurocrit Care2004
15385569Calcium dyshomeostasis in beta-amyloid and tau-bearing skeletal myotubes.J Biol Chem2004
14973234Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.J Neurosci2004
12781990Downregulation and increased turnover of beta-amyloid precursor protein in skeletal muscle cultures by neuregulin-1.Exp Neurol2003
12600720Abeta42 generation is toxic to endothelial cells and inhibits eNOS function through an Akt/GSK-3beta signaling-dependent mechanism.Neurobiol Aging2003
12027831Flow velocity and pulsatility of the ocular circulation in chronic intracranial hypertension.Acta Neurol Scand2002
11358479Beta-amyloid peptide expression is sufficient for myotube death: implications for human inclusion body myopathy.Mol Cell Neurosci2001
11044776Acetylcholinesterase inhibition in dementia with Lewy bodies: results of a prospective pilot trial.Dement Geriatr Cogn Disord2000
10333529Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter.Gene1999
9693105Expression of ryanodine receptors in human embryonic kidney (HEK293) cells.Biochem J1998
9326287Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells.J Neurochem1997
7723630Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family.Brain Res Mol Brain Res1995
8161510Calcium ionophore increases amyloid beta peptide production by cultured cells.Biochemistry1994
2185721Vaccine-associated paralytic poliomyelitis. Regional case series and review.Arch Neurol1990
2439662Sodium channels in normal and regenerated feline ventral spinal roots.J Neurosci1987
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Collaborators

Kenneth Walsh
University of Virginia School of Medicine
Co-authored papers 8
Paul D Allen
Leeds Institute of Medical Research, University of Leeds
Co-authored papers 2
Robert Bartha
The University of Western Ontario
Co-authored papers 1
Stephen Salloway
Butler Hospital, and Warren Alpert Medical School of Brown University
Co-authored papers 1
Paul F Malloy
Warren Alpert Medical School of Brown University
Co-authored papers 1
Peggy Roberts
Co-authored papers 1
Janet Cellar
Integrated Memory Care Clinic
Co-authored papers 1
Martin R Farlow
Stark Neurosciences Research Institute, Indiana University School of Medicine (IUSM)
Co-authored papers 1
Richard E Carson
Yale University
Co-authored papers 1
Keith A Johnson
Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1
Leon Hudson
Wayne State University School of Medicine and College of Nursing
Co-authored papers 1
Bj Casey
Barnard College of Columbia University
Co-authored papers 1
Lawrence S Honig
University of California
Co-authored papers 1
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Washington University School of Medicine
Co-authored papers 1
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University of Pittsburgh
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David Geffen School of Medicine at University of California-Los Angeles
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Hilda Rizzo-Busack
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Ranjan Duara
Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center
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Dana Mathews
University of Texas Southwestern Medical Center
Co-authored papers 1
Nancy Johnson
Northwestern University Feinberg School of Medicine
Co-authored papers 1
Sandra A Jacobson
University of Arizona College of Medicine
Co-authored papers 1
Smita Kittur
SUNY Upstate Medical University
Co-authored papers 1
Andrew J Saykin
Indiana University School of Medicine
Co-authored papers 1
Richard Frank
Siemens Healthineers North America, Siemens Medical Solutions USA
Co-authored papers 1
Ging-Yuek
Co-authored papers 1
Danielle Harvey
University of California davis
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Rachelle S Doody
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Tal Kenet
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Release 1.2