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Author Details

Robert K Campbell
Serono Research Institute
1990
30
19
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
25283372Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.Chem Biol Drug Des2015
25283372Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.Chem Biol Drug Des2015
25977593Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).Tetrahedron Lett2015
25977593Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).Tetrahedron Lett2015
25127163Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors.Bioorg Med Chem Lett2014
25127163Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors.Bioorg Med Chem Lett2014
24042005Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).Bioorg Med Chem Lett2013
24042005Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1).Bioorg Med Chem Lett2013
22370268Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs.Bioorg Med Chem Lett2012
22377518Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs.Bioorg Med Chem Lett2012
22370268Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs.Bioorg Med Chem Lett2012
22377518Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs.Bioorg Med Chem Lett2012
21859304Target repurposing for neglected diseases.Future Med Chem2011
22023548Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.J Med Chem2011
21859304Target repurposing for neglected diseases.Future Med Chem2011
22023548Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness.J Med Chem2011
18048458Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.Mol Hum Reprod2008
18048458Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.Mol Hum Reprod2008
18927591Genomic-scale prioritization of drug targets: the TDR Targets database.Nat Rev Drug Discov2008
18424034Comparative expression analysis of four breast cancer subtypes versus matched normal tissue from the same patients.J Steroid Biochem Mol Biol2008
18927591Genomic-scale prioritization of drug targets: the TDR Targets database.Nat Rev Drug Discov2008
18424034Comparative expression analysis of four breast cancer subtypes versus matched normal tissue from the same patients.J Steroid Biochem Mol Biol2008
17495128Tumor necrosis factor (TNF)-soluble high-affinity receptor complex as a TNF antagonist.J Pharmacol Exp Ther2007
17495128Tumor necrosis factor (TNF)-soluble high-affinity receptor complex as a TNF antagonist.J Pharmacol Exp Ther2007
16210364Bone morphogenetic protein-15 in the zebrafish ovary: complementary deoxyribonucleic acid cloning, genomic organization, tissue distribution, and role in oocyte maturation.Endocrinology2006
16210364Bone morphogenetic protein-15 in the zebrafish ovary: complementary deoxyribonucleic acid cloning, genomic organization, tissue distribution, and role in oocyte maturation.Endocrinology2006
16021632Main-chain conformational tendencies of amino acids.Proteins2005
16034184Molecular pharmacology of gonadotropins.Endocrine2005
16021632Main-chain conformational tendencies of amino acids.Proteins2005
16110093Myelin tetraspan family proteins but no non-tetraspan family proteins are present in the ascidian (Ciona intestinalis) genome.Biol Bull2005
16034184Molecular pharmacology of gonadotropins.Endocrine2005
16110093Myelin tetraspan family proteins but no non-tetraspan family proteins are present in the ascidian (Ciona intestinalis) genome.Biol Bull2005
15262408Piecing together evolution of the vertebrate endocrine system.Trends Genet2004
27690613Initial Sequence and Protein Modeling Results of a Mitochondrial Genome Project on Understudied Invertebrate Phyla.Biol Bull2004
15262408Piecing together evolution of the vertebrate endocrine system.Trends Genet2004
27690613Initial Sequence and Protein Modeling Results of a Mitochondrial Genome Project on Understudied Invertebrate Phyla.Biol Bull2004
11884080Zebrafish as a model for vertebrate reproduction: characterization of the first functional zebrafish (Danio rerio) gonadotropin receptor.Gen Comp Endocrinol2002
11884080Zebrafish as a model for vertebrate reproduction: characterization of the first functional zebrafish (Danio rerio) gonadotropin receptor.Gen Comp Endocrinol2002
12481130The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins.Science2002
12470813Inferring protein function from genomic sequence: Giardia lamblia expresses a phosphatidylinositol kinase-related kinase similar to yeast and mammalian TOR.Comp Biochem Physiol B Biochem Mol Biol2002
12481130The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins.Science2002
12470813Inferring protein function from genomic sequence: Giardia lamblia expresses a phosphatidylinositol kinase-related kinase similar to yeast and mammalian TOR.Comp Biochem Physiol B Biochem Mol Biol2002
11266609Threading of a glycosylated protein loop through a protein hole: implications for combination of human chorionic gonadotropin subunits.Protein Sci2001
11266609Threading of a glycosylated protein loop through a protein hole: implications for combination of human chorionic gonadotropin subunits.Protein Sci2001
9013570Influence of subunit interactions on lutropin specificity. Implications for studies of glycoprotein hormone function.J Biol Chem1997
9013570Influence of subunit interactions on lutropin specificity. Implications for studies of glycoprotein hormone function.J Biol Chem1997
9131622Chimeric proteins can exceed the sum of their parts: implications for evolution and protein design.Nat Biotechnol1997
9131622Chimeric proteins can exceed the sum of their parts: implications for evolution and protein design.Nat Biotechnol1997
7650019The groove between the alpha- and beta-subunits of hormones with lutropin (LH) activity appears to contact the LH receptor, and its conformation is changed during hormone binding.J Biol Chem1995
7650020Model of human chorionic gonadotropin and lutropin receptor interaction that explains signal transduction of the glycoprotein hormones.J Biol Chem1995
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Collaborators

Co-authored papers 2
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Institute of Integrative Biology, University of Liverpool
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Co-authored papers 1
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University of Massachusetts Medical School
Co-authored papers 1
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CSIR - National Chemical Laboratory
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Peter MacCallum Cancer Centre
Co-authored papers 1
University of Dundee
Co-authored papers 1
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Wellcome Sanger Institute
Co-authored papers 1
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Co-authored papers 1
AGORA Cancer Research Center
Co-authored papers 1
College of Life Sciences, University of Dundee
Co-authored papers 1
Bayer Healthcare Pharmaceuticals
Co-authored papers 1
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
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Lawrence Berkeley National Laboratory
Co-authored papers 1
Pfizer Global Research and Development La Jolla
Co-authored papers 1
Institut fur Biochemie und Molekularbiologie, Universitat Freiburg
Co-authored papers 1
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The Walter and Eliza Hall Institute of Medical Research
Co-authored papers 1
University of Maryland, College Park
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University of Udine
Co-authored papers 1