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Author Details

Colin T Shearn
University of Colorado School of Medicine
2001
53
21
PMIDPaper TitleJournal TitlePublished Year
36633484Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury.Hepatol Commun2023
37647292Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition.PLoS One2023
37398356Endocrine pancreas-specific <i>Gclc</i> gene deletion causes a severe diabetes phenotype.bioRxiv2023
34387888Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice.Hepatology2022
36378690The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease.PLoS One2022
33004979Bile acids modulate colonic MAdCAM-1 expression in a murine model of combined cholestasis and colitis.Mucosal Immunol2021
33673577Supplemental Ascorbate Diminishes DNA Damage Yet Depletes Glutathione and Increases Acute Liver Failure in a Mouse Model of Hepatic Antioxidant System Disruption.Antioxidants (Basel)2021
33693819Identification of Dose-Dependent DNA Damage and Repair Responses From Subchronic Exposure to 1,4-Dioxane in Mice Using a Systems Analysis Approach.Toxicol Sci2021
34310734NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis.Hepatology2021
33277360Multivalent lipid targeting by the calcium-independent C2A domain of synaptotagmin-like protein 4/granuphilin.J Biol Chem2021
326283204-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.J Cell Biochem2020
30644754Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.J Proteome Res2019
31377417Cholestatic liver disease results increased production of reactive aldehydes and an atypical periportal hepatic antioxidant response.Free Radic Biol Med2019
31263795Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.Curr Opin Toxicol2019
31097586TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.Proc Natl Acad Sci U S A2019
29101223Taurine treatment prevents derangement of the hepatic γ-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism.FASEB J2018
29799837Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice.PLoS One2018
29852184Aberrant expression of redox regulatory proteins in patients with concomitant primary Sclerosing cholangitis/inflammatory bowel disease.Exp Mol Pathol2018
29587455Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.Biomolecules2018
29708596Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.Alcohol Clin Exp Res2018
29180269Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease.Exp Mol Pathol2018
27998724Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis.Am J Pathol2017
28988798Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH.Free Radic Biol Med2017
28804911Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.Alcohol Clin Exp Res2017
28658624Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase.Cell Rep2017
27468209Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury.World J Gastroenterol2016
26654979Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.Redox Biol2016
27124661Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.PLoS One2016
27501738Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease.J Hepatol2016
25427907Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma.Adv Exp Med Biol2015
26518673Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis.Free Radic Biol Med2015
26177469Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney.Redox Biol2015
25501545Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease.Am J Physiol Gastrointest Liver Physiol2015
24722988Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol.J Biol Chem2014
24818992Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice.PLoS One2014
24924946Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.Free Radic Biol Med2014
23359610Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver.J Lipid Res2013
23872024Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis.Free Radic Biol Med2013
23836899Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor α (ERRα).J Biol Chem2013
23465594Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis.J Nutr Biochem2013
22580126Inhibition of hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells.Free Radic Biol Med2012
22701647Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics.PLoS One2012
22829816Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease.J Toxicol2012
21415306Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes.Mol Pharmacol2011
21536018Protein damage from electrophiles and oxidants in lungs of mice chronically exposed to the tumor promoter butylated hydroxytoluene.Chem Biol Interact2011
21319786Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion.J Proteome Res2011
21438592Modification of Akt2 by 4-hydroxynonenal inhibits insulin-dependent Akt signaling in HepG2 cells.Biochemistry2011
214495654-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.Chem Res Toxicol2011
20399851Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis.Free Radic Biol Med2010
20111671Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model.J Herbs Spices Med Plants2009
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Collaborators

David J Orlicky
University of Colorado School of Medicine
Co-authored papers 30
Ronald J Sokol
Digestive Health Institute, Children's Hospital Colorado
Co-authored papers 6
Aimee L Anderson
University of Colorado School of Medicine
Co-authored papers 5
Michael W Devereaux
University of Colorado School of Medicine
Co-authored papers 4
Karim C El Kasmi
Boehringer Ingelheim Pharma GmbH & Co. KG
Co-authored papers 3
Swati Ghosh
University of Colorado School of Medicine
Co-authored papers 2
Angelo D'Alessandro
University of Colorado Anschutz Medical Campus
Co-authored papers 2
Matthew D Hirschey
Duke Molecular Physiology Institute, Duke University School of Medicine
Co-authored papers 2
Ariel E Feldstein
University of California San Diego
Co-authored papers 1
Lawrence E Hunter
University of Colorado School of Medicine
Co-authored papers 1
Mark A Lovell
University of Kentucky
Co-authored papers 1
Sarah Gehrke
University of Colorado Anschutz Medical Campus
Co-authored papers 1
Michael P Kavanaugh
University of Montana.
Co-authored papers 1
Nicholas O Davidson
Co-authored papers 1
Julie A Reisz
University of Colorado Anschutz Medical Campus
Co-authored papers 1
Sanjiv Harpavat
Baylor College of Medicine
Co-authored papers 1
Nicholas J W Rattray
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
Co-authored papers 1
Daniel W Nebert
Co-authored papers 1
Caroline H Johnson
Yale School of Public Health
Co-authored papers 1
Release 1.2