Skip to Main Content

Author Details

Edward J Hennessy
Oncology R&D
2002
22
14
PMIDPaper TitleJournal TitlePublished Year
37343272Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.J Med Chem2023
34478292Optimization of an Imidazo[1,2-<i>a</i>]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with <i>In Vivo</i> Efficacy.J Med Chem2021
33683117Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.J Med Chem2021
33495510Design and optimisation of dendrimer-conjugated Bcl-2/x<sub>L</sub> inhibitor, AZD0466, with improved therapeutic index for cancer therapy.Commun Biol2021
32988967AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x<sub>L</sub>, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia.Clin Cancer Res2020
31531204Structural and Molecular Insight into Resistance Mechanisms of First Generation cMET Inhibitors.ACS Med Chem Lett2019
26988306Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity.Bioorg Med Chem Lett2016
27994749Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.ACS Med Chem Lett2016
27190603Utilization of Structure-Based Design to Identify Novel, Irreversible Inhibitors of EGFR Harboring the T790M Mutation.ACS Med Chem Lett2016
25980951Small molecule inhibitor of apoptosis proteins antagonists: a patent review.Expert Opin Ther Pat2015
26291341Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.J Med Chem2015
25890801Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists.Bioorg Med Chem Lett2015
24631189Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.Bioorg Med Chem Lett2014
25458601Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.J Med Chem2014
23398453Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.J Med Chem2013
24320998Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).J Med Chem2013
22264476Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.Bioorg Med Chem Lett2012
18480256Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs.Proc Natl Acad Sci U S A2008
16122261Synthesis of 4,5-dianilinophthalimide and related analogues for potential treatment of Alzheimer's disease via palladium-catalyzed amination.J Org Chem2005
14518981Synthesis of substituted oxindoles from alpha-chloroacetanilides via palladium-catalyzed C[bond]H functionalization.J Am Chem Soc2003
14510571trans-Cyclopropyl beta-amino acid derivatives via asymmetric cyclopropanation using a (Salen)Ru(II) catalyst.J Org Chem2003
11796067A general and mild copper-catalyzed arylation of diethyl malonate.Org Lett2002
  • 1 - 22 of 22

