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Author Details

Sovan Sarkar
CRUK MRC Oxford Institute for Radiation Oncology, University of Oxford
1995
97
51
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36727253Metabolic function of autophagy is essential for cell survival.Autophagy2023
38076943A mitochondrial quality control mechanism reverses the phagosome maturation arrest caused by <i>Mycobacterium tuberculosis</i>.bioRxiv2023
37624702Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons.STAR Protoc2023
37086404NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.Cell Rep2023
37131595DNA damage-induced interaction between a lineage addiction oncogenic transcription factor and the MRN complex shapes a tissue-specific DNA Damage Response and cancer predisposition.bioRxiv2023
37163979Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome.Stem Cell Reports2023
36878731The autophagy-NAD axis in longevity and disease.Trends Cell Biol2023
34490597Autophagy Dysfunction as a Phenotypic Readout in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Diseases.Methods Mol Biol2022
35347693Analysis of Mitochondrial Dysfunction by Microplate Reader in hiPSC-Derived Neuronal Cell Models of Neurodegenerative Disorders.Methods Mol Biol2022
36413951Autophagy promotes cell survival by maintaining NAD levels.Dev Cell2022
33423236Oxygen Consumption Evaluation: An Important Indicator of Metabolic State, Cellular Function, and Cell Fate Along Neural Deregulation.Methods Mol Biol2021
32079455Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block.Autophagy2021
32169483Autophagy in Neurodegenerative Diseases.J Mol Biol2020
32087199Autophagy in Rare (NonLysosomal) Neurodegenerative Diseases.J Mol Biol2020
31998722Editorial: Autophagy: From Big Data to Physiological Significance.Front Cell Dev Biol2020
31841063Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies.Autophagy2020
32044344Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy.J Mol Biol2020
31828313Homologous recombination repair intermediates promote efficient de novo telomere addition at DNA double-strand breaks.Nucleic Acids Res2020
33325825Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.Elife2020
30610712In Vitro Screening Platforms for Identifying Autophagy Modulators in Mammalian Cells.Methods Mol Biol2019
31555645Biomedical Implications of Autophagy in Macromolecule Storage Disorders.Front Cell Dev Biol2019
30949479Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases.Front Cell Dev Biol2019
30804224BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma.Genes Dev2019
30483501Selective Autophagy and Xenophagy in Infection and Disease.Front Cell Dev Biol2018
28792845Discovery of pan autophagy inhibitors through a high-throughput screen highlights macroautophagy as an evolutionarily conserved process across 3 eukaryotic kingdoms.Autophagy2017
29233882Dysregulation of autophagy as a common mechanism in lysosomal storage diseases.Essays Biochem2017
28694500Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle.Sci Rep2017
26799652Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy2016
27572704PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder.Sci Rep2016
27131361A role for human homologous recombination factors in suppressing microhomology-mediated end joining.Nucleic Acids Res2016
26778751Autophagy, lipophagy and lysosomal lipid storage disorders.Biochim Biophys Acta2016
26742086Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.Elife2016
26682798The spliceosome-associated protein Nrl1 suppresses homologous recombination-dependent R-loop formation in fission yeast.Nucleic Acids Res2016
24965527Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis.Amino Acids2015
26602815Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.Cancer Cell2015
26195741Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.Proc Natl Acad Sci U S A2015
24623809The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast.Nucleic Acids Res2014
25454632Direct lineage conversion of adult mouse liver cells and B lymphocytes to neural stem cells.Stem Cell Reports2014
25192464The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.Cell Stem Cell2014
24936472Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells.Stem Cell Reports2014
24909977A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice.Nat Commun2014
24879158Restarting stalled autophagy a potential therapeutic approach for the lipid storage disorder, Niemann-Pick type C1 disease.Autophagy2014
24931610SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability.Cell Rep2014
24518136Autophagy researchers: Fu-Cheng Lin, Dalibor Mijaljica, Sovan Sarkar, Teresa Zoladek.Autophagy2014
24553937N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury.J Neurosci2014
23792629Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling.Nat Biotechnol2013
24360959A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.Cell Rep2013
24290752Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease.Cell Rep2013
24050242Chemical screening platforms for autophagy drug discovery to identify therapeutic candidates for Huntington's disease and other neurodegenerative disorders.Drug Discov Today Technol2013
24059496Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.Biochem Soc Trans2013
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Collaborators

Peter J McHugh
MRC Weatherall Institute of Molecular Medicine, University of Oxford
Co-authored papers 6
Dhiraj Kumar
Johns Hopkins University School of Medicine
Co-authored papers 6
Rodrigo Andres Floto
University of Cambridge
Co-authored papers 5
Stuart L Schreiber
Broad Institute
Co-authored papers 3
Haoyi Wang
Chinese Academy of Sciences
Co-authored papers 3
Susmita Kaushik
Albert Einstein College of Medicine
Co-authored papers 3
Ramnik J Xavier
Broad Institute of MIT and Harvard
Co-authored papers 3
Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 3
Ioannis P Nezis
University of Warwick
Co-authored papers 3
Thomas J Begley
University at Albany
Co-authored papers 2
Malene Hansen
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Kun-Liang Guan
University of California San Diego
Co-authored papers 2
Colin R Goding
Ludwig Institute for Cancer Research, University of Oxford
Co-authored papers 2
Laura Santambrogio
Weill Cornell School of Medicine
Co-authored papers 2
Scott J Bultman
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Co-authored papers 2
Masashi Narita
Co-authored papers 2
Karin Przyklenk
Co-authored papers 2
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 2
Svetlana Dokudovskaya
CNRS UMR9018, Institut Gustave Roussy, Universite Paris-Saclay
Co-authored papers 2
Hirotaka Watada
Co-authored papers 2
Sara Cherry
University of Pennsylvania
Co-authored papers 2
Nancy L Glass
University of California Berkeley
Co-authored papers 2
Owen R Davies
Institute of Cell Biology, University of Edinburgh
Co-authored papers 2
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 2
David Sulzer
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 2
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 2
J. Wade Harper
Harvard Medical School
Co-authored papers 2
Nikolai V Gorbunov
Armed Forces Radiobiology Research Institute
Co-authored papers 2
Juan Fueyo
The University of Texas M.D. Anderson Cancer Center
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Release 1.2