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Author Details

Kevin G Hardwick
Institute of Cell Biology, University of Edinburgh
1988
62
36
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37279667Cell-cycle control: Timing is everything for the Plk1-Bub1 partnership.Curr Biol2023
31257143The Bub1-TPR Domain Interacts Directly with Mad3 to Generate Robust Spindle Checkpoint Arrest.Curr Biol2019
30237224Regulated reconstitution of spindle checkpoint arrest and silencing through chemically induced dimerisation <i>in vivo</i>.J Cell Sci2018
28017606Generation of a Spindle Checkpoint Arrest from Synthetic Signaling Assemblies.Curr Biol2017
28178520Identification of a Sgo2-Dependent but Mad2-Independent Pathway Controlling Anaphase Onset in Fission Yeast.Cell Rep2017
28366744Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest.Curr Biol2017
27101248Correction: Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.PLoS Genet2016
26882497Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.PLoS Genet2016
25619765The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.Curr Biol2015
24565511Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.Cell Rep2014
25306921Dss1 is a 26S proteasome ubiquitin receptor.Mol Cell2014
24945319CPF-associated phosphatase activity opposes condensin-mediated chromosome condensation.PLoS Genet2014
23804033Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1.Nat Commun2013
22281223Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.Curr Biol2012
22521786Phosphodependent recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 kinase maintains the spindle checkpoint.Curr Biol2012
21664573Spindle checkpoint silencing requires association of PP1 to both Spc7 and kinesin-8 motors.Dev Cell2011
21965289Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.Mol Biol Cell2011
19836959Getting down to the phosphorylated 'nuts and bolts' of spindle checkpoint signalling.Trends Biochem Sci2010
21173869Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset.F1000 Biol Rep2010
19475393The spindle checkpoint: assays for the analysis of spindle checkpoint arrest and recovery.Methods Mol Biol2009
19846658Bub3p facilitates spindle checkpoint silencing in fission yeast.Mol Biol Cell2009
19915592An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.Nat Struct Mol Biol2009
20008930Overcoming inhibition in the spindle checkpoint.Genes Dev2009
19592249A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism.Curr Biol2009
18368927The spindle checkpoint: how do cells delay anaphase onset?SEB Exp Biol Ser2008
18556659The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).J Biol Chem2008
17392514Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function.Mol Biol Cell2007
18094750Bub1 is a fission yeast kinetochore scaffold protein, and is sufficient to recruit other spindle checkpoint proteins to ectopic sites on chromosomes.PLoS One2007
18081426Bub1 kinase targets Sgo1 to ensure efficient chromosome biorientation in budding yeast mitosis.PLoS Genet2007
17301288Shugoshin 2 regulates localization of the chromosomal passenger proteins in fission yeast mitosis.Mol Biol Cell2007
17510347Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".Science2007
17406666Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint.PLoS One2007
17504936Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.Genes Dev2007
17038540The spindle checkpoint.J Cell Sci2006
15723780Checkpoint signalling: Mad2 conformers and signal propagation.Curr Biol2005
16360688Control of Shugoshin function during fission-yeast meiosis.Curr Biol2005
15866025Bub1 and the multilayered inhibition of Cdc20-APC/C in mitosis.Trends Cell Biol2005
15525673The A78V mutation in the Mad3-like domain of Schizosaccharomyces pombe Bub1p perturbs nuclear accumulation and kinetochore targeting of Bub1p, Bub3p, and Mad3p and spindle assembly checkpoint function.Mol Biol Cell2005
15509783Kinetochore targeting of fission yeast Mad and Bub proteins is essential for spindle checkpoint function but not for all chromosome segregation roles of Bub1p.Mol Cell Biol2004
12538762Analysis of Bub3 spindle checkpoint function in Xenopus egg extracts.J Cell Sci2003
12695661The complexity of Bub1 regulation--phosphorylation, phosphorylation, phosphorylation.Cell Cycle2003
11909965Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p-, and Mph1p-dependent manner.Mol Cell Biol2002
12221113Distinct chromosome segregation roles for spindle checkpoint proteins.Mol Biol Cell2002
12360190The spindle checkpoint: structural insights into dynamic signalling.Nat Rev Mol Cell Biol2002
12062159The awesome power of multiple model systems: interpreting the complex nature of spindle checkpoint signaling.Trends Cell Biol2002
10704439MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.J Cell Biol2000
10837255Complex formation between Mad1p, Bub1p and Bub3p is crucial for spindle checkpoint function.Curr Biol2000
10871278Cdc28 activates exit from mitosis in budding yeast.J Cell Biol2000
10436016The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins.Mol Biol Cell1999
10353895Lesions in many different spindle components activate the spindle checkpoint in the budding yeast Saccharomyces cerevisiae.Genetics1999
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Co-authored papers 2
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Co-authored papers 2
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Co-authored papers 1
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Co-authored papers 1
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
University of Texas Health
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National Cancer Institute, National Institutes of Health
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University of California davis
Co-authored papers 1
Albert Einstein College of Medicine
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Albert Einstein College of Medicine
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Wellcome Sanger Institute
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Van Andel Institute
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