Recommended Authors

Jiankun Lyu
Department of Pharmaceutical Chemistry, University of California san francisco
Career Start Year 2015
Number of shared co-authors 0
Phillip P Sharp
University of California san francisco
Career Start Year 2013
Number of shared co-authors 0
Ahmed Aman
Ontario Institute for Cancer Research, University Avenue
Career Start Year 2007
Number of shared co-authors 0
Kevin Lou
Howard Hughes Medical Institute, University of California san francisco
Career Start Year 2007
Number of shared co-authors 0
Priyadarshini Jaishankar
Department of Pharmaceutical Chemistry, University of California san francisco
Career Start Year 2005
Number of shared co-authors 0
Carlota Lopez Cara
Department of Pharmaceutical and Organic Chemistry, University of Granada
Career Start Year 2005
Number of shared co-authors 0
Xiaoguang Lei
Peking-Tsinghua Center for Life Sciences, Peking University
Career Start Year 2003
Number of shared co-authors 0
Anang A Shelat
St. Jude Children's Research Hospital
Career Start Year 2003
Number of shared co-authors 0
Noel Southall
National Center for Advancing Translational Sciences, National Institutes of Health
Career Start Year 2002
Number of shared co-authors 0
Brian R Hearn
Department of Pharmaceutical Chemistry and, University of California san francisco
Career Start Year 2002
Number of shared co-authors 0
Michael Prakesch
Ontario Institute for Cancer Research, University Avenue
Career Start Year 2001
Number of shared co-authors 0
Craig J Thomas
Center for Cancer Research, National Cancer Institute
Career Start Year 2001
Number of shared co-authors 1
Anthony B Pinkerton
Sanford Burnham Prebys Medical Discovery Institute
Career Start Year 2000
Number of shared co-authors 1
Rima Al-Awar
Ontario Institute for Cancer Research, University Avenue
Career Start Year 1999
Number of shared co-authors 0
Jian Jin
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Career Start Year 1998
Number of shared co-authors 0
Fei Liu
Macquarie University
Career Start Year 1998
Number of shared co-authors 0
Sharad K Verma
Johns Hopkins University
Career Start Year 1998
Number of shared co-authors 0
Anne Marinier
Institute for Research in Immunology and Cancer
Career Start Year 1997
Number of shared co-authors 0
Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Career Start Year 1997
Number of shared co-authors 0
Methvin Isaac
Ontario Institute for Cancer Research, University Avenue
Career Start Year 1997
Number of shared co-authors 0
Nathanael S Gray
Harvard Medical School
Career Start Year 1996
Number of shared co-authors 8
Paul J Hergenrother
University of Illinois at Urbana-Champaign
Career Start Year 1995
Number of shared co-authors 0
Michael Ohlmeyer
Atux Iskay LLC
Career Start Year 1993
Number of shared co-authors 3
Sutapa Ghosh
The State University of New Jersey
Career Start Year 1993
Number of shared co-authors 0
Timothy A Lewis
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Career Start Year 1990
Number of shared co-authors 0
David Uehling
Ontario Institute for Cancer Research, University Avenue
Career Start Year 1989
Number of shared co-authors 0
Sally Freeman
Division of Pharmacy and Optometry, University of Manchester
Career Start Year 1988
Number of shared co-authors 0
Joel Morris
National Cancer Institute
Career Start Year 1986
Number of shared co-authors 0
Robert J Ardecky
Sanford Burnham Prebys Medical Discovery Institute
Career Start Year 1985
Number of shared co-authors 1
Stuart L Schreiber
Broad Institute
Career Start Year 1985
Number of shared co-authors 1

Collaborators

Jamal C Saeh
Oncology R&D
Co-authored papers 7
William McCoull
Oncology R&D
Co-authored papers 5
Ammar Adam
Oncology R&D
Co-authored papers 4
Shenghua Wen
Oncology R&D
Co-authored papers 3
Terry MacIntyre
Oncology R&D
Co-authored papers 3
Kate F Byth
Oncology R&D
Co-authored papers 3
Justin Cidado
Oncology R&D
Co-authored papers 2
J Paul Secrist
Oncology R&D
Co-authored papers 2
Francis D Gibbons
Preclinical and Translational Sciences, Inc.
Co-authored papers 2
Barry R Davies
Oncology R&D
Co-authored papers 2
Jeffrey G Varnes
Oncology R&D
Co-authored papers 2
Eric Gangl
Oncology R&D
Co-authored papers 2
Martin Wild
Oncology R&D
Co-authored papers 2
Stephen Fawell
Oncology R&D
Co-authored papers 2
Alwin G Schuller
Oncology R&D
Co-authored papers 2
Nancy Su
Co-authored papers 2
Paula Lewis
Oncology R&D
Co-authored papers 2
Gareth P Gregory
School of Clinical Sciences at Monash Health, Monash University
Co-authored papers 1
Deborah Lawson
Oncology R&D
Co-authored papers 1
Peter R Weigele
New England Biolabs Inc.
Co-authored papers 1
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 1
Susan Lindquist
Whitehead Institute for Biomedical Research
Co-authored papers 1
Patricia Jaaks
Wellcome Sanger Institute
Co-authored papers 1
Lucienne Ronco
Co-authored papers 1
Stephanos Ioannidis
H3 Biomedicine Inc.
Co-authored papers 1
Steven W Criscione
Oncology R&D
Co-authored papers 1
Kathleen Burke
Oncology R&D
Co-authored papers 1
Ricky W Johnstone
The University of Melbourne
Co-authored papers 1
Areya Tabatabai
Oncology R&D
Co-authored papers 1
Andrea Newbold
Peter MacCallum Cancer Centre
Co-authored papers 1
Release 1.2